1soo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1soo.jpg|left|200px]]
[[Image:1soo.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1soo |SIZE=350|CAPTION= <scene name='initialview01'>1soo</scene>, resolution 2.6&Aring;
+
The line below this paragraph, containing "STRUCTURE_1soo", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=H5P:HYDANTOCIDIN-5&#39;-PHOSPHATE'>H5P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1soo| PDB=1soo | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1soo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1soo OCA], [http://www.ebi.ac.uk/pdbsum/1soo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1soo RCSB]</span>
+
-
}}
+
'''ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE'''
'''ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE'''
Line 27: Line 24:
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Cowan-Jacob, S W.]]
[[Category: Cowan-Jacob, S W.]]
-
[[Category: gtp-hydrolyzing enzyme]]
+
[[Category: Gtp-hydrolyzing enzyme]]
-
[[Category: herbicide]]
+
[[Category: Herbicide]]
-
[[Category: ligase]]
+
[[Category: Ligase]]
-
[[Category: purine nucleotide biosynthesis]]
+
[[Category: Purine nucleotide biosynthesis]]
-
[[Category: synthetase]]
+
[[Category: Synthetase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 08:57:34 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:44:57 2008''
+

Revision as of 05:57, 3 May 2008

Image:1soo.jpg

Template:STRUCTURE 1soo

ADENYLOSUCCINATE SYNTHETASE INHIBITED BY HYDANTOCIDIN 5'-MONOPHOSPHATE


Overview

(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate to the target enzyme was analyzed by determining the crystal structure of the enzyme-inhibitor complex at 2.6-A resolution. It was found that adenylosuccinate synthetase binds the phosphorylated compound in the same fashion as it does adenosine 5'-monophosphate, the natural feedback regulator of this enzyme. This work provides the first crystal structure of a herbicide-target complex reported to date.

About this Structure

1SOO is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase., Fonne-Pfister R, Chemla P, Ward E, Girardet M, Kreuz KE, Honzatko RB, Fromm HJ, Schar HP, Grutter MG, Cowan-Jacob SW, Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9431-6. PMID:8790347 Page seeded by OCA on Sat May 3 08:57:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1soo"
Personal tools