Beta-lactamase
From Proteopedia
(Difference between revisions)
| Line 11: | Line 11: | ||
*'''Extended-spectrum Blac''' class A (ESBL) hydrolyze penicillins but not cephalosporins.<br /> | *'''Extended-spectrum Blac''' class A (ESBL) hydrolyze penicillins but not cephalosporins.<br /> | ||
*'''Serine beta-lactamase''' (ClbP) has a serine-active site. | *'''Serine beta-lactamase''' (ClbP) has a serine-active site. | ||
| + | *'''AmpC beta-lactamase''' (ClbP) mediate resistance to cephalosphin, cefazolin,cefoxitin and most penicillins<ref>PMID:19136439</ref>. | ||
== Relevance == | == Relevance == | ||
Current revision
| |||||||||||
References
- ↑ Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82, Table of Contents. PMID:19136439 doi:10.1128/CMR.00036-08
- ↑ King D, Strynadka N. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance. Protein Sci. 2011 Sep;20(9):1484-91. doi: 10.1002/pro.697. Epub 2011 Aug, 2. PMID:21774017 doi:10.1002/pro.697
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman
