1pid
From Proteopedia
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| - | [[Image:1pid.gif|left|200px]]<br /><applet load="1pid" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1pid, resolution 1.3Å" /> | ||
| - | '''BOVINE DESPENTAPEPTIDE INSULIN'''<br /> | ||
| - | == | + | ==BOVINE DESPENTAPEPTIDE INSULIN== |
| + | <StructureSection load='1pid' size='340' side='right'caption='[[1pid]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1pid]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PID FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pid OCA], [https://pdbe.org/1pid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pid RCSB], [https://www.ebi.ac.uk/pdbsum/1pid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pid ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/INS_BOVIN INS_BOVIN] Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
The crystal structure of despentapeptide insulin, a monomeric insulin, has been refined at 1.3 A spacing and subsequently used to predict and model the organization in the insulin fibril. The model makes use of the contacts in the densely packed despentapeptide insulin crystal, and takes into account other experimental evidence, including binding studies with Congo red. The dimensions of this model fibril correspond well with those measured experimentally, and the monomer-monomer contacts within the fibril are in accordance with the known physical chemistry of insulin fibrils. Using this model, it may be possible to predict mutations in insulin that might alleviate problems associated with fibril formation during insulin therapy. | The crystal structure of despentapeptide insulin, a monomeric insulin, has been refined at 1.3 A spacing and subsequently used to predict and model the organization in the insulin fibril. The model makes use of the contacts in the densely packed despentapeptide insulin crystal, and takes into account other experimental evidence, including binding studies with Congo red. The dimensions of this model fibril correspond well with those measured experimentally, and the monomer-monomer contacts within the fibril are in accordance with the known physical chemistry of insulin fibrils. Using this model, it may be possible to predict mutations in insulin that might alleviate problems associated with fibril formation during insulin therapy. | ||
| - | + | A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin).,Brange J, Dodson GG, Edwards DJ, Holden PH, Whittingham JL Proteins. 1997 Apr;27(4):507-16. PMID:9141131<ref>PMID:9141131</ref> | |
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| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 1pid" style="background-color:#fffaf0;"></div> | |
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| - | + | ==See Also== | |
| + | *[[Insulin 3D Structures|Insulin 3D Structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dodson GG]] | ||
| + | [[Category: Holden PH]] | ||
| + | [[Category: Papiz M]] | ||
Current revision
BOVINE DESPENTAPEPTIDE INSULIN
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