1sj9

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[[Image:1sj9.gif|left|200px]]
[[Image:1sj9.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1sj9 |SIZE=350|CAPTION= <scene name='initialview01'>1sj9</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_1sj9", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Uridine_phosphorylase Uridine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.3 2.4.2.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= udp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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-->
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|DOMAIN=
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{{STRUCTURE_1sj9| PDB=1sj9 | SCENE= }}
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|RELATEDENTRY=[[1ryz|1RYZ]], [[1k3f|1K3F]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sj9 OCA], [http://www.ebi.ac.uk/pdbsum/1sj9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sj9 RCSB]</span>
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}}
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'''Crystal structure of the uridine phosphorylase from Salmonella typhimurium at 2.5A resolution'''
'''Crystal structure of the uridine phosphorylase from Salmonella typhimurium at 2.5A resolution'''
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[[Category: Morgunova, E.]]
[[Category: Morgunova, E.]]
[[Category: Nikonov, S.]]
[[Category: Nikonov, S.]]
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[[Category: nucleoside phosphorylase]]
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[[Category: Nucleoside phosphorylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:46:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:42:46 2008''
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Revision as of 05:46, 3 May 2008

Image:1sj9.gif

Template:STRUCTURE 1sj9

Crystal structure of the uridine phosphorylase from Salmonella typhimurium at 2.5A resolution


Overview

Uridine phosphorylase (UPh) catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose 1-phosphate and uracil in the pyrimidine-salvage pathway. The crystal structure of the Salmonella typhimurium uridine phosphorylase (StUPh) has been determined at 2.5 A resolution and refined to an R factor of 22.1% and an Rfree of 27.9%. The hexameric StUPh displays 32 point-group symmetry and utilizes both twofold and threefold non-crystallographic axes. A phosphate is bound at the active site and forms hydrogen bonds to Arg91, Arg30, Thr94 and Gly26 of one monomer and Arg48 of an adjacent monomer. The hexameric StUPh model reveals a close structural relationship to Escherichia coli uridine phosphorylase (EcUPh).

About this Structure

1SJ9 is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state., Dontsova MV, Gabdoulkhakov AG, Molchan OK, Lashkov AA, Garber MB, Mironov AS, Zhukhlistova NE, Morgunova EY, Voelter W, Betzel C, Zhang Y, Ealick SE, Mikhailov AM, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt, 4):337-40. Epub 2005 Mar 24. PMID:16511035 Page seeded by OCA on Sat May 3 08:46:16 2008

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