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2klo

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==Structure of the Cdt1 C-terminal domain==
==Structure of the Cdt1 C-terminal domain==
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<StructureSection load='2klo' size='340' side='right' caption='[[2klo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2klo' size='340' side='right'caption='[[2klo]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2klo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KLO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2klo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KLO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KLO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3a4c|3a4c]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cdt1, Ris2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2klo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klo OCA], [https://pdbe.org/2klo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2klo RCSB], [https://www.ebi.ac.uk/pdbsum/2klo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2klo ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2klo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2klo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2klo RCSB], [http://www.ebi.ac.uk/pdbsum/2klo PDBsum]</span></td></tr>
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</table>
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<table>
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== Function ==
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[https://www.uniprot.org/uniprot/CDT1_MOUSE CDT1_MOUSE] Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.<ref>PMID:11850834</ref> <ref>PMID:12192004</ref> <ref>PMID:14993212</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klo_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kl/2klo_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2klo ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2klo" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Bae, W J.]]
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[[Category: Bae WJ]]
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[[Category: Cheong, C.]]
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[[Category: Cheong C]]
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[[Category: Cheong, H K.]]
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[[Category: Cheong H-K]]
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[[Category: Cho, Y.]]
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[[Category: Cho Y]]
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[[Category: Guntert, P.]]
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[[Category: Guntert P]]
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[[Category: Hwang, E.]]
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[[Category: Hwang E]]
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[[Category: Jeon, Y H.]]
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[[Category: Jeon YH]]
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[[Category: Karplus, P A.]]
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[[Category: Karplus PA]]
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[[Category: Khayrutdinov, B I.]]
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[[Category: Khayrutdinov BI]]
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[[Category: Kim, J J.]]
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[[Category: Kim JJ]]
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[[Category: Ryu, K S.]]
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[[Category: Ryu K-S]]
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[[Category: Tada, S.]]
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[[Category: Tada S]]
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[[Category: Tsuyama, T.]]
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[[Category: Tsuyama T]]
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[[Category: Yun, Y M.]]
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[[Category: Yun YM]]
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[[Category: Cell cycle]]
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[[Category: Dna replication]]
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[[Category: Dna-binding]]
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[[Category: Mcm binding]]
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[[Category: Mouse cdt1]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Proto-oncogene]]
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[[Category: Replication licensing factor]]
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[[Category: Winged helix fold]]
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Current revision

Structure of the Cdt1 C-terminal domain

PDB ID 2klo

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