2k6b

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{{Seed}}
 
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[[Image:2k6b.png|left|200px]]
 
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==Solution structure of 1-112 fragment of human programmed cell death 5 protein==
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The line below this paragraph, containing "STRUCTURE_2k6b", creates the "Structure Box" on the page.
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<StructureSection load='2k6b' size='340' side='right'caption='[[2k6b]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k6b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6B FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6b OCA], [https://pdbe.org/2k6b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6b RCSB], [https://www.ebi.ac.uk/pdbsum/2k6b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6b ProSAT]</span></td></tr>
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{{STRUCTURE_2k6b| PDB=2k6b | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDCD5_HUMAN PDCD5_HUMAN] May function in the process of apoptosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/2k6b_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k6b ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human programmed cell death 5 (PDCD5) is a translocatory protein playing an important role in the apoptotic process of cells. Although there are accumulated data about PDCD5 function, the correlation of the structure with the function of PDCD5 has not been investigated. Here, we report the studies of structure-function relationship of PDCD5 by multidimensional NMR methods and by FACScan flow cytometer and fluorescence microscope. The 3D structure of intact PDCD5 and the internal motions of PDCD5 have been determined. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal region and a flexible unstructured C-terminal region. The flow cytometry and internalization measurements of different PDCD5 fragments indicate that the charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. Combined analyses reveal a fact that the regions that seem to be most involved in the function also are more flexible in PDCD5.
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===Solution structure of 1-112 fragment of human programmed cell death 5 protein===
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Structure-function correlation of human programmed cell death 5 protein.,Yao H, Xu L, Feng Y, Liu D, Chen Y, Wang J Arch Biochem Biophys. 2009 Jun 15;486(2):141-9. Epub 2009 Apr 7. PMID:19358820<ref>PMID:19358820</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2k6b" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19358820}}, adds the Publication Abstract to the page
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*[[Cell death protein 3D structures|Cell death protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19358820 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19358820}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2K6B is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6B OCA].
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==Reference==
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<ref group="xtra">PMID:19358820</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Feng, Y.]]
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[[Category: Large Structures]]
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[[Category: Liu, D.]]
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[[Category: Feng Y]]
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[[Category: Wang, J.]]
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[[Category: Liu D]]
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[[Category: Yao, H.]]
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[[Category: Wang J]]
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[[Category: Apoptosis]]
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[[Category: Yao H]]
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[[Category: Pdcd5]]
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[[Category: Phosphoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 25 08:29:14 2009''
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Current revision

Solution structure of 1-112 fragment of human programmed cell death 5 protein

PDB ID 2k6b

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