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Beta-lactamase 3D structures

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(New page: == 3D Structures of Beta-lactamase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *'''β-lactamase class A''' ...)
Current revision (09:10, 30 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 7: Line 7:
**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
-
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]] - EcBlac A Tem-1<br />
+
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]], [[7u6q]] - EcBlac A Tem-1<br />
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br />
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br />
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
Line 14: Line 14:
**[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
**[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
 +
**[[7qor]] – EcBlac Tem-171 <br />
**[[5chu]], [[5cgs]] – EcBlac FOX-4<br />
**[[5chu]], [[5cgs]] – EcBlac FOX-4<br />
**[[5cgw]] – EcBlac FOX-4 (mutant)<br />
**[[5cgw]] – EcBlac FOX-4 (mutant)<br />
**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br />
**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
**[[4id4]] – EcBlac/PaBlac Tem<br />
-
**[[3o3v]] – EcBlac peptidase domain<br />
 
**[[1o7e]], [[1n4o]], [[5ne2]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
**[[1o7e]], [[1n4o]], [[5ne2]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br />
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br />
Line 29: Line 29:
**[[3ni9]] - PaBlac A Ges-2<br />
**[[3ni9]] - PaBlac A Ges-2<br />
**[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
**[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
-
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
+
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - ''Staphylococcus aureus''<br />
**[[3blm]] – SaBlac A<br />
**[[3blm]] – SaBlac A<br />
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]], [[5zfl]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
Line 37: Line 37:
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
-
**[[4c6y]], [[4c75]], [[5fqm]] – Blac – synthetic<br />
+
**[[4c6y]], [[4c75]], [[5fqm]], [[6tww]], [[6txd]], [[6ty6]], [[6yrs]] – Blac – synthetic<br />
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
 +
**[[6afm]], [[6afo]] - BtBlac A (mutant)<br />
**[[4yfm]] – Blac – ''Mycobacterium abscessus''<br />
**[[4yfm]] – Blac – ''Mycobacterium abscessus''<br />
**[[6ni1]] – BsBlac A – ''Bacillus subtilis''<br />
**[[6ni1]] – BsBlac A – ''Bacillus subtilis''<br />
**[[6niq]] – Blac A – ''Rhodopseudomonas palustris''<br />
**[[6niq]] – Blac A – ''Rhodopseudomonas palustris''<br />
**[[6nj1]] – Blac A – ''Clostridium kluyveri''<br />
**[[6nj1]] – Blac A – ''Clostridium kluyveri''<br />
-
**[[6b6a]], [[6b6b]], [[6b69]], [[6b68]], [[6b5x]] – MtBlac – ''Mycobacterium tuberculosis''<br />
+
**[[6b6a]], [[6b6b]], [[6b69]], [[6b68]], [[6b5x]], [[6n14]] – MtBlac – ''Mycobacterium tuberculosis''<br />
 +
**[[6v6n]] - Blac A (mutant) – ''Agrobacterium tumefaciens'' <br />
 +
**[[6w34]] – BcBlac A (mutant) - ''Bacillus cereus''<br />
 +
**[[6wip]] – Blac A – ''Micromonospora aurantiaca''<br />
 +
**[[6l3s]] – MmBlac Imp-27 – ''Morganella morganii''<br />
*β-lactamase class A binary complex
*β-lactamase class A binary complex
Line 52: Line 57:
**[[5fa7]] - EcBlac A + inhibitor<br />
**[[5fa7]] - EcBlac A + inhibitor<br />
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
 +
**[[8de0]] - EcBlac A Tem-1 + drug<br />
 +
**[[8de1]], [[8de2]] - EcBlac A Tem-1 (mutant) + drug<br />
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
Line 57: Line 64:
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]], [[5ee8]], [[4zam]] - KpBlac A Shv-1 + inhibitor<br />
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]], [[5ee8]], [[4zam]] - KpBlac A Shv-1 + inhibitor<br />
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
-
**[[5t66]] - KpBlac A + boronic acid inhibitor<br />
+
**[[5t66]], [[5zyb]] - KpBlac A + boronic acid inhibitor<br />
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br />
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br />
Line 63: Line 70:
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
-
**[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
+
**[[3nia]] - PaBlac A Ges-2 + inhibitor - ''Pseudomonas aeruginosa'' <br />
-
**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''<br />
+
**[[6q35]] - PaBlac A Ges-5 + boronic acid inhibitor <br />
 +
**[[3p98]] – MmBlac Tem-72 + citrate <br />
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br />
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br />
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br />
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br />
 +
**[[6afn]], [[6afp]] - BtBlac A (mutant) + boronic acid inhibitor <br />
**[[5ne1]] - StmBlac A + boronic acid inhibitor <br />
**[[5ne1]] - StmBlac A + boronic acid inhibitor <br />
 +
**[[6qw7]], [[6qw8]], [[7bj8]] - StmBlac A + inhibitor <br />
 +
**[[6w2z]] - BsBlac A + inhibitor <br />
 +
**[[6w33]] – BcBlac A (mutant) + inhibitor <br />
*β-lactamase class A binary complex with antibiotics
*β-lactamase class A binary complex with antibiotics
 +
**[[7qlp]], [[7qnk]] – EcBlac Tem-171 + antibiotic<br />
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
**[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br />
**[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br />
Line 86: Line 99:
*Extended-spectrum β-lactamase class A
*Extended-spectrum β-lactamase class A
-
**[[3ni9]] - PaESBL A GES-2<br />
+
**[[3ni9]] - PaESBL A Ges-2<br />
-
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
+
**[[4gnu]], [[4h8r]] - PaESBL A Ges-5<br />
-
**[[5f83]], [[5f82]] - PaESBL A GES-5 (mutant)<br />
+
**[[5f83]], [[5f82]] - PaESBL A Ges-5 (mutant)<br />
-
**[[3v3s]] – PaESBL GES-18<br />
+
**[[3v3s]] – PaESBL Ges-18<br />
-
**[[1e25]] – PaESBL PER-1 (mutant)<br />
+
**[[1e25]] – PaESBL Per-1 (mutant)<br />
**[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br />
**[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br />
**[[4wz5]] – PaESBL Oxa-10 <br />
**[[4wz5]] – PaESBL Oxa-10 <br />
**[[5mmy]], [[5mnu]] – PaESBL Oxa-10 (mutant)<br />
**[[5mmy]], [[5mnu]] – PaESBL Oxa-10 (mutant)<br />
**[[4yin]] – PaESBL Oxa-145 <br />
**[[4yin]] – PaESBL Oxa-145 <br />
-
**[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br />
+
**[[4d2o]], [[6dgu]] - CfESBL PER-2 – ''Citrobacter freundii''<br />
**[[5kzh]] - AbESBL A - ''Acinetobacter baumannii''<br />
**[[5kzh]] - AbESBL A - ''Acinetobacter baumannii''<br />
-
**[[3v3r]] - AbESBL A GES-11<br />
+
**[[3v3r]] - AbESBL A Ges-11<br />
-
**[[3tsg]] – AbESBL GES-14<br />
+
**[[3tsg]] – AbESBL Ges-14<br />
**[[4oqi]], [[4op8]], [[4op5]] - EcESBL Tem-1 (mutant)<br />
**[[4oqi]], [[4op8]], [[4op5]] - EcESBL Tem-1 (mutant)<br />
**[[4opy]] - EcESBL Tem-63 (mutant)<br />
**[[4opy]] - EcESBL Tem-63 (mutant)<br />
Line 104: Line 117:
**[[1ylj]], [[2p74]] – EcESBL Ctx-M-9<br />
**[[1ylj]], [[2p74]] – EcESBL Ctx-M-9<br />
**[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br />
**[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br />
-
**[[4ua6]] – EcESBL Ctx-M-14 <br />
+
**[[4ua6]], [[6d7h]] – EcESBL Ctx-M-14 <br />
-
**[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]] - EcBlac A Ctx-M-14 (mutant)<br />
+
**[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]], [[6d7i]], [[6v5e]], [[6v6g]], [[6v6p]], [[7k2x]] - EcBlac A Ctx-M-14 (mutant)<br />
-
**[[4hbt]] – EcESBL Ctx-M-15<br />
+
**[[4hbt]], [[7u57]] – EcESBL Ctx-M-15<br />
**[[1ylw]] - EcESBL Ctx-M-16<br />
**[[1ylw]] - EcESBL Ctx-M-16<br />
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br />
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br />
**[[5zb7]] – EcESBL Ctx-M-64<br />
**[[5zb7]] – EcESBL Ctx-M-64<br />
 +
**[[6j25]] - EcESBL Ctx-M-64 (mutant)<br />
**[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br />
**[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br />
**[[6c78]], [[6c79]], [[6c7a]] - EcESBLToho-1 <br />
**[[6c78]], [[6c79]], [[6c7a]] - EcESBLToho-1 <br />
-
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcESBLToho-1 (mutant) <br />
+
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]], [[6u58]] - EcESBLToho-1 (mutant) <br />
**[[2xqz]], [[2wyx]] - EcESBL Toho-1 (mutant) – Neutron<br />
**[[2xqz]], [[2wyx]] - EcESBL Toho-1 (mutant) – Neutron<br />
 +
**[[6nvt]] – EcESBL Tla-1 <br />
 +
**[[6pq9]] – EcESBL Tla-1 (mutant)<br />
**[[3zny]] - KpBlac A Ctx-M-12A (mutant) <br />
**[[3zny]] - KpBlac A Ctx-M-12A (mutant) <br />
**[[4pm8]] - KpBlac A Ctx-M-14 <br />
**[[4pm8]] - KpBlac A Ctx-M-14 <br />
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br />
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br />
-
**[[2qpn]] – KpESBL A GES-1<br />
+
**[[7bh3]], [[7bh4]], [[7bh5]], [[7bh6]], [[7bh7]] - KpBlac A Ctx-M-15 <br />
-
**[[5gs8]] – SmESBL TLA-3 <br />
+
**[[7qqc]], [[7r3q]], [[7r3r]] - KpBlac A Ctx-M-15 (mutant)<br />
 +
**[[2qpn]] – KpESBL A Ges-1<br />
 +
**[[6ts9]] - PaESBL A Ges-5<br />
 +
**[[5gs8]] – SmESBL Tla-3 <br />
**[[6bn3]] – SeESBL Ctx-M-151 – ''Salmonela enterica''<br />
**[[6bn3]] – SeESBL Ctx-M-151 – ''Salmonela enterica''<br />
Line 127: Line 146:
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br />
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br />
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br />
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br />
-
**[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br />
+
**[[4uaa]], [[4ua7]], [[6md8]], [[6mia]], [[6mz1]], [[6mz2]], [[6ooe]], [[6oof]], [[6ooj]], [[6ook]], [[7s0v]] – EcESBL Ctx-M-14 + inhibitor<br />
 +
**[[6bt6]], [[6v7h]], [[6v7t]], [[6v83]], [[6v8v]] – EcESBL Ctx-M-14 (mutant) + inhibitor<br />
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br />
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br />
-
**[[5vle]], [[5top]], [[5toy]] - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor<br />
+
**[[5vle]], [[5top]], [[5toy]], [[6vnu]] - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor<br />
 +
**[[6unb]] – EcESBL Ctx-M-14 + antibiotic<br />
 +
**[[7k2w]], [[7k2y]] – EcESBL Ctx-M-14 (mutant) + antibiotic<br />
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
-
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
+
**[[4hbu]], [[6sp6]], [[7u49]] – EcESBL Ctx-M-15 + inhibitor<br />
-
**[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br />
+
**[[4xuz]], [[7ti0]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br />
 +
**[[7u4b]] – EcESBL Ctx-M-15 + antibiotic<br />
**[[6bu3]] – EcESBL Ctx-M-27 + inhibitor<br />
**[[6bu3]] – EcESBL Ctx-M-27 + inhibitor<br />
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br />
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br />
 +
**[[6ity]], [[6j2o]] – EcESBL Ctx-M-64 + inhibitor<br />
 +
**[[6j2b]], [[6j2k]] – EcESBL Ctx-M-64 (mutant) + inhibitor<br />
**[[5g18]] - EcESBL Ctx-M-97 + substrate<br />
**[[5g18]] - EcESBL Ctx-M-97 + substrate<br />
**[[4oqh]] - EcESBL Tem-63 (mutant) + boronic acid inhibitor<br />
**[[4oqh]] - EcESBL Tem-63 (mutant) + boronic acid inhibitor<br />
**[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br />
**[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br />
**[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br />
**[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br />
-
**[[5x5g]] – SmESBL TLA-3 + inhibitor<br />
+
**[[6nvu]], [[6pq8]] – EcESBL Tla-1 + inhibitor<br />
 +
**[[5x5g]] – SmESBL Tla-3 + inhibitor<br />
**[[6bpf]] – SeESBL Ctx-M-151 + inhibitor <br />
**[[6bpf]] – SeESBL Ctx-M-151 + inhibitor <br />
 +
**[[6d3g]] – CfESBL Per-2 + inhibitor <br />
 +
**[[7bds]] – KpESBL Ctx-M-15 + drug <br />
 +
**[[7bdr]], [[7qq5]] – KpESBL Ctx-M-15 (mutant) + drug <br />
*Extended-spectrum β-lactamase class A binary complex with antibiotics
*Extended-spectrum β-lactamase class A binary complex with antibiotics
-
**[[4qu3]] - PaESBL A GES-2 + antibiotic<br />
+
**[[4qu3]] - PaESBL A Ges-2 + antibiotic<br />
**[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br />
**[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br />
**[[1ymx]] - EcESBL Ctx-M-9 + antibiotic<br />
**[[1ymx]] - EcESBL Ctx-M-9 + antibiotic<br />
**[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br />
**[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br />
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]], [[6cyu]], [[6cyq]]. [[6bt6]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]], [[6cyu]], [[6cyq]]. [[6bt6]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
-
**[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br />
+
**[[4pm9]], [[7q11]] - KpBlac A Ctx-M-14 + antibiotic<br />
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br />
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br />
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br />
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br />
-
**[[5gwa]] – SmESBL TLA-3 + antibiotic<br />
+
**[[5gwa]], [[7o0o]] – SmESBL Tla-3 + antibiotic<br />
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
Line 165: Line 194:
**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''
**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''
-
*'''β-lactamase class B (Zn containing) or metallo-β-lactamase'''
+
*'''β-lactamase class B (Zn containing) or metallo-β-lactamase or NDM'''
-
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]], [[5fqa]] – BcBlac B - ''Bacillus cereus''<br />
+
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]], [[5fqa]], [[6dja]] – BcBlac B<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[2m5c]] - BcBlac B – NMR<br />
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
Line 176: Line 205:
**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br />
**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br />
**[[1l9y]] - FgBlac B (mutant) <br />
**[[1l9y]] - FgBlac B (mutant) <br />
-
**[[5n5g]] - PaBlac B Vim-1 - ''Pseudomonas aeruginosa'' <br />
+
**[[5n5g]] - PaBlac B Vim-1<br />
-
**[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]], [[5yd7]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
+
**[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]], [[5yd7]], [[7cjl]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
**[[4d1t]] - PaBlac B Vim-7<br />
**[[4d1t]] - PaBlac B Vim-7<br />
Line 186: Line 215:
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
 +
**[[2x02]], [[7b3r]], [[7b3s]], [[7b3u]] - PaBlac Oxa-10<br />
**[[2x01]] - PaBlac Oxa-10 (mutant)<br />
**[[2x01]] - PaBlac Oxa-10 (mutant)<br />
-
**[[2x02]] - PaBlac Oxa-10<br />
 
**[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br />
**[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br />
**[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br />
**[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br />
 +
**[[6r79]], [[6yi4]] - PaBlac Imp-13 <br />
**[[5b3r]] - PaBlac Imp-18 <br />
**[[5b3r]] - PaBlac Imp-18 <br />
-
**[[5ev6]], [[5y5b]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
+
**[[5ev6]], [[5y5b]], [[7dtm]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
-
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) <br />
+
**[[1wuo]], [[1wup]], [[7dtn]] - SmBlac Imp-1 (mutant) <br />
**[[3vpe]] - SmBlac Smb-1<br />
**[[3vpe]] - SmBlac Smb-1<br />
**[[5fdh]] - SmBlac Oxa-405<br />
**[[5fdh]] - SmBlac Oxa-405<br />
Line 203: Line 233:
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
**[[3r2u]] – SaBlac B<br />
**[[3r2u]] – SaBlac B<br />
-
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]] - KpBlac B Ndm-1<br />
+
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[6c6i]], [[3srx]], [[4h0d]], [[6c6i]], [[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]], [[5xp9]], [[5zgi]], [[5nbk]], [[[6cac]], [[6ex7]], [[6lhe]], [[6twt]] - KpBlac B Ndm-1 + metal ion<br />
-
**[[3srx]], [[6ex7]] - KpBlac B Ndm-1 + Cd <br />
+
**[[5zgf]], [[7ct2]] - KpBlac B Ndm-1 (mutant) + metal ion<br />
-
**[[4h0d]] - KpBlac B Ndm-1 + Mn<br />
+
-
**[[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]], [[5zgi]], [[5nbk]] - KpBlac B Ndm-1 + Zn<br />
+
-
**[[5zgf]] - KpBlac B Ndm-1 (mutant) + Zn<br />
+
-
**[[6cac]] - KpBlac B Ndm-1 + Zn + Co + Cd<br />
+
-
**[[5xp9]] - KpBlac B Ndm-1 + Bi<br />
+
**[[6mh0]] - KpBlac B Ndm-3 + Zn<br />
**[[6mh0]] - KpBlac B Ndm-3 + Zn<br />
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
Line 215: Line 240:
**[[6mgy]] - KpBlac B Ndm-5 + Zn<br />
**[[6mgy]] - KpBlac B Ndm-5 + Zn<br />
**[[6mgx]] - KpBlac B Ndm-6 + Zn<br />
**[[6mgx]] - KpBlac B Ndm-6 + Zn<br />
 +
**[[6r78]] - KpBlac Imp-13 <br />
**[[5n5g]] - PaBlac B Vim-1<br />
**[[5n5g]] - PaBlac B Vim-1<br />
-
**[[3s0z]], [[6c89]] - EcBlac B Ndm-1<br />
+
**[[3s0z]], [[6c89]], [[5zr8]] - EcBlac B Ndm-1<br />
**[[4tz9]] - EcBlac B Ndm-3<br />
**[[4tz9]] - EcBlac B Ndm-3<br />
**[[4tyf]] - EcBlac B Ndm-4<br />
**[[4tyf]] - EcBlac B Ndm-4<br />
Line 222: Line 248:
**[[5wih]] - EcBlac B Ndm-12<br />
**[[5wih]] - EcBlac B Ndm-12<br />
**[[6bm9]] – EcBlac B Vim-2<br />
**[[6bm9]] – EcBlac B Vim-2<br />
 +
**[[7xhx]] - EcBlac Imp-6 <br />
 +
**[[6skp]], [[6skq]], [[6skr]] - EcBlac Oxa-10 <br />
 +
**[[6ovz]] - EcBlac <br />
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
Line 229: Line 258:
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
-
**[[5iqk]] – Blac – uncultured<br />
+
**[[5iqk]], [[7byq]], [[7bz1]], [[7bz3]], [[7bz4]], [[7bzi]] – Blac – uncultured<br />
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
-
**[[6cqs]] – Blac + Zn – Sediminispirochaeta smaragdinae<br />
+
**[[6cqs]] – Blac + Zn – ''Sediminispirochaeta smaragdinae''<br />
 +
**[[6dn4]] – CsBlac – ''Cronobacter sakazakii''<br />
 +
**[[6dq2]], [[6dqh]], [[6dr8]], [[6nc5]] – CsBlac (mutant)<br />
 +
**[[6mfi]] – Blac Mim-2 – ''Simiduia agarivorans''<br />
 +
**[[6t5l]] – Blac B1 Myo-1 – ''Myroides odoratimimus''<br />
 +
**[[6v54]], [[6v5m]], [[6v70]], [[6v71]] – HbBlac (mutant) – ''Hirschia baltica''<br />
 +
**[[6v72]], [[6v73]] – ElBlac – ''Erythrobacter litoralis''<br />
 +
**[[6jv4]] - VaBlac Vmb-1 – ''Vibrio alginolyticus''<br />
*β-lactamase class B binary complex with antibiotic
*β-lactamase class B binary complex with antibiotic
Line 238: Line 274:
**[[5n5i]] - PaBlac B Vim-1 + antibiotic<br />
**[[5n5i]] - PaBlac B Vim-1 + antibiotic<br />
**[[4s2o]], [[5mox]], [[5moz]] - PaBlac Oxa-10 + antibiotic<br />
**[[4s2o]], [[5mox]], [[5moz]] - PaBlac Oxa-10 + antibiotic<br />
 +
**[[6r73]], [[6rzr]], [[6rzs]], [[6s0h]] - PaBlac Imp-13 + antibiotic<br />
**[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br />
**[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br />
**[[4zej]] - PsBlac Dim-1 + antibiotic<br />
**[[4zej]] - PsBlac Dim-1 + antibiotic<br />
-
2aio – StmBlac B + antibiotic
+
**[[2aio]], [[7a63]] – StmBlac B + antibiotic<br />
-
3q6x, 4ey2, 4eyb, 4eyf, 4efl, 4hl1, 4hl2, [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]] – KpBlac B Ndm-1+ antibiotic
+
**[[5zge]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]], ]], [[5o2f]], [[6jkb]] – KpBlac B Ndm-1+ antibiotic<br />
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br />
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypn]] – EcBlac B Ndm-1 + antibiotic<br />
 +
**[[6ol8]] – EcBlac B Ndm-12 + antibiotic<br />
 +
**[[6lf4]] - VaBlac Vmb-1 + antibiotic<br />
*β-lactamase class B binary complex
*β-lactamase class B binary complex
Line 250: Line 289:
**[[1jt1]] – FgBlac + captopril <br />
**[[1jt1]] – FgBlac + captopril <br />
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br />
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br />
-
**[[5n5h]] - PaBlac B Vim-1 + inhibitor<br />
+
**[[5n5h]], [[7afy]], [[7ayj]] - PaBlac B Vim-1 + inhibitor<br />
-
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]] - PaBlac B Vim-2 + inhibitor<br />
+
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]], [[6dd0]], [[6dd1]], [[6j8r]], [[6kxo]], [[6kzn]], [[6sp7]], [[6v1p]], [[6zyn]], [[6zyo]], [[6zyp]], [[7afx]], [[7chv]], [[7du1]]. [[7dub]], [[7due]], [[7duy]], [[7duz]], [[7dv1]], [[7dyy]], [[7dz0]], [[7dz1]] - PaBlac B Vim-2 + inhibitor<br />
 +
**[[6ibs]], [[6ibv]], [[6jn6]], [[6o5t]], [[6rpn]] - PaBlac B Vim-2 + boronic acid inhibitor<br />
 +
**[[7a60]] - PaBlac B Vim-2 + antibiotic<br />
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br />
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br />
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br />
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br />
-
**[[5fq9]] - PaBlac Oxa-10 + inhibitor<br />
+
**[[5fq9]], [[6rtn]] - PaBlac Oxa-10 + inhibitor<br />
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
-
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]] - SmBlac Imp-1+ inhibitor<br />
+
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]], [[6jed]], [[6jka]], [[6lbl]] - SmBlac Imp-1+ inhibitor<br />
 +
**[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br />
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
-
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]] - StmBlac B + inhibitor<br />
+
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]], [[5evk]], [[5evd]], [[5evb]], [[5hh6]], [[5hh5]], [[7afz]] - StmBlac B L1 , [[6xbe]], [[6xbf]], [[6zyq]]+ inhibitor<br />
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br />
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br />
Line 265: Line 307:
**[[5ew0]] - SfBlac B + inhibitor<br />
**[[5ew0]] - SfBlac B + inhibitor<br />
**[[3q6v]] – SfBlac B + glycerol <br />
**[[3q6v]] – SfBlac B + glycerol <br />
-
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]], [[5zjc]], [[5zj8]], [[5zj7]], [[5zj2]], [[5zj1]], [[5zio]], [[5zh1]], [[5zgz]], [[5zgy]], [[5zgx]], [[5zgw]], [[5zgv]] [[5zgu]], [[5zgt]], [[5zgr]], [[5zgq]], [[5zgp]] – KpBlac B Ndm-1+ inhibitor<br />
+
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]], [[5zjc]], [[5zj8]], [[5zj7]], [[5zj2]], [[5zj1]], [[5zio]], [[5zh1]], [[5zgz]], [[5zgy]], [[5zgx]], [[5zgw]], [[5zgv]], [[5zgu]], [[5zgt]], [[5zgr]], [[5zgq]], [[5zgp]], [[6d1a]], [[6d1b]], [[6d1c]], [[6d1d]], [[6d1e]], [[6d1f]], [[6d1g]], [[6d1h]], [[6d1i]], [[6d1j]], [[6d1k]], [[6efj]], [[6mdu]], [[6ny7]], [[6rmf], [[6v1m]], [[6xbe]], [[6xbf]], [[6zyq]] – KpBlac B Ndm-1+ inhibitor<br />
 +
**[[6o3r]] – KpBlac B Ndm-1 (mutant) + inhibitor<br />
 +
**[[6q2y]], [[6q30]] – KpBlac B Ndm-1 + boronic acid inhibitor<br />
**[[5nai]] – KpBlac B Vim-5 + inhibitor<br />
**[[5nai]] – KpBlac B Vim-5 + inhibitor<br />
 +
**[[6kxi]], [[6kzl]] – EcBlac B Ndm-1+ inhibitor<br />
**[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br />
**[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br />
**[[5fqb]] - BcBlac B + inhibitor<br />
**[[5fqb]] - BcBlac B + inhibitor<br />
**[[5evk]], [[5evd]], [[5evb]] - StmBlac B + inhibitor<br />
**[[5evk]], [[5evd]], [[5evb]] - StmBlac B + inhibitor<br />
 +
**[[6v61]] – HbBlac (mutant) + inhibitor<br />
*'''β-lactamase class C'''
*'''β-lactamase class C'''
-
**[[5f1g]], [[5ggw]], [[6g9t]] – EcBlac C<br />
+
**[[5f1g]], [[5ggw]], [[6g9t]], [[6xg1]] – EcBlac C<br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br />
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br />
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
-
**[[3w8k]] – KpBlac C<br />
+
**[[7mqn]] – Blac C –'' Rhodobacter sphaeroides''<br />
 +
**[[3w8k]], [[6k8x]], [[6m5p]] – KpBlac C<br />
 +
**[[6m5h]], [[6m5q]] – KpBlac C (mutant)<br />
**[[4u0t]] – AbBlac C Adc-7<br />
**[[4u0t]] – AbBlac C Adc-7<br />
**[[4qd4]] – AbBlac C Adc-68<br />
**[[4qd4]] – AbBlac C Adc-68<br />
Line 284: Line 332:
*β-lactamase class C binary complex
*β-lactamase class C binary complex
 +
**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]], [[6xfs]] - EcBlac C + inhibitor<br />
**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor<br />
**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor<br />
-
**[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor<br />
+
**[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor<br />
-
**[[3ixh]] - EcBlac C (mutant) + cefotaxime<br />
+
**[[6whf]] - EcBlac C + antibiotic<br />
-
**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor<br />
+
**[[3ixh]] - EcBlac C (mutant) + antibiotic<br />
**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
**[[1rgz]], [[5xhr]] - EncBlac C + antibiotic<br />
**[[1rgz]], [[5xhr]] - EncBlac C + antibiotic<br />
**[1rgy]] - CfBlac C + antibiotic <br />
**[1rgy]] - CfBlac C + antibiotic <br />
-
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
+
**[[1zc2]], [[2zc7]], [[6k9t]], [[6ka5]] – KpBlac C + inhibitor<br />
**[[4wbg]] - KpBlac C + antibiotic<br />
**[[4wbg]] - KpBlac C + antibiotic<br />
 +
**[[6kby]] - KpBlac C + AMP<br />
**[[2wzx]], [[2wzz]], [[6i30]] – PaBlac C + inhibitor<br />
**[[2wzx]], [[2wzz]], [[6i30]] – PaBlac C + inhibitor<br />
**[[4ooy]] - PaBlac C + antibiotic<br />
**[[4ooy]] - PaBlac C + antibiotic<br />
-
**[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]] - AbBlac C Adc-7 + boronic acid inhibitor <br />
+
**[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]], [[6tzf]], [[6tzg]], [[6tzi]], [[6tzj]], [[6wif]] - AbBlac C Adc-7 + boronic acid inhibitor <br />
 +
**[[6pwm]] - AbBlac C + antibiotic<br />
**[[6fm7]] - AeBlac C Tru-1 + inhibitor <br />
**[[6fm7]] - AeBlac C Tru-1 + inhibitor <br />
**[[5k1f]] - EaBlac C + inhibitor <br />
**[[5k1f]] - EaBlac C + inhibitor <br />
Line 308: Line 359:
**[[1g6a]] – PaBlac Pse-4 (mutant) <br />
**[[1g6a]] – PaBlac Pse-4 (mutant) <br />
**[[1ko2]] – PaBlac Vim-2<br />
**[[1ko2]] – PaBlac Vim-2<br />
 +
**[[7l5v]], [[7n1m]] - PaBlac D Oxa-935<br />
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
**[[1m6k]] – EcBlac D<br />
**[[1m6k]] – EcBlac D<br />
-
**[[3hbr]] – KpBlac D Oxa-48<br />
 
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
 +
**[[3hbr]], [[6hoo]], [[7ass]], [[7lxg]] – KpBlac D Oxa-48<br />
 +
**[[6i5d]], [[6rj7]] - KpBlac D Oxa-48 (mutant)<br />
 +
**[[6huh]] - KpBlac D Oxa-427<br />
 +
**[[6hb8]] - KpBlac D Oxa-517<br />
**[[6n6w]], [[6n6t]] - AbBlac D Oxa-23 (mutant)<br />
**[[6n6w]], [[6n6t]] - AbBlac D Oxa-23 (mutant)<br />
**[[4zdx]] - AbBlac D Oxa-51<br />
**[[4zdx]] - AbBlac D Oxa-51<br />
**[[4y0o]] - AbBlac D Oxa-58<br />
**[[4y0o]] - AbBlac D Oxa-58<br />
 +
**[[6t1h]] - AbBlac D Oxa-66<br />
 +
**[[6nz8]] - AbBlac D Oxa-231<br />
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
-
**[[5e2f]] – BsBlac D <br />
+
**[[5e2f]], [[6w5e]] – BsBlac D <br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
**[[6nlw]] – Blac D – ''Shewanella oneidensis''<br />
**[[6nlw]] – Blac D – ''Shewanella oneidensis''<br />
Line 323: Line 380:
**[[6ni0]] – BtBlac D <br />
**[[6ni0]] – BtBlac D <br />
**[[6n1n]] – Blac D – ''Sebaldella termitidis''<br />
**[[6n1n]] – Blac D – ''Sebaldella termitidis''<br />
 +
**[[6ue2]] – Blac D – ''Peptoclostridium difficile''<br />
 +
**[[6wy4]], [[7rl8]] – CdBlac D – ''Clostridium difficile''<br />
 +
**[[7rlr]] – CdBlac D (mutant) <br />
 +
**[[6w5g]] – BaBlac D – ''Bacillus atrophaeus''<br />
 +
**[[6w5o]] – BaBlac D (mutant) <br />
 +
**[[7k3m]] – CpBlac D <br />
*β-lactamase class D binary complex
*β-lactamase class D binary complex
Line 330: Line 393:
**[[3isg]] – EcBlac D + inhibitor<br />
**[[3isg]] – EcBlac D + inhibitor<br />
**[[4s2m]] - EncBlac D Oxa-163+ inhibitor<br />
**[[4s2m]] - EncBlac D Oxa-163+ inhibitor<br />
 +
**[[7khy]], [[7khz]] - EncBlac D Oxa-163 (mutant) + drug<br />
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br />
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br />
**[[6mpq]], [[6b22]] - AbBlac D Oxa-24 + inhibitor<br />
**[[6mpq]], [[6b22]] - AbBlac D Oxa-24 + inhibitor<br />
**[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br />
**[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br />
-
**[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]] [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]] - KpBlac D Oxa-48 + inhibitor<br />
+
**[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]], [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]], [[6uvk]], [[6v1o]], [[7ass]], [[7aux]], [[7aw5]], [[7jhq]], [[7k5v]], [[7l8o]], [[7r6z]] - KpBlac D Oxa-48 + inhibitor<br />
*β-lactamase class D binary complex with antibiotics
*β-lactamase class D binary complex with antibiotics
-
**[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br />
+
**[[1k6r]], [[1k54]], [[7l5t]] - PaBlac D + antibiotic<br />
**[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br />
**[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br />
**[[6n6x]], [[6n6y]], [[6n6v]], [[6n6u]] - AbBlac D Oxa-23 (mutant) + antibiotic<br />
**[[6n6x]], [[6n6y]], [[6n6v]], [[6n6u]] - AbBlac D Oxa-23 (mutant) + antibiotic<br />
 +
**[[7rpg]], [[7rpe]], [[7rpf]] - AbBlac D Oxa-24 + antibiotic<br />
 +
**[[7rp8]], [[7rp9]], [[7rpa]], [[7rpb]], [[7rpc]], [[7rpd]] - AbBlac D Oxa-24 (mutant) + antibiotic<br />
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br />
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br />
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br />
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br />
**[[4x55]] - AbBlac D Oxa-225 (mutant) + antibiotic<br />
**[[4x55]] - AbBlac D Oxa-225 (mutant) + antibiotic<br />
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br />
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br />
-
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br />
+
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]], [[6pqi]], [[6psg]], [[6pt1]], [[6pt5]], [[6ptu]], [[7kh9]], [[7khq]] - KpBlac D Oxa-48 + antibiotic<br />
 +
**[[6pxx]], [[7kh9]] - KpBlac D Oxa-48 (mutant) + antibiotic<br />
 +
**[[7khy]] - KpBlac D Oxa-163 + antibiotic<br />
 +
**[[6xj3]] - KpBlac D + antibiotic<br />
*'''AmpC β-lactamase'''
*'''AmpC β-lactamase'''
-
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]] – EcBlac<br />
+
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]], [[6t3d]], [[7cin]] – EcBlac<br />
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant)
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant)
 +
**[[6lc7]] - EncBlac <br />
 +
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
 +
**[[4net]] – AbBlac<br />
 +
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
 +
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />
 +
 +
*AmpC beta-lactamase binary complex
 +
**[[1fcn]] – EcBlac (mutant) + substrate<br />
**[[1fcn]] – EcBlac (mutant) + substrate<br />
 +
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]], [[6t35]], [[6t5y]], [[6tbw]] - EcBlac + antibiotic<br />
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
-
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]] - EcBlac + antibiotic<br />
+
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]], [[6yeo]], [[6ypd]], [[6t7l]], [[6tpm]] - EcBlac + boronic acid inhibitor<br />
-
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]] - EcBlac + boronic acid inhibitor<br />
+
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]], [[6dpz]], [[6dpy]], [[6dpx]], [[6dpt]] - EcBlac + inhibitor<br />
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]], [[6dpz]], [[6dpy]], [[6dpx]], [[6dpt]] - EcBlac + inhibitor<br />
**[[4jxg]] – EcBlac + oxacillin<br />
**[[4jxg]] – EcBlac + oxacillin<br />
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br />
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br />
 +
**[[6lc8]], [[6lc9]] - EncBlac + inhibitor<br />
**[[4xux]] - EncBlac + boronic acid inhibitor<br />
**[[4xux]] - EncBlac + boronic acid inhibitor<br />
 +
**[[4hef]], [[4nk3]], [[4x68]] - PaBlac + inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
-
**[[4hef]], [[4nk3]], [[4x68]] - PaBlac + inhibitor<br />
+
**[[6s1s]] - PaBlac + boronic acid inhibitor<br />
-
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
+
-
**[[4net]] – AbBlac<br />
+
-
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
+
-
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />
+
*'''Carbapenemase'''
*'''Carbapenemase'''
Line 371: Line 446:
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
-
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br />
+
**[[6p96]] - KpBlac Oxa-48 <br />
-
**[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br />
+
**[[7o5t]], [[7o9n]], [[7peh]] - KpBlac D<br />
-
**[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]] - KpBlac Kpc-2 + inhibitor<br />
+
**[[7pgo]] - KpBlac D (mutant)<br />
-
**[[5uj3]], [[5uj4]] - KpBlac Kpc-2 + antibiotic<br />
+
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc-2
-
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br />
+
**[[6xd5]], [[7ljk]], [[7lk8]], [[7tb7]], [[7tbx]] - KpBlac Kpc-2 (mutant)<br />
-
**[[4eqi]] – SfBlac Sfc-1<br />
+
**[[6qwd]] - KpBlac Kpc-3<br />
-
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
+
**[[6qwe]] - KpBlac Kpc-4<br />
 +
**[[6z21]], [[6z22]] - KpBlac Kpc-4 (mutant)<br />
 +
**[[4eqi]] – SfBlac Sfc-1
**[[4jf5]], [[4jf6]] - AbBlac Oxa-23 <br />
**[[4jf5]], [[4jf6]] - AbBlac Oxa-23 <br />
-
**[[4jf4]] - AbBlac Oxa-23 + antibiotic<br />
 
**[[4oh0]], [[4z9q]] - AbBlac Oxa-58 <br />
**[[4oh0]], [[4z9q]] - AbBlac Oxa-58 <br />
**[[5boh]] - AbBlac Oxa-58 (mutant)<br />
**[[5boh]] - AbBlac Oxa-58 (mutant)<br />
Line 385: Line 461:
**[[1bue]] – EncBlac<br />
**[[1bue]] – EncBlac<br />
**[[4tze]], [[4tzb]] - EcBlac Ndm-5<br />
**[[4tze]], [[4tzb]] - EcBlac Ndm-5<br />
 +
**[[6ogo]] - EcBlac Ndm-9<br />
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
 +
 +
* Carbapenemase binary complexes
 +
 +
**[[6p97]], [[6p98]], [[6p99]], [[6p9c]], [[6pk0]] - KpBlac Oxa-48 + antibiotic<br />
 +
**[[67dml]] - KpBlac Oxa-48 + inhibitor<br />
 +
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br />
 +
**[[5eec]], [[6td1]] - KpBlac Kpc-2 + boronic acid inhibitor<br />
 +
**[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]], [[6d15]], [[6d16]], [[6d17]], [[6d18]], [[6d19]], [[6j8q]], [[6jn3]], [[6jn4]], [[6jn5]], [[6m7i]], [[6mey]], [[6mll]], [[6mnp]], [[6qw9]], [[6td0]], [[6v1j]], [[7vqn]], [[7ti2]] - KpBlac Kpc-2 + inhibitor<br />
 +
**[[5uj3]], [[5uj4]], [[6v7i]], [[7a61]], [[7pep]], [[7tc1]] - KpBlac Kpc-2 + antibiotic<br />
 +
**[[6xd7]], [[6z23]], [[6z25]], [[7llb]], [[7llh]], [[7lnl]], [[7lr9]], [[7pse]], [[7psf]] - KpBlac Kpc-2 (mutant) + antibiotic<br />
 +
**[[6qwa]] - KpBlac Kpc-3 + inhibitor<br />
 +
**[[6qwb]], [[6qwc]] - KpBlac Kpc-4 + inhibitor<br />
 +
**[[6tt8]], [[6ttc]] - KpBlac NDM-1 + inhibitor<br />
 +
**[[6lip]], [[6liz]], [[6lj0]], [[6lj1]], [[6lj2]], [[6lj4]], [[6lj5]], [[6lj6]], [[6lj7]], [[6lj8]] - KpBlac NDM-1 + drug<br />
 +
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
 +
**[[4jf4]] - AbBlac Oxa-23 + antibiotic<br />
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
**[[6mkq]], [[6mk6]] - Blac + inhibitor – ''Vibrio cholerae''<br />
**[[6mkq]], [[6mk6]] - Blac + inhibitor – ''Vibrio cholerae''<br />
 +
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br />
*'''Other β-lactamase'''
*'''Other β-lactamase'''
**[[1bsg]] – Blac – ''Streptomyces albus''<br />
**[[1bsg]] – Blac – ''Streptomyces albus''<br />
 +
**[[6wgr]] - SaBlac <br />
**[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant) <br />
**[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant) <br />
**[[1gce]], [[1xx2]] - EncBlac <br />
**[[1gce]], [[1xx2]] - EncBlac <br />
 +
**[[6op6]], [[6op7]] - EncBlac Vim-20<br />
**[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
**[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
**[[5hfo]] - EcBlac Oxa-232<br />
**[[5hfo]] - EcBlac Oxa-232<br />
Line 399: Line 495:
**[[1fr1]], [[1fr6]] – CfBlac <br />
**[[1fr1]], [[1fr6]] – CfBlac <br />
**[[1i2s]], [[4blm]] – BlBlac<br />
**[[1i2s]], [[4blm]] – BlBlac<br />
-
**[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]] – MtBlac – ''Mycobacterium tuberculosis''<br />
+
**[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]], [[7k8l]] – MtBlac – ''Mycobacterium tuberculosis''<br />
**[[4whi]] – MtBlac C terminal<br />
**[[4whi]] – MtBlac C terminal<br />
-
**[[4jlf]], [[6h28]], [[6h27]] - MtBlac (mutant)<br />
+
**[[4jlf]], [[6h28]], [[6h27]], [[7a5u]], [[7a5w]] - MtBlac (mutant)<br />
**[[2jc7]], [[3g4p]] – AbBlac <br />
**[[2jc7]], [[3g4p]] – AbBlac <br />
**[[3byd]] – KoBlac <br />
**[[3byd]] – KoBlac <br />
Line 423: Line 519:
**[[5oe2]] – KpBlac Oxa-245 <br />
**[[5oe2]] – KpBlac Oxa-245 <br />
**[[6gth]] – KpBlac <br />
**[[6gth]] – KpBlac <br />
 +
**[[7oda]] – Blac Oxa-436 – ''Enterobacter asburiae'' <br />
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br />
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br />
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br />
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br />
**[[6njk]] – Blac – ''Sulfitobacter''<br />
**[[6njk]] – Blac – ''Sulfitobacter''<br />
-
**[[6n9k]] – EcBlac <br />
+
**[[6n9k]], [[6x9y]] – EcBlac <br />
**[[6n36]] – Blac – ''Chitinophaga pinensis''<br />
**[[6n36]] – Blac – ''Chitinophaga pinensis''<br />
**[[6mu9]] – Blac – ''Bacillus megaterium''<br />
**[[6mu9]] – Blac – ''Bacillus megaterium''<br />
**[[6ch0]], [[6cgy]] – AaBlac – ''Alicyclobacillus acidoterrestris''<br />
**[[6ch0]], [[6cgy]] – AaBlac – ''Alicyclobacillus acidoterrestris''<br />
-
 
+
**[[6edm]], [[7lno]], [[7lnr]], [[7me9]] – CdBlac <br />
 +
**[[6izc]] – VpBlac – ''Vibrio parahaemolyticus''<br />
 +
**[[6izd]] – VpBlac (mutant)<br />
 +
**[[6wgp]] – Blac – ''Xanthomonas campestris''<br />
 +
**[[6wgq]] – Blac – ''Shigella flexneri''<br />
 +
**[[6whl]] – Blac – ''Legionella pneumophila''<br />
 +
**[[6wjm]] – Blac – ''Desulfarculus baarsii''<br />
*Other β-lactamase binary complex
*Other β-lactamase binary complex
Line 440: Line 543:
**[[1ga0]] - EncBlac + inhibitor<br />
**[[1ga0]] - EncBlac + inhibitor<br />
**[[1i2w]] – BlBlac + cifoxitin<br />
**[[1i2w]] – BlBlac + cifoxitin<br />
-
**[[3cg5]], [[4q8i]], [[4qb8]] – MtBlac + antibiotic<br />
+
**[[3cg5]], [[4q8i]], [[4qb8]], [[7k8e]], [[7k8f]], [[7k8h]], [[7k8k]] – MtBlac + antibiotic<br />
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]], [[6h2k]], [[6h2i]], [[6h2h]], [[6h2g]], [[6h2c]] – MtBlac + inhibitor<br />
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]], [[6h2k]], [[6h2i]], [[6h2h]], [[6h2g]], [[6h2c]] – MtBlac + inhibitor<br />
Line 448: Line 551:
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br />
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br />
-
**[[6q5b]], [[6q5f]] – KpBlac Oxa-48 (mutant) + avibactam <br />
+
**[[6q5b]], [[6q5f]] – KpBlac Oxa-48 (mutant) + inhibitor<br />
 +
**[[6uqs]], [[6uqt]], [[6uqu]], [[6ur3]] – PaBlac (mutant) + boronic acid inhibitor<br />
**[[6cgz]] – AaBlac + lactone derivative<br />
**[[6cgz]] – AaBlac + lactone derivative<br />
 +
**[[7kep]], [[7keq]], [[7ker]], [[7lnq]], [[7mea]], [[7meb]], [[7mec]], [[7med]], [[7mee]], [[7mef]], [[7meg]], [[7meh]] – CdBlac + drug<br />
 +
**[[6pqc]] – CdBlac (mutant) + antibiotic <br />
 +
**[[7doo]] – BmBlac + antibiotic <br />
 +
**[[7ddm]] – BmBlac + peptide <br />
 +
 +
*Serine beta-lactamase (ClbP)
 +
 +
**[[7mde]], [[7mdf]] – EcClbP (mutant)<br />
 +
**[[7ul6]] – EcClbP – Cryo EM <br />
 +
**[[3o3v]] – EcClbP peptidase domain 38-372<br />
 +
**[[4e6w]], [[4e6x]], [[7mdc]] – EcClbP + boronic acid inhibitor<br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Beta-lactamase

Updated on 30-May-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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