Complement C3

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: <StructureSection load='2xwb' size='340' side='right' caption='Structure of human complement C3b α and β chains complex with complement factor B (PDB code 2xwb).' scene=''> == Func...)
Current revision (08:57, 5 June 2024) (edit) (undo)
 
(19 intermediate revisions not shown.)
Line 1: Line 1:
 +
<StructureSection load='2icf' size='340' side='right' caption='Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code [[2icf]]).' scene='59/594590/Cv/1'>
 +
__TOC__
 +
== Function ==
-
<StructureSection load='2xwb' size='340' side='right' caption='Structure of human complement C3b α and β chains complex with complement factor B (PDB code [[2xwb]]).' scene=''>
+
'''Complement C3''' (CC3) activates the complement system which is part of the immune response. '''CC3''' is proteolytically cleaved by C3 convertase to '''C3a''' (residues 672-748) and '''C3b''' (residues 23-667, 749-1663).
 +
*'''C3a''' is a mediator of local inflammatory processes.
 +
*'''C3b''' binds covalently to cell surface carbohydrates or immune aggregates.
 +
*'''C3c''' is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.<ref>PMID:11414361</ref>
 +
*'''C3d''' is a fragment generated by C3b(residues 996-1287) which binds to antigens enhancing their uptake by B cells<ref>PMID:17337780</ref>.
-
== Function ==
+
<scene name='59/594590/Cv/2'>C3b α and β chains with protein CRIG and Ca+2 ion</scene>.
-
'''Complement C3''' (CC3) activates the complement system which is part of the immune response. CC3 is proteolytically cleaved by C3 convertase to C3a (residues 672-748) and C3b (residues 23-667, 749-1663). C3a is a mediator of local inflammatory processes. C3b binds covalently to cell surface carbohydrates or immune aggregates. Breakdown of C3b generates the fragment C3d (residues 996-1287) which binds to antigens enhancing their uptake by B cells. C3c is another C3b cleavage product residues: 23-664, 749-954, 1321-1663.
+
<scene name='59/594590/Cv/4'>Ca+2 ion coordination site</scene> (PDB code [[2icf]]).<ref>PMID:17051150</ref>
== Disease ==
== Disease ==
 +
 +
A mutation in CC3 cause the progressive kidney disease: dense deposit disease. Other mutations are associated with recurrent bacterial infections.
== Relevance ==
== Relevance ==
-
== Structural highlights ==
+
Low levels of CC3 in the blood are associated with some kidney diseases.
==3D structures of complement C3==
==3D structures of complement C3==
 +
[[Complement C3 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
 
+
-
===CC3===
+
-
 
+
-
[[2a73]] – hCC3 – human <br />
+
-
[[2b39]] – bCC3 – bovine <br />
+
-
 
+
-
===CC3a (anaphylatoxin)===
+
-
 
+
-
[[4hw5]], [[4hwj]], [[4i6o]] – hCC3 <br />
+
-
 
+
-
===CC3b===
+
-
 
+
-
[[2hr0]], [[2i07]] – hCC3 β+α’ chains<br />
+
-
[[2icf]] – hCC3 α+β chains + protein CRIG<br />
+
-
[[3g6j]] – hCC3 α+β chains + antibody<br />
+
-
[[2xwb]] – hCC3 α+β chains + complement factor B<br />
+
-
[[2xwj]] – hCC3 α+β chains (mutant) + complement factor B<br />
+
-
[[2wii]] – hCC3 α+β chains + complement factor H 1-4 sushi domains<br />
+
-
[[3l5n]], [[3ohx]] – hCC3 α+β chains + staphylococcal complement inhibitor<br />
+
-
[[2win]] – hCC3 α+β chains + complement factor B BB fragment + staphylococcal complement inhibitor<br />
+
-
 
+
-
===CC3c===
+
-
 
+
-
[[2a74]] – hCC3 <br />
+
-
[[2qki]] – hCC3 + compstatin <br />
+
-
[[3l3o]], [[3nms]] – hCC3 + staphylococcal complement inhibitor<br />
+
-
[[2ice]] – hCC3 α+β chains + protein CRIG<br />
+
-
[[3t4a]] – hCC3 α+β chains + fibrinogen-binding protein <br />
+
-
 
+
-
===CC3d===
+
-
 
+
-
[[1c3d]] – hCC3 (mutant) <br />
+
-
[[1w2s]], [[3oed]] – hCC3 1-2 sushi domains + complement receptor type 2 precursor<br />
+
-
[[2gox]], [[3d5r]], [[3d5s]] – hCC3 α chain fragment + fibrinogen-binding protein <br />
+
-
[[2noj]] – hCC3 α chain fragment (mutant) + EFB homologous protein <br />
+
-
[[2wy7]], [[2wy8]] – hCC3 α chain fragment (mutant) + IGG-binding protein <br />
+
-
[[3oxu]] – hCC3 α chain fragment (mutant) + HF protein <br />
+
-
[[4m76]] – hCC3 α chain fragment (mutant) + integrin α-M <br />
+
-
[[2xqw]] – hCC3 + complement factor H 19-20 sushi domains<br />
+
-
[[3rj3]] – hCC3 α chain fragment + complement factor H-related protein<br />
+
-
[[1qqf]] – rCC3 G fragment - rat <br />
+
-
[[1qsj]] – rCC3 G fragment (mutant) <br />
+
-
 
+
-
 
+
-
 
+
-
 
+
-
 
+
== References ==
== References ==

Current revision

Structure of human glycosylated complement C3b α (magenta) and β (salmon) chains complex with protein CRIG (cyan) and Ca+2 ion (green) (PDB code 2icf).

Drag the structure with the mouse to rotate

References

  1. ↑ Sahu A, Lambris JD. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev. 2001 Apr;180:35-48. PMID:11414361
  2. ↑ Toapanta FR, Ross TM. Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunity. Immunol Res. 2006;36(1-3):197-210. PMID:17337780 doi:10.1385/IR:36:1:197
  3. ↑ Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature. 2006 Nov 9;444(7116):217-20. Epub 2006 Oct 15. PMID:17051150 doi:10.1038/nature05263

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Complement_C3"
Personal tools