7mk2

<table><tr><td colspan='2'>[[7mk2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MK2 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/NPR1_ARATH NPR1_ARATH]] May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, a biphasic change in cellular reduction potential occurs, resulting in reduction of the cytoplasmic oligomeric form to a monomeric form that accumulates in the nucleus and activates gene expression. Phosphorylated form is target of proteasome degradation.<ref>PMID:11607555</ref> <ref>PMID:12615947</ref> <ref>PMID:12837250</ref> <ref>PMID:12897257</ref> <ref>PMID:12953119</ref> <ref>PMID:9002272</ref> <ref>PMID:9019406</ref>

== References ==

<references/>

[[Category: Bartesaghi, A]]

[[Category: Borgnia, M]]

[[Category: Dillard, L]]

[[Category: Kumar, S]]

[[Category: Zhou, P]]

[[Category: Zhou, Y]]

[[Category: Sar]]