This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2k4a
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway== | ==FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway== | ||
| - | <StructureSection load='2k4a' size='340' side='right'caption='[[2k4a | + | <StructureSection load='2k4a' size='340' side='right'caption='[[2k4a]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2k4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2k4a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K4A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K4A FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4a OCA], [https://pdbe.org/2k4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4a RCSB], [https://www.ebi.ac.uk/pdbsum/2k4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4a ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k4a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k4a OCA], [https://pdbe.org/2k4a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k4a RCSB], [https://www.ebi.ac.uk/pdbsum/2k4a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k4a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SYT1_HUMAN SYT1_HUMAN] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 23: | ||
*[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]] | *[[Fibroblast growth factor 3D structures|Fibroblast growth factor 3D structures]] | ||
*[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]] | *[[Synaptotagmin 3D structures|Synaptotagmin 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Mohan | + | [[Category: Mohan SK]] |
| - | [[Category: Yu | + | [[Category: Yu C]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
FGF-1-C2A binary complex structure: a key component in the fibroblast growthfactor non-classical pathway
| |||||||||||
