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2kki

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[[Image:2kki.png|left|200px]]
 
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{{STRUCTURE_2kki| PDB=2kki | SCENE= }}
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==Solution structure of human Interleukin 1a==
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<StructureSection load='2kki' size='340' side='right'caption='[[2kki]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2kki]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kki OCA], [https://pdbe.org/2kki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kki RCSB], [https://www.ebi.ac.uk/pdbsum/2kki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kki ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IL1A_HUMAN IL1A_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/2kki_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kki ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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As part of our NMR structure determination of the human Interleukin-1alpha, we report nearly complete NMR chemical shift assignments for the (1)H, (13)C and (15)N nuclei.
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===Solution structure of human Interleukin 1a===
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1H, 13C and 15N backbone and side chain resonance assignments of human interleukin 1alpha.,Chang HK, Mohan SK, Chin Y Biomol NMR Assign. 2010 Apr;4(1):59-60. Epub 2010 Jan 28. PMID:20108067<ref>PMID:20108067</ref>
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{{ABSTRACT_PUBMED_20108067}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 2kki" style="background-color:#fffaf0;"></div>
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[[2kki]] is a 1 chain structure of [[Interleukin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKI OCA].
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==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020108067</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chang, H K.]]
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[[Category: Large Structures]]
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[[Category: Mohan, S K.]]
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[[Category: Chang H-K]]
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[[Category: Yu, C.]]
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[[Category: Mohan SK]]
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[[Category: Cytokine]]
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[[Category: Yu C]]
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[[Category: Glycoprotein]]
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[[Category: Inflammatory response]]
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[[Category: Lipoprotein]]
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[[Category: Mitogen]]
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[[Category: Myristate]]
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[[Category: Protein]]
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[[Category: Pyrogen]]
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[[Category: Secreted]]
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Current revision

Solution structure of human Interleukin 1a

PDB ID 2kki

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