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1w51
From Proteopedia
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Revision as of 17:40, 12 November 2007
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BACE (BETA SECRETASE) IN COMPLEX WITH A NANOMOLAR NON-PEPTIDIC INHIBITOR
Overview
Human BACE, also known as beta-secretase, shows promise as a potential, therapeutic target for Alzheimer's disease. We determined the apo, structure of BACE to 1.75 A, and a structure of a hydroxyethylamine, inhibitor complex derived by soaking. These show significant active-site, movements compared to previously described BACE structures. Additionally, the structures reveal two pockets that could be targeted by, structure-based drug design.
About this Structure
1W51 is a Single protein structure of sequence from Homo sapiens with IOD and L01 as ligands. Active as Memapsin 2, with EC number 3.4.23.46 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Apo and inhibitor complex structures of BACE (beta-secretase)., Patel S, Vuillard L, Cleasby A, Murray CW, Yon J, J Mol Biol. 2004 Oct 15;343(2):407-16. PMID:15451669
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Categories: Homo sapiens | Memapsin 2 | Single protein | Cleasby, A. | Murray, C.W. | Patel, S. | Vuillard, L. | Yon, J. | IOD | L01 | Alternative splicing | Alzheimer's disease | Aspartic protease | Aspartyl protease | Base | Beta-secretase | Glycoprotein | Hydrolase | Signal | Transmembrane | Zymogen
