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2yqk
From Proteopedia
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| - | [[Image:2yqk.gif|left|200px]]<br /><applet load="2yqk" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2yqk" /> | ||
| - | '''Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats'''<br /> | ||
| - | == | + | ==Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats== |
| - | + | <StructureSection load='2yqk' size='340' side='right'caption='[[2yqk]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2yqk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YQK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yqk OCA], [https://pdbe.org/2yqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yqk RCSB], [https://www.ebi.ac.uk/pdbsum/2yqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yqk ProSAT], [https://www.topsan.org/Proteins/RSGI/2yqk TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN] Note=A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24). | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RERE_HUMAN RERE_HUMAN] Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.<ref>PMID:11331249</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yq/2yqk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yqk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: He | + | [[Category: He F]] |
| - | [[Category: Inoue | + | [[Category: Inoue M]] |
| - | [[Category: Kadirvel | + | [[Category: Kadirvel S]] |
| - | [[Category: Kigawa | + | [[Category: Kigawa T]] |
| - | [[Category: Muto | + | [[Category: Muto Y]] |
| - | + | [[Category: Shirouzu M]] | |
| - | [[Category: Shirouzu | + | [[Category: Tarada T]] |
| - | [[Category: Tarada | + | [[Category: Yokoyama S]] |
| - | [[Category: Yokoyama | + | |
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Current revision
Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats
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Categories: Homo sapiens | Large Structures | He F | Inoue M | Kadirvel S | Kigawa T | Muto Y | Shirouzu M | Tarada T | Yokoyama S
