2yqg

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[[Image:2yqg.gif|left|200px]]
 
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{{Structure
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==Solution structure of the first cadherin domain from human Desmoglein-2==
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|PDB= 2yqg |SIZE=350|CAPTION= <scene name='initialview01'>2yqg</scene>
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<StructureSection load='2yqg' size='340' side='right'caption='[[2yqg]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2yqg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQG FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= DSG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqg OCA], [https://pdbe.org/2yqg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqg RCSB], [https://www.ebi.ac.uk/pdbsum/2yqg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqg ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqg TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Disease ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yqg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqg OCA], [http://www.ebi.ac.uk/pdbsum/2yqg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2yqg RCSB]</span>
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[https://www.uniprot.org/uniprot/DSG2_HUMAN DSG2_HUMAN] Defects in DSG2 are the cause of familial arrhythmogenic right ventricular dysplasia type 10 (ARVD10) [MIM:[https://omim.org/entry/610193 610193]; also known as arrhythmogenic right ventricular cardiomyopathy 10 (ARVC10). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.<ref>PMID:16773573</ref> <ref>PMID:20031617</ref> <ref>PMID:19863551</ref> <ref>PMID:21062920</ref> Genetic variations in DSG2 are the cause of susceptibility to cardiomyopathy dilated type 1BB (CMD1BB) [MIM:[https://omim.org/entry/612877 612877]. A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:18678517</ref>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/DSG2_HUMAN DSG2_HUMAN] Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/2yqg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yqg ConSurf].
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<div style="clear:both"></div>
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'''Solution structure of the first cadherin domain from human Desmoglein-2'''
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==See Also==
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*[[Cadherin 3D structures|Cadherin 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Arrhythmogenic right ventricular dysplasia, familial, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=125671 125671]]
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__TOC__
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</StructureSection>
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==About this Structure==
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2YQG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQG OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hayashi, F.]]
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[[Category: Hayashi F]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sano R]]
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[[Category: Sano, R.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: Yoshida M]]
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[[Category: Yoshida, M.]]
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[[Category: cadherin]]
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[[Category: cell adhesion]]
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[[Category: hdgc]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:14:26 2008''
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Current revision

Solution structure of the first cadherin domain from human Desmoglein-2

PDB ID 2yqg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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