2k20

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[[Image:2k20.jpg|left|200px]]
 
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==Solution structure of Par-3 PDZ3 in complex with PTEN peptide==
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The line below this paragraph, containing "STRUCTURE_2k20", creates the "Structure Box" on the page.
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<StructureSection load='2k20' size='340' side='right'caption='[[2k20]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k20]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K20 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k20 OCA], [https://pdbe.org/2k20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k20 RCSB], [https://www.ebi.ac.uk/pdbsum/2k20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k20 ProSAT]</span></td></tr>
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{{STRUCTURE_2k20| PDB=2k20 | SCENE= }}
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</table>
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== Function ==
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'''Solution structure of Par-3 PDZ3 in complex with PTEN peptide'''
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[https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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2K20 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K20 OCA].
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<jmolCheckbox>
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[[Category: Protein complex]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k20_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k20 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chan, L.]]
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[[Category: Chan L]]
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[[Category: Feng, W.]]
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[[Category: Feng W]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zhang, M.]]
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[[Category: Zhang M]]
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[[Category: Alternative splicing]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Cell junction]]
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[[Category: Cell polarity]]
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[[Category: Coiled coil]]
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[[Category: Membrane]]
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[[Category: Par-3]]
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[[Category: Pdz domain]]
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[[Category: Phosphoprotein]]
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[[Category: Pten]]
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[[Category: Scaffold protein]]
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[[Category: Signaling protein]]
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[[Category: Tight junction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 11 10:43:23 2008''
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Current revision

Solution structure of Par-3 PDZ3 in complex with PTEN peptide

PDB ID 2k20

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