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2k3h

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==Structural determinants for Ca2+ and PIP2 binding by the C2A domain of rabphilin-3A==
==Structural determinants for Ca2+ and PIP2 binding by the C2A domain of rabphilin-3A==
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<StructureSection load='2k3h' size='340' side='right' caption='[[2k3h]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2k3h' size='340' side='right'caption='[[2k3h]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2k3h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K3H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K3H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2k3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K3H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rph3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k3h OCA], [http://pdbe.org/2k3h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k3h RCSB], [http://www.ebi.ac.uk/pdbsum/2k3h PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k3h OCA], [https://pdbe.org/2k3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k3h RCSB], [https://www.ebi.ac.uk/pdbsum/2k3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k3h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RP3A_MOUSE RP3A_MOUSE]] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
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[https://www.uniprot.org/uniprot/RP3A_MOUSE RP3A_MOUSE] Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/2k3h_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k3/2k3h_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 2k3h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2k3h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Exophilin 3D structures|Exophilin 3D structures]]
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*[[Rabphilin|Rabphilin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Becker, S]]
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[[Category: Mus musculus]]
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[[Category: Coudevylle, N]]
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[[Category: Becker S]]
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[[Category: Leonov, A]]
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[[Category: Coudevylle N]]
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[[Category: Montaville, P]]
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[[Category: Leonov A]]
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[[Category: Zweckstetter, M]]
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[[Category: Montaville P]]
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[[Category: C2 domain]]
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[[Category: Zweckstetter M]]
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[[Category: Cell junction]]
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[[Category: Metal-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Pip2]]
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[[Category: Protein transport]]
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[[Category: Synapse]]
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[[Category: Tama mechanism]]
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[[Category: Transport]]
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[[Category: Zinc-finger]]
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Current revision

Structural determinants for Ca2+ and PIP2 binding by the C2A domain of rabphilin-3A

PDB ID 2k3h

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