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2kma

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==NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain==
==NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain==
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<StructureSection load='2kma' size='340' side='right' caption='[[2kma]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2kma' size='340' side='right'caption='[[2kma]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2kma]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2KMA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2kma]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RP23-195K8.11-001, TLN, Tln1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kma OCA], [http://pdbe.org/2kma PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2kma RCSB], [http://www.ebi.ac.uk/pdbsum/2kma PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kma FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kma OCA], [https://pdbe.org/2kma PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kma RCSB], [https://www.ebi.ac.uk/pdbsum/2kma PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kma ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
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[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kma_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2kma_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kma ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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==See Also==
==See Also==
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*[[Talin|Talin]]
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*[[Talin 3D structures|Talin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Barsukov, I L]]
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[[Category: Mus musculus]]
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[[Category: Bate, N]]
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[[Category: Barsukov IL]]
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[[Category: Critchley, D R]]
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[[Category: Bate N]]
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[[Category: Elliott, P R]]
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[[Category: Critchley DR]]
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[[Category: Goult, B T]]
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[[Category: Elliott PR]]
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[[Category: Roberts, G C]]
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[[Category: Goult BT]]
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[[Category: Adhesion]]
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[[Category: Roberts GC]]
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[[Category: Cytoskeleton]]
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[[Category: F0]]
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[[Category: F1]]
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[[Category: Ferm]]
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[[Category: Membrane]]
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[[Category: N-terminal]]
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[[Category: Structural protein]]
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[[Category: Talin]]
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Current revision

NMR structure of the F0F1 double domain (residues 1-202) of the talin ferm domain

PDB ID 2kma

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