Complement factor

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== Function ==
== Function ==
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'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement)<ref>PMID:15163532</ref>. '''Complement factor D''' (CFD) and '''Complement factor B''' (CFB) regulate a key step in the activation of the alternative complement pathway. CFD is a member of the chymotrypsin family of serine proteases. '''Complement factor I''' (CFI) is a serum protease that inhibits all complement pathways.
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*'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement)<ref>PMID:15163532</ref>.
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*'''Complement factor D''' (CFD) and '''Complement factor B''' (CFB) regulate a key step in the activation of the alternative complement pathway. CFD is a member of the chymotrypsin family of serine proteases.
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*'''Complement factor I''' (CFI) is a serum protease that inhibits all complement pathways.
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*'''Complement factor P''' (CFP) is a positive regulator of the alternative complement pathway<ref>PMID:28480349</ref>.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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The <scene name='59/594535/Cv/3'>sushi domains are ca. 60 amino acid long containing 2 Cys-Cys bonds</scene>.
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The <scene name='59/594535/Cv/5'>sushi domains are ca. 60 amino acid long containing 2 Cys-Cys bonds</scene>.
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*<scene name='59/594535/Cv/4'>Cys-Cys bonds</scene>.
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*<scene name='59/594535/Cv/6'>Cys-Cys bonds</scene>.
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</StructureSection>
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==3D structures of complement factor==
==3D structures of complement factor==
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[[Complement factor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Complement factor H
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**[[1haq]], [[3gau]], [[3gav]], [[3gaw]] – hCFH – human - NMR<br />
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**[[2rlp]] – hCFH 1-2 sushi domains - NMR <br />
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**[[2rlq]] – hCFH 2-3 sushi domains - NMR <br />
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**[[2qfg]] – hCFH 1-5 sushi domains <br />
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**[[2yby]] – mCFH 6-8 sushi domains (mutant) - mouse<br />
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**[[2ic4]] – hCFH 6-8 sushi domains (mutant) <br />
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**[[2jgw]] – hCFH 7 sushi domain – NMR<br />
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**[[2jgx]] – hCFH 7 sushi domain (mutant) <br />
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**[[4b2r]] – hCFH 10-11 sushi domains - NMR <br />
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**[[4b2s]] – hCFH 11-12 sushi domains - NMR <br />
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**[[2kms]] – hCFH 12-13 sushi domains – NMR<br />
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**[[1hfi]] – hCFH 15 sushi domain – NMR<br />
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**[[1hfh]] – hCFH 15-16 sushi domains – NMR<br />
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**[[2qfh]] – hCFH 16-20 sushi domains - NMR <br />
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**[[3sw0]] – hCFH 18-20 sushi domains <br />
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**[[2bzm]] – hCFH 19-20 sushi domains – NMR<br />
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**[[3kzj]] – hCFH 19-20 sushi domains (mutant) – NMR<br />
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**[[2g7i]] – hCFH 19-20 sushi domains <br />
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**[[3kxv]], [[3r62]] – hCFH 19-20 sushi domains (mutant) <br />
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*Complement factor H complexes
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**[[2wii]] – hCFH 1-4 sushi domains + complement C3 <br />
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**[[2w80]], [[2w81]], [[4ayd]], [[4aye]], [[4ayi]], [[4aym]] – hCFH 6-7 sushi domains + factor H binding protein <br />
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**[[2uwn]], [[2v8e]] – hCFH 6-8 sushi domains + sucrose octasulfate <br />
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**[[4k12]] – hCFH 9 sushi domain + choline binding protein A <br />
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**[[3oxu]], [[4ont]], [[4zh1]] – hCFH 19-20 sushi domains + complement C3 <br />
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**[[2xqw]] – hCFH 19-20 sushi domains (mutant) + complement C3 <br />
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**[[4j38]] – hCFH 19-20 sushi domains (mutant) + outer surface protein E <br />
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**[[4k12]] – hCFH 9 sushi domain + choline binding protein A <br />
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**[[5nbq]] – hCFH + complement C3 a chain + outer surface protein<br />
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**[[5o32]] – hCFH + hCFI + complement C3 a+b chains <br />
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**[[5o35]] – hCFH + complement C3 a chain <br />
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*Complement factor B
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**[[2ok5]] – hCFB residues 26-764<br />
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**[[1dle]] – hCFB serine protease domain residues 470-764<br />
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**[[1q0p]] – hCFB residues 254-476 (mutant) <br />
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**[[1rrk]] – hCFB BB fragment residues 243-764 (mutant) <br />
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*Complement factor B complexes
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**[[1rs0]] – hCFB BB fragment (mutant) + DIP<br />
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**[[1rtk]] – hCFB BB fragment (mutant) + guanidinobenzoate<br />
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**[[2xwb]] – hCFB (mutant) + hCFD (mutant) + complement C3B a’+b chains<br />
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**[[2xwj]] – hCFB (mutant) + complement C3 a+b chains<br />
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**[[3hrz]], [[3hs0]] – hCFB (mutant) + cobra venom factor<br />
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*Complement factor D
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**[[1dsu]], [[1hfd]] – hCFD <br />
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**[[1dst]], [[2xw9]], [[2xwa]], [[4cbn]], [[4cbo]] – hCFD (mutant) <br />
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**[[1fdp]] – hCFD proenzyme <br />
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*Complement factor D complexes
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**[[1bio]], [[1dfp]], [[1dic]], [[5fbe]], [[5fbi]], [[5fck]], [[5fcr]], [[5mt0]], [[5mt4]], [[5nar]], [[5nat]], [[5naw]], [[5nb6]], [[5nb7]], [[5nba]], [[5tca]], [[5tcc]] – hCFD + inhibitor <br />
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**[[4d9r]] – hCFD + antibody<br />
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*Complement factor I
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**[[2xrc]] – hCFI <br />
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}}
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== References ==
== References ==

Current revision

Structure of human complement factor H 19-20 sushi domains (magenta) complex with complement C3 (green) and glycerol (PDB code 3oxu).

Drag the structure with the mouse to rotate

References

  1. ↑ Rodriguez de Cordoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sanchez-Corral P. The human complement factor H: functional roles, genetic variations and disease associations. Mol Immunol. 2004 Jun;41(4):355-67. PMID:15163532 doi:10.1016/j.molimm.2004.02.005
  2. ↑ Narni-Mancinelli E, Gauthier L, Baratin M, Guia S, Fenis A, Deghmane AE, Rossi B, Fourquet P, Escaliere B, Kerdiles YM, Ugolini S, Taha MK, Vivier E. Complement factor P is a ligand for the natural killer cell-activating receptor NKp46. Sci Immunol. 2017 Apr 28;2(10). doi: 10.1126/sciimmunol.aam9628. PMID:28480349 doi:http://dx.doi.org/10.1126/sciimmunol.aam9628
  3. ↑ Stanton CM, Yates JR, den Hollander AI, Seddon JM, Swaroop A, Stambolian D, Fauser S, Hoyng C, Yu Y, Atsuhiro K, Branham K, Othman M, Chen W, Kortvely E, Chalmers K, Hayward C, Moore AT, Dhillon B, Ueffing M, Wright AF. Complement factor D in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2011 Nov 11;52(12):8828-34. doi: 10.1167/iovs.11-7933. PMID:22003108 doi:http://dx.doi.org/10.1167/iovs.11-7933
  4. ↑ Alexander P, Gibson J, Cree AJ, Ennis S, Lotery AJ. Complement factor I and age-related macular degeneration. Mol Vis. 2014 Sep 13;20:1253-7. eCollection 2014. PMID:25352734
  5. ↑ Coan PM, Barrier M, Alfazema N, Carter RN, Marion de Proce S, Dopico XC, Garcia Diaz A, Thomson A, Jackson-Jones LH, Moyon B, Webster Z, Ross D, Moss J, Arends MJ, Morton NM, Aitman TJ. Complement Factor B Is a Determinant of Both Metabolic and Cardiovascular Features of Metabolic Syndrome. Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09242. doi:, 10.1161/HYPERTENSIONAHA.117.09242. PMID:28739975 doi:http://dx.doi.org/10.1161/HYPERTENSIONAHA.117.09242

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