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2os6
From Proteopedia
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| - | [[Image:2os6.jpg|left|200px]]<br /><applet load="2os6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2os6" /> | ||
| - | '''Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1'''<br /> | ||
| - | == | + | ==Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1== |
| - | + | <StructureSection load='2os6' size='340' side='right'caption='[[2os6]]' scene=''> | |
| - | [ | + | == Structural highlights == |
| - | [[ | + | <table><tr><td colspan='2'>[[2os6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OS6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OS6 FirstGlance]. <br> |
| - | [[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | [ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2os6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2os6 OCA], [https://pdbe.org/2os6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2os6 RCSB], [https://www.ebi.ac.uk/pdbsum/2os6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2os6 ProSAT]</span></td></tr> |
| - | [ | + | </table> |
| - | [ | + | == Disease == |
| - | [[ | + | [https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN] Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL. |
| - | [ | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ARHGC_HUMAN ARHGC_HUMAN] May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.<ref>PMID:11094164</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/os/2os6_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2os6 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| - | + | ==See Also== | |
| + | *[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Huang H]] | ||
| + | [[Category: Liu J]] | ||
| + | [[Category: Yang Y]] | ||
Current revision
Solution structure of LARG PDZ domain in complex with C-terminal octa-peptide of Plexin B1
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Categories: Homo sapiens | Large Structures | Huang H | Liu J | Yang Y
