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7lj9
From Proteopedia
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<StructureSection load='7lj9' size='340' side='right'caption='[[7lj9]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='7lj9' size='340' side='right'caption='[[7lj9]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'> | + | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LJ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LJ9 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | |
| - | <tr id=' | + | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj9 OCA], [https://pdbe.org/7lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lj9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lj9 OCA], [https://pdbe.org/7lj9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lj9 RCSB], [https://www.ebi.ac.uk/pdbsum/7lj9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lj9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN]] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: ATP citrate synthase]] | ||
| - | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Marmorstein | + | [[Category: Marmorstein R]] |
| - | [[Category: Wei | + | [[Category: Wei X]] |
| - | + | ||
Current revision
Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate
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