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Beta-lactamase

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'''Beta-lactamase''' (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets.<br />
'''Beta-lactamase''' (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets.<br />
-
*Class A are broad-spectrum<br />
+
*'''Class A''' are broad-spectrum. See also [[TEM1 Class Antibiotic Resistance Proteins]].<br />
-
*Class B are metalloenzymes. <br />
+
*'''Class B''' are metalloenzymes. See also [[New Delhi metallo-β-lactamase 1]].<br />
-
*Class C are cephalosporinases. See also [[Class C beta-lactamase]].<br />
+
*'''Class C''' are cephalosporinases. See also [[Class C beta-lactamase]].<br />
-
*Class D are cloxacilanases<br />
+
*'''Class D''' are cloxacilanases<br />
-
*Carbapenemase (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. <br />
+
*'''Carbapenemase''' (Car) are Blac with wide hydrolytic capacities. Car can hydrolyze penicillins, cephalosporins, monobactams and carbapenems. <br />
-
*Extended-spectrum Blac class A (ESBL) hydrolyze penicillins but not cephalosporins.
+
*'''Extended-spectrum Blac''' class A (ESBL) hydrolyze penicillins but not cephalosporins.<br />
 +
*'''Serine beta-lactamase''' (ClbP) has a serine-active site.
 +
*'''AmpC beta-lactamase''' (ClbP) mediate resistance to cephalosphin, cefazolin,cefoxitin and most penicillins<ref>PMID:19136439</ref>.
== Relevance ==
== Relevance ==
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== Structural highlights ==
== Structural highlights ==
-
The <scene name='45/453531/Cv/2'>active site of class B Blac contains 2 Zn+2 ions</scene>.<ref>PMID:21774017</ref>
+
The <scene name='45/453531/Cv/3'>active site of class B Blac contains 2 Zn+2 ions</scene>.<ref>PMID:21774017</ref>
-
</StructureSection>
+
==See also==
 +
[[Journal:Structure:1]]
== 3D Structures of Beta-lactamase ==
== 3D Structures of Beta-lactamase ==
 +
[[Beta-lactamase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
{{#tree:id=OrganizedByTopic|openlevels=0|
+
-
 
+
-
*'''β-lactamase class A'''
+
-
 
+
-
**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br />
+
-
**[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]] - EcBlac A Tem-1<br />
+
-
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br />
+
-
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br />
+
-
**[[1li0]] - EcBlac A Tem-32 (mutant) <br />
+
-
**[[1li9]] - EcBlac A Tem-34 (mutant) <br />
+
-
**[[1yt4]] - EcBlac A Tem-76 (mutant) <br />
+
-
**[[3toi]] - EcBlac A Tem-116 (mutant)<br />
+
-
**[[5chu]], [[5cgs]] – EcBlac FOX-4<br />
+
-
**[[5cgw]] – EcBlac FOX-4 (mutant)<br />
+
-
**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br />
+
-
**[[4id4]] – EcBlac/PaBlac Tem<br />
+
-
**[[3o3v]] – EcBlac peptidase domain<br />
+
-
**[[1o7e]], [[1n4o]], [[5ne2]] – StmBlac A – ''Stenotrophonas maltophilia''<br />
+
-
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br />
+
-
**[[1shv]], [[4fh4]], [[4fcf]], [[4jpm]] - KpBlac A Shv-1<br />
+
-
**[[1tdl]], [[2a3u]], [[3oph]], [[3opl]], [[3v50]], [[3v5m]], [[4fd8]] - KpBlac A Shv-1 (mutant) <br />
+
-
**[[1n9b]] – KpBlac A Shv-2<br />
+
-
**[[5haq]], [[5hap]] - KpBlac A (mutant) <br />
+
-
**[[2qpn]] – KpBlac A Ges-1<br />
+
-
**[[3ni9]] - PaBlac A Ges-2<br />
+
-
**[[1hzo]] – Blac A – ''Proteus vulgaris''<br />
+
-
**[[1kge]], [[1kgf]], [[1kgg]], [[1ome]] – SaBlac A (mutant) - S''taphylococcus aureus''<br />
+
-
**[[3blm]] – SaBlac A<br />
+
-
**[[1mbl]], [[3ly3]], [[3soi]], [[4n92]], [[5ghx]] – BlBlac A (mutant) – ''Bacillus licheniformis''<br />
+
-
**[[2blm]], [[3sh7]], [[4blm]] – BlBlac A<br />
+
-
**[[2cc1]] – Blac A – ''Mycobacterium fortuitum''<br />
+
-
**[[3bfd]], [[3bfe]] – CsBlac A Sed-1 (mutant) - ''Citrobacter sedlakii''<br />
+
-
**[[3s4x]], [[5har]], [[5hai]] - EncBlac A (mutant) – ''Enterobacter cloacae''<br />
+
-
**[[3zdj]], [[4b88]] – Blac – precambrian<br />
+
-
**[[4c6y]], [[4c75]], [[5fqm]] – Blac – synthetic<br />
+
-
**[[5tfq]] – Blac – ''Bacterioides cellulosilyticus''<br />
+
-
**[[5glc]], [[5gla]], [[5gl9]] - BtBlac A - ''Burkholderia thailandensis''<br />
+
-
**[[4yfm]] – Blac – ''Mycobacterium abscessus''<br />
+
-
 
+
-
*β-lactamase class A binary complex
+
-
 
+
-
**[[1axb]], [[5ksc]] - EcBlac A (mutant) + transition state analog<br />
+
-
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br />
+
-
**[[5ujo]] - EcBlac A (mutant) + organometallics<br />
+
-
**[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br />
+
-
**[[5fa7]] - EcBlac A + inhibitor<br />
+
-
**[[5chm]], [[5chj]], [[5za2]] – EcBlac FOX-4 + antibiotic<br />
+
-
**[[5cgx]] – EcBlac FOX-4 (mutant) + antibiotic<br />
+
-
**[[4zj3]] – EcBlac Tem (mutant) + antibiotic<br />
+
-
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br />
+
-
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br />
+
-
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br />
+
-
**[[1jwv]], [[1jwz]] - EcBlac A Tem-1 (mutant) + boronic acid inhibitor<br />
+
-
**[[1ong]], [[1q2p]], [[1vm1]], [[2h5s]], [[2zd8]], [[3d4f]], [[3mke]], [[3mkf]], [[3mxr]], [[3mxs]], [[4fh2]], [[4gd6]], [[4gd8]], [[4gdb]], [[4mbf]], [[4r3b]], [[5ee8]], [[4zam]] - KpBlac A Shv-1 + inhibitor<br />
+
-
**[[1rcj]], [[1tdg]], [[2a49]], [[2h0t]], [[2h0y]], [[2h10]], [[4mbh]], [[4mbk]] - KpBlac A Shv-1 (mutant) + inhibitor<br />
+
-
**[[3opp]], [[3opr]]- KpBlac A Shv-1 (mutant) + antibiotic<br />
+
-
**[[5t66]] - KpBlac A + boronic acid inhibitor<br />
+
-
**[[1w7f]], [[3b3x]], [[2y91]], [[4a5r]] - BlBlac A + inhibitor<br />
+
-
**[[3m2j]], [[4n9k]], [[4n9l]] - BlBlac A (mutant) + inhibitor<br />
+
-
**[[2wk0]], [[2x71]]– BlBlac A + antibiotic<br />
+
-
**[[3ly4]], [[3m2k]], [[3sh8]], [[3sh9]], [[5ghz]], [[5ghy]] - BlBlac A (mutant) + antibiotic<br />
+
-
**[[4m3k]], [[4n1h]], [[5lwf]] - BlBlac A + antibody<br />
+
-
**[[2q9m]], [[2q9n]] - EncBlac A + inhibitor <br />
+
-
**[[3bfc]], [[3bff]], [[3bfg]] – CsBlac A Sed-1 (mutant) + inhibitor<br />
+
-
**[[3nia]] - PaBlac A Ges-2 + inhibitor<br />
+
-
**[[3p98]] – Blac Tem-72 + citrate – ''Morganella morganii''<br />
+
-
**[[5tg7]], [[5tg6]], [[5tg5]], [[5tg4]] - AbBlac A + boronic acid inhibitor<br />
+
-
**[[5l2f]] - AbBlac A + antibiotic<br />
+
-
**[[5gld]], [[5glb]] - BtBlac A + boronic acid inhibitor <br />
+
-
**[[5ne1]] - StmBlac A + boronic acid inhibitor <br />
+
-
**[[5ne3]] - StmBlac A + antibiotic <br />
+
-
 
+
-
*Extended-spectrum β-lactamase class A
+
-
 
+
-
**[[3ni9]] - PaESBL A GES-2<br />
+
-
**[[4gnu]], [[4h8r]] - PaESBL A GES-5<br />
+
-
**[[5f83]], [[5f82]] - PaESBL A GES-5 (mutant)<br />
+
-
**[[3v3s]] – PaESBL GES-18<br />
+
-
**[[1e25]] – PaESBL PER-1 (mutant)<br />
+
-
**[[5eoe]], [[5eoo]] – PaESBL Bel-1 <br />
+
-
**[[4wz5]] – PaESBL Oxa-10 <br />
+
-
**[[5mmy]], [[5mnu]] – PaESBL Oxa-10 (mutant)<br />
+
-
**[[4yin]] – PaESBL Oxa-145 <br />
+
-
**[[4d2o]] - CfESBL PER-2 – ''Citrobacter freundii''<br />
+
-
**[[5kzh]] - AbESBL A - ''Acinetobacter baumannii''<br />
+
-
**[[3v3r]] - AbESBL A GES-11<br />
+
-
**[[3tsg]] – AbESBL GES-14<br />
+
-
**[[4oqi]], [[4op8]], [[4op5]] - EcESBL Tem-1 (mutant)<br />
+
-
**[[4opy]] - EcESBL Tem-63 (mutant)<br />
+
-
**[[4opr]], [[4opq]] - EcESBL Tem-94 (mutant)<br />
+
-
**[[1ylj]], [[2p74]] – EcESBL Ctx-M-9<br />
+
-
**[[3hre]], [[5kmt]], [[5kmu]], [[5kkf]] - EcESBL Ctx-M-9 (mutant)<br />
+
-
**[[4ua6]] – EcESBL Ctx-M-14 <br />
+
-
**[[1ylt]], [[5vth]], [[5twd]] - EcBlac A Ctx-M-14 (mutant)<br />
+
-
**[[4hbt]] – EcESBL Ctx-M-15<br />
+
-
**[[1ylw]] - EcESBL Ctx-M-16<br />
+
-
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br />
+
-
**[[4c3q]], [[5a93]], [[5a92]], [[5a90]] - EcESBL Ctx-M-97 (mutant)<br />
+
-
**[[6c78]], [[6c79]], [[6c7a]] - EcESBLToho-1 <br />
+
-
**[[1we4]], [[2xr0]], [[2zq7]], [[2zq8]], [[2zq9]], [[2zqa]], [[2zqc]], [[2zqd]], [[4bd0]], [[4bd1]], [[4c3k]] - EcESBLToho-1 (mutant) <br />
+
-
**[[2xqz]], [[2wyx]] - EcESBL Toho-1 (mutant) – Neutron<br />
+
-
**[[3zny]] - KpBlac A Ctx-M-12A (mutant) <br />
+
-
**[[4pm8]] - KpBlac A Ctx-M-14 <br />
+
-
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br />
+
-
**[[2qpn]] – KpESBL A GES-1<br />
+
-
**[[5gs8]] – SmESBL TLA-3 <br />
+
-
 
+
-
*Extended-spectrum β-lactamase class A binary complex
+
-
 
+
-
**[[4gog]] - PaESBL A GES-1 + acyl intermediate<br />
+
-
**[[3nia]] - PaESBL A GES-2 + inhibitor<br />
+
-
**[[4qu3]] - PaESBL A GES-2 + antibiotic<br />
+
-
**[[5eph]], [[5eua]] – PaESBL Bel-1 + antibiotic<br />
+
-
**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br />
+
-
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br />
+
-
**[[1ymx]] - EcESBL Ctx-M-9 + antibiotic<br />
+
-
**[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br />
+
-
**[[4uaa]], [[4ua7]] – EcESBL Ctx-M-14 + inhibitor<br />
+
-
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br />
+
-
**[[5vle]], [[5top]], [[5toy]] - EcESBL Ctx-M-14 (mutant) + ruthenium inhibitor<br />
+
-
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br />
+
-
**[[4hbu]] – EcESBL Ctx-M-15 + inhibitor<br />
+
-
**[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br />
+
-
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br />
+
-
**[[5g18]] - EcESBL Ctx-M-97 + substrate<br />
+
-
**[[4oqh]] - EcESBL Tem-63 (mutant) + boronic acid inhibitor<br />
+
-
**[[4oq0]], [[4opz]] - EcESBL Tem-94 (mutant) + boronic acid inhibitor<br />
+
-
**[[4c3q]], [[4opz]] - EcESBL Toho-1 (mutant) + boronic acid inhibitor - Neutron<br />
+
-
**[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br />
+
-
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br />
+
-
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br />
+
-
**[[5x5g]] – SmESBL TLA-3 + inhibitor<br />
+
-
**[[5gwa]] – SmESBL TLA-3 + antibiotic<br />
+
-
 
+
-
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip)
+
-
 
+
-
**[[3c7u]], [[3c7v]], [[1jtg]], [[2b5r]] – EcBlac A (mutant) + Protein Blip<br />
+
-
**[[1jtd]], [[3gmw]] - EcBlac A + Protein Blip<br />
+
-
**[[1s0w]], [[1xxm]] - EcBlac A + Protein Blip (mutant) <br />
+
-
**[[2g2u]] - KpBlac A Shv-1 + Protein Blip<br />
+
-
**[[2g2w]], [[3n4i]] - KpBlac A Shv-1 (mutant) + Protein Blip<br />
+
-
**[[3c4o]], [[3c4p]] - KpBlac A Shv-1 + Protein Blip (mutant) <br />
+
-
**[[3e2k]], [[3e2l]] - KpBlac A Kpc-2 (mutant) + Protein Blip<br />
+
-
**[[3qhv]], [[3qhy]] - Blac A + Protein Blip – ''Bacillus anthracis''
+
-
 
+
-
*'''β-lactamase class B (Zn containing)'''
+
-
 
+
-
**[[3fcz]], [[3i0v]], [[3i11]], [[3i13]], [[3i14]], [[3i15]], [[1bc2]], [[1bvt]], [[1mqo]], [[2bc2]], [[3bc2]], [[1bmc]], [[4c09]], [[4nq4]], [[5fqa]] – BcBlac B - ''Bacillus cereus''<br />
+
-
**[[2m5c]] - BcBlac B – NMR<br />
+
-
**[[3knr]], [[3kns]], [[1dxk]], [[2bfk]], [[2bfl]], [[2bfz]], [[2bg2]], [[2bg6]], [[2bg7]], [[2bg8]], [[2bga]], [[2nxa]], [[2nyp]], [[2nze]], [[2nzf]], [[2uyx]] - BcBlac B (mutant) <br />
+
-
**[[1a7t]], [[1znb]], [[2bmi]] – BfBlac B – ''Bacterioides fragilis''<br />
+
-
**[[2znb]] - BfBlac B (Cd) <br />
+
-
**[[3znb]] – BfBlac B (Zn, Hg) <br />
+
-
**[[4znb]] - BfBlac B (mutant) <br />
+
-
**[[1k07]] – FgBlac B - ''Fluoribacter gormanii''<br />
+
-
**[[1l9y]] - FgBlac B (mutant) <br />
+
-
**[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br />
+
-
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br />
+
-
**[[4d1t]] - PaBlac B Vim-7<br />
+
-
**[[4d1u]], [[4d1v]], [[4d1w]] - PaBlac B Vim-7 (mutant)<br />
+
-
**[[4awy]], [[4awz]], [[4p62]] - PaBlac B Aim-1<br />
+
-
**[[2ynt]], [[2ynu]], [[2ynv]], [[2ynw]] - PaBlac B Gim-1<br />
+
-
**[[5act]], [[5acs]], [[5acr]], [[5acq]], [[5acp]] - PaBlac B Gim-1 (mutant)<br />
+
-
**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br />
+
-
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br />
+
-
**[[2x01]] - PaBlac Oxa-10 (mutant)<br />
+
-
**[[2x02]] - PaBlac Oxa-10<br />
+
-
**[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br />
+
-
**[[4f6h]], [[4f6z]], [[5ls3]] – PaBlac Imp-1 (mutant)<br />
+
-
**[[5b3r]] - PaBlac Imp-18 <br />
+
-
**[[5ev6]] - SmBlac Imp-1 – ''Serratia marcescens''<br />
+
-
**[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) <br />
+
-
**[[3vpe]] - SmBlac Smb-1<br />
+
-
**[[5fdh]] - SmBlac Oxa-405<br />
+
-
**[[2dkf]], [[2zo4]], [[2zwr]] – TtBlac B – ''Thermus thermophilus''<br />
+
-
**[[2zzi]] – TtBlac B (Fe) <br />
+
-
**[[2fm6]], [[2fu6]], [[2fu7]], [[2h6a]] – StmMlac B<br />
+
-
**[[2qin]], [[2qjs]] - StmBlac B (mutant) <br />
+
-
**[[2gmn]], [[3lvz]] – BjBlac B – ''Bradyrhizobium japonicum''<br />
+
-
**[[2p4z]] – Blac B – ''Thermoanaerobacter tengcongensis''<br />
+
-
**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br />
+
-
**[[3r2u]] – SaBlac B<br />
+
-
**[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]] - KpBlac B Ndm-1<br />
+
-
**[[3srx]], [[6ex7]] - KpBlac B Ndm-1 (Cd) <br />
+
-
**[[4h0d]] - KpBlac B Ndm-1 (Mn)<br />
+
-
**[[5xp6]], [[5n0i]], [[5k4k]], [[5k4m]], [[5k4n]], [[5jqj]] - KpBlac B Ndm-1 (Zn)<br />
+
-
**[[5xp9]] - KpBlac B Ndm-1 (Bi)<br />
+
-
**[[3rkk]], [[4gyq]], [[4gyu]] - KpBlac B Ndm-1 (mutant) <br />
+
-
**[[5wig]] - KpBlac B Ndm-4 (Zn)<br />
+
-
**[[5n5g]] - PaBlac B Vim-1<br />
+
-
**[[3s0z]] - EcBlac B Ndm-1<br />
+
-
**[[4tz9]] - EcBlac B Ndm-3<br />
+
-
**[[4tyf]] - EcBlac B Ndm-4<br />
+
-
**[[4tzf]] - EcBlac B Ndm-8<br />
+
-
**[[5wih]] - EcBlac B Ndm-12<br />
+
-
**[[2yz3]] – Blac Vim-2 – ''Pseudomonas putida''<br />
+
-
**[[3sd9]] – SfBlac B - ''Serratia fonticola''<br />
+
-
**[[4ubq]] - AbBlac Imp-2 <br />
+
-
**[[5mmd]] - AbBlac Tmb-1 <br />
+
-
**[[5a87]] - KpBlac B Vim-5<br />
+
-
**[[4uwo]], [[4uwp]], [[4uwr]], [[4uws]] - KpBlac B Vim-26<br />
+
-
**[[4wd6]] – PsBlac Dim-1 – ''Pseudomonas stutzeri''<br />
+
-
**[[5iqk]] – Blac – uncultured<br />
+
-
**[[5ctn]], [[5ctm]] – Blac – ''Bacillus pumilus''<br />
+
-
**[[4ysb]] – Blac + Fe – ''Myxococcus xanthus''<br />
+
-
 
+
-
*β-lactamase class B binary complex
+
-
 
+
-
**[[1a8t]], [[1hlk]], [[1kr3]] - BfBlac B + inhibitor<br />
+
-
**[[1jt1]] – FgBlac + captopril <br />
+
-
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br />
+
-
**[[5n5h]] - PaBlac B Vim-1 + inhibitor<br />
+
-
**[[5n5i]] - PaBlac B Vim-1 + antibiotic<br />
+
-
**[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]] - PaBlac B Vim-2 + inhibitor<br />
+
-
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br />
+
-
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br />
+
-
**[[4s2o]], [[5mox]], [[5moz]] - PaBlac Oxa-10 + antibiotic<br />
+
-
**[[5fq9]] - PaBlac Oxa-10 + inhibitor<br />
+
-
**[[1m2x]] – Blac B + captopril – ''Elizabethkingia meningoseptica''<br />
+
-
**[[1vgn]], [[3vqz]], [[5hh4]], [[5ewa]], [[5ev8]], [[5axr]] - SmBlac Imp-1+ inhibitor<br />
+
-
**[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br />
+
-
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br />
+
-
**[[4zej]] - PsBlac Dim-1 + antibiotic<br />
+
-
**[[2aio]] – StmBlac B + antibiotic<br />
+
-
**[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]] - StmBlac B + inhibitor<br />
+
-
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br />
+
-
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br />
+
-
**[[5wcm]] – BjBlac B + inhibitor<br />
+
-
**[[2m5d]], [[4c1c]], [[4c1h]], [[4nq5]], [[4nq6]], [[5w8w]], [[4tyt]], [[5jmx]] - BcBlac B + inhibitor<br />
+
-
**[[5ew0]] - SfBlac B + inhibitor<br />
+
-
**[[3q6v]] – SfBlac B + glycerol <br />
+
-
**[[3q6x]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]] – KpBlac B Ndm-1+ antibiotic<br />
+
-
**[[4exy]], [[4exs]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[4u4l]], [[5a5z]], [[5n0h]] – KpBlac B Ndm-1+ inhibitor<br />
+
-
**[[5nai]] – KpBlac B Vim-5 + inhibitor<br />
+
-
**[[5ypi]], [[5ypk]], [[5ypl]], [[5ypm]], [[5ypin] – EcBlac B Ndm-1 + antibiotic<br />
+
-
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br />
+
-
**[[5hh6]], [[5hh5]] - StmBlac B + inhibitor<br />
+
-
**[[5fqb]] - BcBlac B + inhibitor<br />
+
-
**[[5evk]], [[5evd]], [[5evb]] - StmBlac B + inhibitor<br />
+
-
 
+
-
*'''β-lactamase class C'''
+
-
 
+
-
**[[5f1g]], [[5ggw]] – EcBlac C<br />
+
-
**[[3fkw]], [[3iwi]], [[3iwo]], [[3iwq]], [[3ixd]] – EcBlac C (mutant) <br />
+
-
**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – Blac C – ''Enterobacter aerogenes''<br />
+
-
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br />
+
-
**[[3w8k]] – KpBlac C<br />
+
-
**[[4u0t]] – AbBlac C Adc-7<br />
+
-
**[[4qd4]] – AbBlac C Adc-68<br />
+
-
 
+
-
*β-lactamase class C binary complex
+
-
 
+
-
**[[3bm6]], [[3fkv]], [[3o86]], [[3o87]], [[3o88]] – EcBlac C + boronic acid inhibitor<br />
+
-
**[[3ixb]], [[3ixg]] - EcBlac C (mutant) + boronic acid inhibitor<br />
+
-
**[[3ixh]] - EcBlac C (mutant) + cefotaxime<br />
+
-
**[[3gqz]], [[3gr2]], [[3grj]], [[3gsg]], [[3gtc]], [[3gv9]], [[3gvb]] - EcBlac C + inhibitor<br />
+
-
**[[1onh]], [[1q2q]], [[1y54]] - EncBlac C + inhibitor<br />
+
-
**[[1s6r]] - EncBlac C+ boronic acid inhibitor<br />
+
-
**[[1rgz]], [[5xhr]] - EncBlac C + antibiotic<br />
+
-
**[1rgy]] - CfBlac C + antibiotic <br />
+
-
**[[1zc2]], [[2zc7]] – KpBlac C + inhibitor<br />
+
-
**[[4wbg]] - KpBlac C + antibiotic<br />
+
-
**[[2wzx]], [[2wzz]] – PaBlac C + inhibitor<br />
+
-
**[[4ooy]] - PaBlac C + antibiotic<br />
+
-
**[[4u0x]], [[5wac]], [[5wad]], [[5wae]], [[5waf]], [[5wag]], [[5w12]], [[5w13]], [[5w14]] - AbBlac C Adc-7 + boronic acid inhibitor <br />
+
-
 
+
-
*'''β-lactamase class D'''
+
-
 
+
-
**[[2rl3]], [[1k55]], [[1k57]], [[1k4e]], [[1ewz]], [[1fof]], [[1ddk]], [[1e3u]], [[1e4d]], [[1h8z]] – PaBlac D <br />
+
-
**[[2hp5]], [[2hp6]], [[2hp9]], [[2hpb]], [[2wgw]], [[2wki]] - PaBlac D (mutant) <br />
+
-
**[[1k56]], [[2k02]] - PaBlac Pse-2<br />
+
-
**[[1g68]], [[1k4f]] – PaBlac Pse-4<br />
+
-
**[[1g6a]] – PaBlac Pse-4 (mutant) <br />
+
-
**[[1ko2]] – PaBlac Vim-2<br />
+
-
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br />
+
-
**[[1m6k]] – EcBlac D<br />
+
-
**[[3hbr]] – KpBlac D Oxa-48<br />
+
-
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br />
+
-
**[[4zdx]] - AbBlac D Oxa-51<br />
+
-
**[[4y0o]] - AbBlac D Oxa-58<br />
+
-
**[[4s2l]], [[5odz]] - EncBlac D Oxa-163<br />
+
-
**[[5e2f]] – Blac D – ''Bacillus subtilis''<br />
+
-
**[[4ied]] – Blac – ''Fusobacterium nucleatum''<br />
+
-
 
+
-
*β-lactamase class D binary complex
+
-
 
+
-
**[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br />
+
-
**[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br />
+
-
**[[1k6s]] - PaBlac D + phenylboronic acid<br />
+
-
**[[1dd6]], [[1h5x]], [[1h8y]], [[2wgv]] - PaBlac D + inhibitor<br />
+
-
**[[3isg]] – EcBlac D + inhibitor<br />
+
-
**[[4s2m]] - EncBlac D Oxa-163+ inhibitor<br />
+
-
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br />
+
-
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br />
+
-
**[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br />
+
-
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br />
+
-
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br />
+
-
**[[4x55]] - AbBlac D Oxa-225 (mutant) + antibiotic<br />
+
-
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br />
+
-
**[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]] - KpBlac D Oxa-48 + antibiotic<br />
+
-
**[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]] [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]] - KpBlac D Oxa-48 + inhibitor<br />
+
-
 
+
-
*'''AmpC β-lactamase'''
+
-
 
+
-
**[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]] – EcBlac<br />
+
-
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant)
+
-
**[[1fcn]] – EcBlac (mutant) + substrate<br />
+
-
**[[1fco]], [[1i5q]], [[1kvl]], [[4ken]], [[4kg2]], [[4kg5]], [[4kg6]], [[4kz3]], [[4kz4]], [[4kg9]], [[4kz5]], [[4kz6]], [[4kz7]], [[4kz8]], [[4kza]], [[4kzb]] - EcBlac (mutant) + antibiotic<br />
+
-
**[[1iel]], [[1fcm]], [[1iem]], [[1kvm]], [[1ll5]], [[1ll9]], [[1llb]], [[4kz3]], [[4kz4]], [[4okp]], [[4olg]], [[4jxg]] - EcBlac + antibiotic<br />
+
-
**[[1fsw]], [[1fsy]], [[1kds]], [[1kdw]], [[1ke0]], [[1ke3]], [[1mxo]], [[1my8]], [[4e3i]], [[4e3j]], [[4e3k]], [[4e3l]], [[4e3m]], [[4e3n]], [[4e3o]], [[2i72]], [[4lv0]], [[4lv1]], [[4lv2]], [[4lv3]], [[4oqg]] - EcBlac + boronic acid inhibitor<br />
+
-
**[[1pi4]], [[1pi5]], [[2ffy]] - EcBlac (mutant) + boronic acid inhibitor<br />
+
-
**[[1l2s]], [[1xgi]], [[1xgj]], [[2hdq]], [[2hdr]], [[2hds]], [[2hdu]], [[2p9v]], [[2pu2]], [[2pu4]], [[2r9w]], [[2r9x]], [[2rcx]], [[4jxs]], [[4jxv]], [[4jxw]], [[4old]] - EcBlac + inhibitor<br />
+
-
**[[4jxg]] – EcBlac + oxacillin<br />
+
-
**[[1o07]], [[4kz9]] - EcBlac (mutant) + inhibitor<br />
+
-
**[[4xux]] - EncBlac + boronic acid inhibitor<br />
+
-
**[[3s1y]], [[3s22]] - PaBlac (mutant) + inhibitor<br />
+
-
**[[4hef]], [[4nk3]], [[4x68]] - PaBlac + inhibitor<br />
+
-
**[[4gzb]], [[4wz4]], [[4wyy]] – PaBlac<br />
+
-
**[[4net]] – AbBlac<br />
+
-
**[[5e2h]] – Blac – ''Mycobacterium smegmatis''<br />
+
-
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br />
+
-
 
+
-
*'''Carbapenemase'''
+
-
 
+
-
**[[3f9o]] - AhBlac B – ''Aeromonas hydrophila''<br />
+
-
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br />
+
-
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br />
+
-
**[[5eec]] - KpBlac Kpc-2 + boronic acid inhibitor<br />
+
-
**[[4zbe]] - KpBlac Kpc-2 + inhibitor<br />
+
-
**[[5uj3]], [[5uj4]] - KpBlac Kpc-2 + antibiotic<br />
+
-
**[[5mgi]] - KoBlac Kpc-2 + boronic acid inhibitor - ''Klebsiella oxytoca'' <br />
+
-
**[[4eqi]] – SfBlac Sfc-1<br />
+
-
**[[4euz]], [[4ev4]] – SfBlac Sfc-1 (mutant) + antibiotic<br />
+
-
**[[4jf5]], [[4jf6]] - AbBlac OXA-23 <br />
+
-
**[[4jf4]] - AbBlac OXA-23 + antibiotic<br />
+
-
**[[4oh0]], [[4z9q]] - AbBlac OXA-58 <br />
+
-
**[[5boh]] - AbBlac OXA-58 (mutant)<br />
+
-
**[[5iy2]] - AbBlac OXA-143 <br />
+
-
**[[1bue]] – EncBlac<br />
+
-
**[[4tze]], [[4tzb]] - EcBlac Ndm-5<br />
+
-
**[[3dw0]], [[3c5a]] - EcBlac Kpc-2 <br />
+
-
**[[5ll7]] - EcBlac Kpc-2 + boronic acid inhibitor<br />
+
-
 
+
-
*'''Other β-lactamase'''
+
-
 
+
-
**[[1bsg]] – Blac – ''Streptomyces albus''<br />
+
-
**[[1alq]], [[1blp]], [[1dja]], [[1djb]], [[1djc]], [[1ghi]] – SaBlac (mutant) <br />
+
-
**[[1gce]], [[1xx2]] - EncBlac <br />
+
-
**[[4fr7]], [[4fsb]] - EncBlac Vim-31 (mutant)<br />
+
-
**[[5hfo]] - EcBlac Oxa-232<br />
+
-
**[[1dy6]] – SmBlac Sme-1<br />
+
-
**[[1fr1]], [[1fr6]] – CfBlac <br />
+
-
**[[1i2s]], [[4blm]] – BlBlac<br />
+
-
**[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]] – MtBlac – ''Mycobacterium tuberculosis''<br />
+
-
**[[4whi]] – MtBlac C terminal<br />
+
-
**[[4jlf]] - MtBlac (mutant)<br />
+
-
**[[2jc7]], [[3g4p]] – AbBlac <br />
+
-
**[[3byd]] – KoBlac <br />
+
-
**[[3i7j]] – Blac – ''Mycobacterium bovis''<br />
+
-
**[[3lez]] – Blac – ''Oceanobacter iheyensis''<br />
+
-
**[[3p09]] – Blac – ''Francisella tularensis''<br />
+
-
**[[4ewf]] – Blac – ''Sphaerobacter thermophilus''<br />
+
-
**[[3w4o]], [[3w4p]], [[4efz]] – Blac – ''Burkholderia pseudomallei''<br />
+
-
**[[3w4q]] – Blac – ''Burkholderia multivorans''<br />
+
-
**[[5ihv]] – Blac – ''Burkholderia ambifaria''<br />
+
-
**[[5hx9]], [[5hw3]] – Blac – ''Burkholderia vietnamiensis''<br />
+
-
**[[5vpq]] – Blac – ''Burkholderia phymatum''<br />
+
-
**[[5evl]] – Blac – ''Chromobacterterium violaceum''<br />
+
-
**[[5e43]] – Blac – ''Streptoporangium roseum''<br />
+
-
**[[5e2e]] – Blac – ''Yersinia enterocolitica''<br />
+
-
**[[4k0w]] – AbBlac Oxa-23 (mutant)<br />
+
-
**[[4k0x]] – AbBlac Oxa-23 <br />
+
-
**[[5oe0]] – KpBlac Oxa-181 <br />
+
-
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br />
+
-
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br />
+
-
 
+
-
*Other β-lactamase binary complex
+
-
 
+
-
**[[1ghm]], [[1ghp]], [[1pio]] - SaBlac (mutant) + antibiotic<br />
+
-
**[[1blc]], [[1blh]] – SaBlac + inhibitor<br />
+
-
**[[1bls]] – EncBlac + phosphonate derivative <br />
+
-
**[[1bul]] - EncBlac + penicillin derivative<br />
+
-
**[[1ga0]] - EncBlac + inhibitor<br />
+
-
**[[1i2w]] – BlBlac + cifoxitin<br />
+
-
**[[3cg5]], [[4q8i]], [[4qb8]] – MtBlac + antibiotic<br />
+
-
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br />
+
-
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]] – MtBlac + inhibitor<br />
+
-
**[[4x6t]], [[4qhc]] – MtBlac (mutant) + inhibitor<br />
+
-
**[[3vff]], [[3vfh]], [[4ebl]], [[4ebn]], [[4ebp]] – MtBlac (mutant) + intermediate<br />
+
-
**[[3fv7]], [[3fyz]], [[3fzc]], [[3mbz]] – AbBlac + inhibitor<br />
+
-
**[[4wm9]] – AbBlac Oxa-24 + antibiotic <br />
+
-
}}
+
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Class B β-lactamase Ndm-1 complex with Zn+2 (grey) (PDB code 3spu)

Drag the structure with the mouse to rotate

References

  1. ↑ Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82, Table of Contents. PMID:19136439 doi:10.1128/CMR.00036-08
  2. ↑ King D, Strynadka N. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance. Protein Sci. 2011 Sep;20(9):1484-91. doi: 10.1002/pro.697. Epub 2011 Aug, 2. PMID:21774017 doi:10.1002/pro.697

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman

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