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2kki

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==Solution structure of human Interleukin 1a==
==Solution structure of human Interleukin 1a==
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<StructureSection load='2kki' size='340' side='right' caption='[[2kki]], [[NMR_Ensembles_of_Models | 14 NMR models]]' scene=''>
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<StructureSection load='2kki' size='340' side='right'caption='[[2kki]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kki]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KKI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kki]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KKI FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IL1A, IL1F1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kki OCA], [http://pdbe.org/2kki PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kki RCSB], [http://www.ebi.ac.uk/pdbsum/2kki PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2kki ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kki OCA], [https://pdbe.org/2kki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kki RCSB], [https://www.ebi.ac.uk/pdbsum/2kki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kki ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IL1A_HUMAN IL1A_HUMAN]] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
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[https://www.uniprot.org/uniprot/IL1A_HUMAN IL1A_HUMAN] Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Interleukin|Interleukin]]
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*[[Interleukin 3D structures|Interleukin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Chang, H K]]
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[[Category: Large Structures]]
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[[Category: Mohan, S K]]
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[[Category: Chang H-K]]
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[[Category: Yu, C]]
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[[Category: Mohan SK]]
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[[Category: Cytokine]]
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[[Category: Yu C]]
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[[Category: Glycoprotein]]
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[[Category: Inflammatory response]]
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[[Category: Lipoprotein]]
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[[Category: Mitogen]]
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[[Category: Myristate]]
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[[Category: Polymorphism]]
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[[Category: Protein]]
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[[Category: Pyrogen]]
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[[Category: Secreted]]
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Current revision

Solution structure of human Interleukin 1a

PDB ID 2kki

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