8fz5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8fz5 is ON HOLD Authors: Hsu, H.-C., Li, H. Description: The PI31-free Bovine 20S proteasome Category: Unreleased Structures [[Category: Li, H]...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The PI31-free Bovine 20S proteasome== |
| - | + | <StructureSection load='8fz5' size='340' side='right'caption='[[8fz5]], [[Resolution|resolution]] 2.23Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8fz5]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FZ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FZ5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.23Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fz5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fz5 OCA], [https://pdbe.org/8fz5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fz5 RCSB], [https://www.ebi.ac.uk/pdbsum/8fz5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fz5 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Hsu | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PSA6_BOVIN PSA6_BOVIN] Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).[UniProtKB:P60900] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hsu H-C]] | ||
| + | [[Category: Li H]] | ||
Current revision
The PI31-free Bovine 20S proteasome
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