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8iwl
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8iwl is ON HOLD Authors: Lee, G.H., Park, H.H. Description: A.baumannii Uncharacterized sugar kinase ydjH Category: Unreleased Structures [[Cat...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==A.baumannii Uncharacterized sugar kinase ydjH== | |
| + | <StructureSection load='8iwl' size='340' side='right'caption='[[8iwl]], [[Resolution|resolution]] 3.04Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8iwl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IWL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.04Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iwl OCA], [https://pdbe.org/8iwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iwl RCSB], [https://www.ebi.ac.uk/pdbsum/8iwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iwl ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Bacterial sugar kinase is a central enzyme for proper sugar degradation in bacteria, essential for survival and growth. Therefore, this enzyme family is a primary target for antibacterial drug development, with YdjH most preferring to phosphorylate higher-order monosaccharides with a carboxylate terminus. Sugar kinases express diverse specificity and functions, making specificity determination of this family a prominent issue. This study examines the YdjH crystal structure from Acinetobacter baumannii (abYdjH), which has an exceptionally high antibiotic resistance and is considered a superbug. Our structural and biochemical study revealed that abYdjH has a widely open lid domain and is a solution dimer. In addition, the putative active site of abYdjH was determined based on structural analysis, sequence comparison, and in silico docking. Finally, we proposed the active site-forming residues that determine various sugar specificities from abYdjH. This study contributes towards a deeper understanding of the phosphorylation process and bacterial sugar metabolism of YdjH family to design the next-generation antibiotics for targeting A. baumannii. | ||
| - | + | Structure of YdjH from Acinetobacter baumannii revealed an active site of YdjH family sugar kinase.,Lee GH, Kim JH, Ha HJ, Park HH Biochem Biophys Res Commun. 2023 Jul 5;664:27-34. doi: , 10.1016/j.bbrc.2023.04.073. Epub 2023 Apr 22. PMID:37130458<ref>PMID:37130458</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8iwl" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acinetobacter baumannii]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lee GH]] | ||
| + | [[Category: Park HH]] | ||
Current revision
A.baumannii Uncharacterized sugar kinase ydjH
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