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2kia

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Current revision (19:12, 29 May 2024) (edit) (undo)
 
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==Solution structure of Myosin VI C-terminal cargo-binding domain==
==Solution structure of Myosin VI C-terminal cargo-binding domain==
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<StructureSection load='2kia' size='340' side='right'caption='[[2kia]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kia' size='340' side='right'caption='[[2kia]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kia]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KIA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Myo6, Sv ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kia OCA], [https://pdbe.org/2kia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kia RCSB], [https://www.ebi.ac.uk/pdbsum/2kia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kia ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kia OCA], [https://pdbe.org/2kia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kia RCSB], [https://www.ebi.ac.uk/pdbsum/2kia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kia ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE]] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.
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[https://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE] Note=Defects in Myo6 are the cause of Snell's waltzer, a condition characterized by circling, head-tossing, deafness and hyperactivity.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
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[https://www.uniprot.org/uniprot/MYO6_MOUSE MYO6_MOUSE] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Feng, W]]
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[[Category: Feng W]]
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[[Category: Miyanoiri, Y]]
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[[Category: Miyanoiri Y]]
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[[Category: Wei, Z]]
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[[Category: Wei Z]]
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[[Category: Yu, C]]
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[[Category: Yu C]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Actin-binding]]
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[[Category: Atp-binding]]
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[[Category: Calmodulin-binding]]
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[[Category: Cargo-binding domain]]
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[[Category: Cell projection]]
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[[Category: Coated pit]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasm]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Deafness]]
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[[Category: Disease mutation]]
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[[Category: Endocytosis]]
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[[Category: Golgi apparatus]]
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[[Category: Hearing]]
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[[Category: Membrane]]
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[[Category: Molecular motor]]
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[[Category: Motor protein]]
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[[Category: Myosin]]
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[[Category: Myosin vi]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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Current revision

Solution structure of Myosin VI C-terminal cargo-binding domain

PDB ID 2kia

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