Ectonucleoside triphosphate diphosphohydrolase
From Proteopedia
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'''Ectonucleoside triphosphate diphosphohydrolase (NTPDase)''' hydrolyzes nucleoside 5’-triphosphate to nucleoside 5’-phosphate and 2 phosphates. NTPDase can hydrolyze ATP and ADP. NTPDase has an important role in regulating neutrophil chemotaxis. NTPDase 1,2,3,8 are cell surface enzymes with catalytic sites facing extracellularly while other NTPDases act intracellularly. NTPDase require Ca<sup>+2</sup> or Mg<sup>+2</sup> for their activity. The NTPDases can be differentiated according to their substrate specificity, divalent cation usage and product formation.<ref>PMID:23830739</ref> | '''Ectonucleoside triphosphate diphosphohydrolase (NTPDase)''' hydrolyzes nucleoside 5’-triphosphate to nucleoside 5’-phosphate and 2 phosphates. NTPDase can hydrolyze ATP and ADP. NTPDase has an important role in regulating neutrophil chemotaxis. NTPDase 1,2,3,8 are cell surface enzymes with catalytic sites facing extracellularly while other NTPDases act intracellularly. NTPDase require Ca<sup>+2</sup> or Mg<sup>+2</sup> for their activity. The NTPDases can be differentiated according to their substrate specificity, divalent cation usage and product formation.<ref>PMID:23830739</ref> | ||
*'''NTPDase 1''' hydrolyzes ATP released by neutrophils<ref>PMID:18713747</ref>. | *'''NTPDase 1''' hydrolyzes ATP released by neutrophils<ref>PMID:18713747</ref>. | ||
| + | *'''NTPDase 2''' hydrolyzes extracellular ATP <ref>PMID:35593054</ref>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 09:06, 16 June 2024
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3D structures of ectonucleoside triphosphate diphosphohydrolase
Updated on 16-June-2024
References
- ↑ Zebisch M, Krauss M, Schafer P, Lauble P, Strater N. Crystallographic Snapshots along the Reaction Pathway of Nucleoside Triphosphate Diphosphohydrolases. Structure. 2013 Jul 2. pii: S0969-2126(13)00200-1. doi:, 10.1016/j.str.2013.05.016. PMID:23830739 doi:10.1016/j.str.2013.05.016
- ↑ Corriden R, Chen Y, Inoue Y, Beldi G, Robson SC, Insel PA, Junger WG. Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem. 2008 Oct 17;283(42):28480-6. PMID:18713747 doi:10.1074/jbc.M800039200
- ↑ Dragic M, Mihajlovic K, Adzic M, Jakovljevic M, Kontic MZ, Mitrović N, Laketa D, Lavrnja I, Kipp M, Grković I, Nedeljkovic N. Expression of Ectonucleoside Triphosphate Diphosphohydrolase 2 (NTPDase2) Is Negatively Regulated Under Neuroinflammatory Conditions In Vivo and In Vitro. ASN Neuro. 2022 Jan-Dec;14:17590914221102068. PMID:35593054 doi:10.1177/17590914221102068
