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4kyk
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4kyk is ON HOLD Authors: Zhai, J., Yuan, M., Zhang, L., Chen, Y., Zhang, H., Chen, S., Zhao, Y. Description: Crystal structure of mouse glyoxalase ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of mouse glyoxalase I complexed with indomethacin== | |
| + | <StructureSection load='4kyk' size='340' side='right'caption='[[4kyk]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4kyk]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KYK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IMN:INDOMETHACIN'>IMN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kyk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kyk OCA], [https://pdbe.org/4kyk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kyk RCSB], [https://www.ebi.ac.uk/pdbsum/4kyk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kyk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Old drugs new tricks: Zopolrestat, an aldose reductase inhibitor developed by Pfizer for the treatment of diabetic complications, is a potent competition inhibitor of human glyoxalase I (GLOI) in vitro. Crystal structures of GLOI in complex with zopolrestat and indomethacin, a nonsteroidal anti-inflammatory drug and moderate inhibitor of GLOI, provide a structural basis for the development of novel GLOI inhibitors with excellent pharmacokinetics profiles. | ||
| - | + | Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis.,Zhai J, Zhang H, Zhang L, Zhao Y, Chen S, Chen Y, Peng X, Li Q, Yuan M, Hu X ChemMedChem. 2013 Jul 15. doi: 10.1002/cmdc.201300243. PMID:23857942<ref>PMID:23857942</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| + | </div> | ||
| + | <div class="pdbe-citations 4kyk" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glyoxalase 3D structures|Glyoxalase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Chen S]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Yuan M]] | ||
| + | [[Category: Zhai J]] | ||
| + | [[Category: Zhang H]] | ||
| + | [[Category: Zhang L]] | ||
| + | [[Category: Zhao Y]] | ||
Current revision
Crystal structure of mouse glyoxalase I complexed with indomethacin
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Categories: Large Structures | Mus musculus | Chen S | Chen Y | Yuan M | Zhai J | Zhang H | Zhang L | Zhao Y
