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2k5t

From Proteopedia

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[[Image:2k5t.png|left|200px]]
 
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{{STRUCTURE_2k5t| PDB=2k5t | SCENE= }}
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==Solution NMR Structure of Putative N-Acetyl Transferase YhhK from E. coli Bound to Coenzyme A: Northeast Structural Genomics Consortium Target ET106==
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<StructureSection load='2k5t' size='340' side='right'caption='[[2k5t]]' scene=''>
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===Solution NMR Structure of Putative N-Acetyl Transferase YhhK from E. coli Bound to Coenzyme A: Northeast Structural Genomics Consortium Target ET106===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2k5t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K5T FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr>
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[[2k5t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K5T OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k5t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k5t OCA], [https://pdbe.org/2k5t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k5t RCSB], [https://www.ebi.ac.uk/pdbsum/2k5t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k5t ProSAT], [https://www.topsan.org/Proteins/NESGC/2k5t TOPSAN]</span></td></tr>
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[[Category: Escherichia coli k-12]]
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</table>
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[[Category: Arrowsmith, C H.]]
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== Function ==
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[[Category: Cort, J R.]]
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[https://www.uniprot.org/uniprot/PANZ_ECOLI PANZ_ECOLI] Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion. Binding of CoA or a derivative to PanZ leads to interaction with PanD, which promotes the processing and activation of pro-PanD, and subsequent substrate-mediated inhibition of the active form of PanD (PubMed:23170229, PubMed:25910242). Inhibition of PanD activity is probably the primary metabolic role of PanZ, allowing negative feedback regulation of pantothenate biosynthesis by CoA (PubMed:25910242).<ref>PMID:23170229</ref> <ref>PMID:25910242</ref>
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[[Category: Kennedy, M A.]]
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== Evolutionary Conservation ==
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[[Category: Montelione, G T.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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Check<jmol>
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[[Category: Yee, A.]]
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<jmolCheckbox>
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[[Category: Bound ligand]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k5/2k5t_consurf.spt"</scriptWhenChecked>
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[[Category: Coa]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Coenzyme some]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: N-acetyl transferase]]
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</jmolCheckbox>
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[[Category: Nesg]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k5t ConSurf].
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[[Category: Northeast structural genomics consortium]]
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<div style="clear:both"></div>
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[[Category: Protein structure initiative]]
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== References ==
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[[Category: Psi-2]]
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<references/>
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[[Category: Structural genomic]]
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__TOC__
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[[Category: Transferase]]
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</StructureSection>
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[[Category: Unknown function]]
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Cort JR]]
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[[Category: Kennedy MA]]
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[[Category: Montelione GT]]
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[[Category: Yee A]]

Current revision

Solution NMR Structure of Putative N-Acetyl Transferase YhhK from E. coli Bound to Coenzyme A: Northeast Structural Genomics Consortium Target ET106

PDB ID 2k5t

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