Monooxygenase 3D structures

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Line 40: Line 40:
**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
**[[4nl5]] – MtMO + heme + CN – ''Mycobacterium tuberculosis''<br />
**[[4nl5]] – MtMO + heme + CN – ''Mycobacterium tuberculosis''<br />
 +
**[[6ds7]] - MtHO (mutant) + heme <br />
 +
**[[6ds8]] – MtMO (mutant) + heme-Mn <br />
**[[4oz5]] – MO + heme – ''Bacillus subtilis''<br />
**[[4oz5]] – MO + heme – ''Bacillus subtilis''<br />
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**[[5x68]] – hKMO + FAD - human<br />
**[[5x68]] – hKMO + FAD - human<br />
 +
**[[6lkd]], [[6lke]] – rKMO + FAD + inhibitor - rat<br />
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
-
**[[4j36]], [[5x64]] – yKMO + FAD + inhibitor<br />
+
**[[4j36]], [[5x6r]] – yKMO + FAD + inhibitor<br />
**[[5x6q]] – yKMO (mutant) + FAD + inhibitor<br />
**[[5x6q]] – yKMO (mutant) + FAD + inhibitor<br />
**[[5na5]], [[5x6p]] – PfKMO (mutant) + FAD – ''Pseudomonas fluorescens''<br />
**[[5na5]], [[5x6p]] – PfKMO (mutant) + FAD – ''Pseudomonas fluorescens''<br />
Line 63: Line 66:
**[[5pah]], [[6pah]] – hFMO catalytic domain + inhibitor <br />
**[[5pah]], [[6pah]] – hFMO catalytic domain + inhibitor <br />
- 
-
*'''Phenylalanine 4-monooxygenase''' or phenylalanine-4-hydroxylase
 
- 
-
See [[Hydroxylase]]
 
*'''ActVA-Orf6 monooxygenase (AOMO)'''
*'''ActVA-Orf6 monooxygenase (AOMO)'''
Line 75: Line 74:
**[[1n5v]] – ScAOMO + nanaomycine <br />
**[[1n5v]] – ScAOMO + nanaomycine <br />
-
*Baeyer-Villiger monooxygenase (BVMO)
+
*'''Baeyer-Villiger monooxygenase (BVMO)'''
-
**[[6jdk]] – BVMO – ''Parvibaculum lavamentivorans''<br />
+
**[[6jdk]] – BVMO + FAD – ''Parvibaculum lavamentivorans''<br />
 +
**[[6y48]] – BVMO + FAD + NADP – ''Aspergillus flavus''<br />
*'''Flavin-containing monooxygenase'''
*'''Flavin-containing monooxygenase'''
 +
**[[6wpu]] – MO + FAD – garlic<br />
**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
Line 101: Line 102:
**[[5nmw]] – ZvMO + FAD – ''Zonocerus variegatus''<br />
**[[5nmw]] – ZvMO + FAD – ''Zonocerus variegatus''<br />
**[[5nmx]] – ZvMO + FAD + NADP <br />
**[[5nmx]] – ZvMO + FAD + NADP <br />
 +
**[[6kbw]] – MO + FAD + NADP – ''Myroides profundi''<br />
 +
**[[6se3]], [[6sek]], [[6sem]], [[6sf0]] – MO + FAD + NADP + O2 – synthetic<br />
 +
**[[6u0p]] – StMO + FAD – ''Streptomyces''<br />
 +
**[[6u0s]] – StMO + FAD + pyridine derivative<br />
 +
**[[7d4k]], [[7d4m]], [[7d4n]] – MO + FAD + NADP – ''Candidatus pelagibacter''<br />
 +
**[[6sem]] – anMO + FAD - ancestral<br />
 +
**[[6se3]], [[6sek]], [[6sf0]], [[7al4]] – anMO + FAD + NADP <br />
 +
**[[6hns]] – MO + FAD + NADP – ''Nitricola lacisaponensis''<br />
-
*2,4,6-trichlorophenol 4-monooxygenase
+
*'''2,4,6-trichlorophenol 4-monooxygenase'''
**[[4g5e]] – MO – ''Cupriavidus necator''<br />
**[[4g5e]] – MO – ''Cupriavidus necator''<br />
-
*Chlorophenol 4-monooxygenase
+
*'''Chlorophenol 4-monooxygenase'''
**[[4oo2]] – MO – ''Streptomyces globisporus''<br />
**[[4oo2]] – MO – ''Streptomyces globisporus''<br />
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**[[3k87]] – BcMO + FAD <br />
**[[3k87]] – BcMO + FAD <br />
**[[3k88]] – BcMO + FAD + NAD <br />
**[[3k88]] – BcMO + FAD + NAD <br />
 +
**[[6jhm]] – MO – ''Ralstonia pickettii''<br />
 +
**[[7e8p]], [[7e8q]] – RpMO + FAD derivative + nitrophenol <br />
-
*Phenylacetone monooxygenase
+
*'''Phenylacetone monooxygenase'''
**[[4ovi]], [[4c74]] – TfMO + FAD + APADP – ''Thermobifida fusca''<br />
**[[4ovi]], [[4c74]] – TfMO + FAD + APADP – ''Thermobifida fusca''<br />
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**[[2ym1]] – TfMO (mutant) + FAD + NADP + O2<br />
**[[2ym1]] – TfMO (mutant) + FAD + NADP + O2<br />
-
*6-hydroxynicotinate 3-monooxygenase
+
*'''6-hydroxynicotinate 3-monooxygenase'''
**[[5eow]] – PpMO + FAD – ''Pseudomonas putida''<br />
**[[5eow]] – PpMO + FAD – ''Pseudomonas putida''<br />
-
*Styrene monooxygenase
+
*'''Styrene monooxygenase'''
**[[3ihm]] – PpMO <br />
**[[3ihm]] – PpMO <br />
**[[4f07]] – PpMO (mutant) + FAD <br />
**[[4f07]] – PpMO (mutant) + FAD <br />
-
*Tryptophan 2-monooxygenase
+
*'''Tryptophan 2-monooxygenase'''
**[[4iv9]] – MO + FAD – ''Pseudomonas savastanoi''<br />
**[[4iv9]] – MO + FAD – ''Pseudomonas savastanoi''<br />
-
*Tryptophan 5-monooxygenase
+
*'''Tryptophan 5-monooxygenase'''
**[[1mlw]] – hMO + Fe + dihydrobiopterin <br />
**[[1mlw]] – hMO + Fe + dihydrobiopterin <br />
-
*Tyrosine 3-monooxygenase
+
*'''Tyrosine 3-monooxygenase'''
**[[2xsn]] – hMO + Zn<br />
**[[2xsn]] – hMO + Zn<br />
-
**[[2toh]] – rMO + Fe + dihydrobiopterin + tyrosine - rat<br />
+
**[[2toh]] – rMO + Fe + dihydrobiopterin + tyrosine y<br />
**[[2mda]] – rMO regulatory domain <br />
**[[2mda]] – rMO regulatory domain <br />
-
*Nitronate monooxygenase
+
*'''Nitronate monooxygenase'''
**[[4q4k]] – PaMO + FMN <br />
**[[4q4k]] – PaMO + FMN <br />
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**[[6bka]] – MO + FMN – ''Cyberlyndnera mrakii''<br />
**[[6bka]] – MO + FMN – ''Cyberlyndnera mrakii''<br />
-
*2-hydroxbiphenyl 3-monooxygenase
+
*'''2-hydroxybiphenyl 3-monooxygenase'''
-
**[[4z2r]] – PnMO + FAD – ''Pseudomonas nitroreducens''<br />
+
**[[4z2r]], [[6em0]] – PnMO + FAD – ''Pseudomonas nitroreducens''<br />
**[[4cy6]] – PnMO (mutant) <br />
**[[4cy6]] – PnMO (mutant) <br />
-
**[[4z2u]], [[4z2t]], [[4cy8]] – PnMO (mutant) + FAD <br />
+
**[[4z2u]], [[4z2t]], [[4cy8]], [[6em0]] – PnMO (mutant) + FAD <br />
**[[5brt]] – PnMO + FAD + hydroxybephenyl <br />
**[[5brt]] – PnMO + FAD + hydroxybephenyl <br />
-
*4-hydroxyphenylacetate 3-monooxygenase
+
*'''4-hydroxyphenylacetate 3-monooxygenase'''
**[[4ira]] – BmMO + FAD – ''Brucella melitensis''<br />
**[[4ira]] – BmMO + FAD – ''Brucella melitensis''<br />
**[[3cb0]] – BmMO + FMN<br />
**[[3cb0]] – BmMO + FMN<br />
-
**[[6eb0]] – EcMO oxygenase subunit<br />
+
**[[6eb0]], [[6qyh]] – EcMO oxygenase subunit<br />
**[[6b1b]] – EcMO oxygenase subunit (mutant)<br />
**[[6b1b]] – EcMO oxygenase subunit (mutant)<br />
 +
**[[6qyi]] – EcMO oxygenase subunit + FAD<br />
-
*Ornithine N(5)-monooxygenase
+
*'''Ornithine N(5)-monooxygenase'''
-
**[[5cku]] – MO + FAD + NADP + ornithine – ''Neosartorya fumigata''<br />
+
**[[6x0i]] – NfMO + FAD + NADP – ''Neosartorya fumigata''<br />
-
**[[4nzh]], [[4b69]] – AfMO + FAD + ornithine – ''Aspergillus fumigatus''<br />
+
**[[5cku]] – NfMO + FAD + NADP + ornithine <br />
-
**[[4b65]] – AfMO + FAD + NADP <br />
+
**[[6x0h]] – AfMO (mutant) + FAD – ''Aspergillus fumigatus''<br />
 +
**[[4nzh]], [[4b69]] – AfMO + FAD + ornithine <br />
 +
**[[6x0k]] – AfMO (mutant) + FAD + ornithine <br />
 +
**[[6x0h]], [[7jvk]] – AfMO (mutant) + FAD <br />
 +
**[[4b65]], [[6x0i]] – AfMO + FAD + NADP <br />
 +
**[[7jvl]] – AfMO (mutant) + FAD + NADP <br />
**[[4b68]], [[4b66]] – AfMO + FAD + NAP + arginine <br />
**[[4b68]], [[4b66]] – AfMO + FAD + NAP + arginine <br />
**[[4b67]], [[4b63]] – AfMO + FAD + NADP + ornithine <br />
**[[4b67]], [[4b63]] – AfMO + FAD + NADP + ornithine <br />
 +
**[[6x0j]] – AfMO (mutant) + FAD + NADP + ornithine <br />
**[[4b64]] – AfMO + FAD + NADP + lysine <br />
**[[4b64]] – AfMO + FAD + NADP + lysine <br />
**[[3s61]] – PaMO + FAD + NADP + ornithine derivative<br />
**[[3s61]] – PaMO + FAD + NADP + ornithine derivative<br />
-
*Steroid monooxygenase
+
*'''Steroid monooxygenase'''
**[[4ap1]], [[4aos]] – RrMO + FAD + NADP – ''Rhodococcus rhodochrous''<br />
**[[4ap1]], [[4aos]] – RrMO + FAD + NADP – ''Rhodococcus rhodochrous''<br />
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**[[4ap3]] – RrMO (mutant) + FAD + NADP <br />
**[[4ap3]] – RrMO (mutant) + FAD + NADP <br />
-
*Cyclohexanone monooxygenase
+
*'''Cyclohexanone monooxygenase'''
**[[5m10]] – TmMO + FAD + NAP + nicotinamide – ''Thermocripsum municipale''<br />
**[[5m10]] – TmMO + FAD + NAP + nicotinamide – ''Thermocripsum municipale''<br />
Line 193: Line 211:
**[[3ucl]] – RhMO + FAD + NADP + cyclohexanone <br />
**[[3ucl]] – RhMO + FAD + NADP + cyclohexanone <br />
-
*Lysine 6-monooxygenase
+
*'''Lysine 6-monooxygenase'''
**[[5cqf]] – MO – ''Pseudomonas syringae''<br />
**[[5cqf]] – MO – ''Pseudomonas syringae''<br />
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**[[5o8r]] – EaMO + FAD + NADP <br />
**[[5o8r]] – EaMO + FAD + NADP <br />
-
*EDTA monooxygenase
+
*'''EDTA monooxygenase'''
**[[5dqp]] – MO – ''Chelativorans''<br />
**[[5dqp]] – MO – ''Chelativorans''<br />
-
*Rifampicin monooxygenase or Pentachlorophenol 4-monooxygenase
+
*'''Rifampicin monooxygenase or Pentachlorophenol 4-monooxygenase'''
**[[5vqb]] – SvMO + FAD – ''Sterptomyces venezuelae''<br />
**[[5vqb]] – SvMO + FAD – ''Sterptomyces venezuelae''<br />
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**[[5kox]] – NfMO + FAD + rifampicin <br />
**[[5kox]] – NfMO + FAD + rifampicin <br />
-
*3,6-diketocamphane 1,6 monooxygenase
+
*'''3,6-diketocamphane 1,6 monooxygenase'''
**[[5aec]] – PpMO <br />
**[[5aec]] – PpMO <br />
**[[4uwm]] – PpMO + FMN<br />
**[[4uwm]] – PpMO + FMN<br />
-
*Lytic polysaccharide monooxygenase
+
*'''4-hydroxybenzoate 3 monooxygenase'''
 +
 
 +
**[[6ju1]] – PaMO (mutant) + dihydroxybenzoate<br />
 +
 
 +
*'''FAD monooxygenase'''
 +
 
 +
**[[6pvg]] – PfMO + FAD – ''Penicillium fellutamanum''<br />
 +
**[[6pvf]], [[6pvj]] – PfMO + FAD + malbrancheamide <br />
 +
**[[6pvh]]. [[6pvi]] – PfMO + FAD + paraherquamide <br />
 +
 
 +
*'''Lytic polysaccharide monooxygenase''' or '''LPMO'''
**[[5tki]], [[5foh]], [[4qi8]] – NcMO-2 + Cu – ''Neurospora crassa''''Italic text''<br />
**[[5tki]], [[5foh]], [[4qi8]] – NcMO-2 + Cu – ''Neurospora crassa''''Italic text''<br />
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**[[4mah]] – moMO + Zn<br />
**[[4mah]] – moMO + Zn<br />
**[[5no7]] – MO – ''Pycnoporus cinnabarinus''<br />
**[[5no7]] – MO – ''Pycnoporus cinnabarinus''<br />
 +
**[[6ndq]] – MO – ''Kitsatospora papulosa''<br />
 +
**[[6ydc]], [[6ydd]], [[6yde]], [[6ydf]] – MO + Cu – ''Collariella virescens<''br />
 +
**[[7a8v]] – MO + Cu – ''Talaromyces verruculosus<''br />
 +
**[[5lsv]], [[5t7j]], [[5t7k]], [[5t7n]], [[6tbr]], [[6tc4]] – AoMO + Zn – ''Aspergillus oryxae''<br />
 +
**[[6tbq]] – AoMO + Zn + Cu<br />
 +
**[[6z5y]] – MO + Cu – ''Phytophthora infestans<''br />
 +
**[[6t5z]] – MO + Cu – ''Photorhabdus laumondii''<br />
 +
**[[5opf]] – MO + Cu – ''Micromonospora aurantiaca''<br />
 +
**[[5fjq]] – MO + Cu – ''Cellvibrio japonicus''<br />
 +
**[[7ntl]] – MO + Cu – fungus<br />
 +
**[[6if7]] – MO – fern<br />
 +
**[[5msz]] – MO + Cu – firebrat<br />
 +
**[[5o2w]] – MO + Cu – ''Trichoderma reesei''<br />
 +
**[[5l2v]] – MO + Cu – ''Listeria monocytogenes''<br />
-
*Peptidyl-glycine alpha-amidating monooxygenase
+
*'''Peptidyl-glycine alpha-amidating monooxygenase'''
**[[5mw0]], [[5wkw]] – rMO <br />
**[[5mw0]], [[5wkw]] – rMO <br />
**[[1yjl]] – rMO (mutant)<br />
**[[1yjl]] – rMO (mutant)<br />
**[[3mib]], [[3mic]], [[3mid]], [[3mie]], [[3mif]], [[3mig]], [[3mih]], [[3mlj]], [[3mlk]], [[3mll]], [[1opm]] – rMO + Cu + Ni <br />
**[[3mib]], [[3mic]], [[3mid]], [[3mie]], [[3mif]], [[3mig]], [[3mih]], [[3mlj]], [[3mlk]], [[3mll]], [[1opm]] – rMO + Cu + Ni <br />
-
**[[6ao6]], [[5wja]] – rMO (mutant) + Cu + Ni<br />
+
**[[6ao6]], [[5wja]], [[6nck]] – rMO (mutant) + Cu + Ni<br />
**[[1sdw]] – rMO + Cu + Ni + O2 + threonine derivative<br />
**[[1sdw]] – rMO + Cu + Ni + O2 + threonine derivative<br />
**[[1yjk]], [[1yip]], [[1phm]] – rMO + Cu<br />
**[[1yjk]], [[1yip]], [[1phm]] – rMO + Cu<br />
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**[[3fvz]] – rMO + Zn + Fe<br />
**[[3fvz]] – rMO + Zn + Fe<br />
-
*Antibiotic biosynthesis monooxygenase
+
*'''Antibiotic biosynthesis monooxygenase'''
**[[4hl9]] – MO – ''Rhodospirillum rubrum''<br />
**[[4hl9]] – MO – ''Rhodospirillum rubrum''<br />
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**[[2ril]] – MO – ''Shewanella loihica''<br />
**[[2ril]] – MO – ''Shewanella loihica''<br />
-
*Monooxygenase
+
*'''Monooxygenase'''
**[[2i7g]] – MO – ''Agrobacterium tumefaciens''<br />
**[[2i7g]] – MO – ''Agrobacterium tumefaciens''<br />
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**[[5f5n]] – MiMO + NAD + substrate <br />
**[[5f5n]] – MiMO + NAD + substrate <br />
-
*Monooxygenase TROPB
+
*'''Monooxygenase TROPB'''
**[[6nes]] – TsMO + FAD – ''Talaromyces stipitatus''<br />
**[[6nes]] – TsMO + FAD – ''Talaromyces stipitatus''<br />
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**[[6net]] – TsMO + FAD + dihydroxy dimethylbenzaldehyde<br />
**[[6net]] – TsMO + FAD + dihydroxy dimethylbenzaldehyde<br />
-
*Lactate 2-monooxygenase or lactate oxydase
+
*'''Lactate 2-monooxygenase or lactate oxydase'''
**[[6dvi]] – MsLMO + FMN – ''Mycobacterium smegmatis''<br />
**[[6dvi]] – MsLMO + FMN – ''Mycobacterium smegmatis''<br />
**[[6dvh]] – MsLMO (mutant) + FMN <br />
**[[6dvh]] – MsLMO (mutant) + FMN <br />
 +
**[[4rje]] – AvLMO – ''Aerococcus viridans'' <br />
 +
**[[2du2]], [[2e77]], [[2zfa]] – AvLMO + FMN <br />
 +
**[[2nli]] – AvLMO + FMN + lactate<br />
-
*Squalene monooxygenase or squalene epoxidase
+
*'''Dimethyl-sulfide monooxygenase'''
-
**[[6c6r]], [[6c6p]], [[6c6n]] – hSMO + FAD + inhibitor<br />
+
**[[6ak1]] – DMOA – ''Hyphomicrobium sulfonivorans''<br />
-
*Dimethyl-sulfide monooxygenase
+
*'''TetX monooxygenase''' or Flavin-dependent monooxygenase
-
**[[6ak1]] – DMOA – ''Hyphomicrobium sulfonivorans''<br />
+
**[[2xdo]], [[2xyo]] – BtTetX2 – ''Bacterioides thetaiotaomicron''<br />
 +
**[[2y6q]], [[2y6r]] – BtTetX2 + tetracycline derivative <br />
 +
**[[7epv]] – EcTetX4 <br />
 +
**[[7epw]] – EcTetX4 + tetracycline derivative <br />
 +
**[[8er1]] – CoTetX6 – Chryseobacterium oncorhynchi <br />
 +
**[[8er0]] – ECoetX6 + tetracycline derivative <br />
-
*Salicylate 1-monooxygenase or salicylate hydroxylase See [[Hydroxylase]]
+
'''Salicylate 1-monooxygenase''' or salicylate hydroxylase See [[Hydroxylase]]
'''Methane monooxygenase''' See [[Methane monooxygenase]]
'''Methane monooxygenase''' See [[Methane monooxygenase]]
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'''Luciferin 4-monooxygenase and Alkanal monooxygenase''' See [[Luciferase]]
'''Luciferin 4-monooxygenase and Alkanal monooxygenase''' See [[Luciferase]]
 +
 +
'''Phenylalanine 4-monooxygenase''' or phenylalanine-4-hydroxylase See [[Hydroxylase]]
 +
 +
'''Squalene monooxygenase''' or squalene epoxidase See [[Epoxidase]]
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of monooxygenase

Updated on 19-June-2024

Salicylate 1-monooxygenase or salicylate hydroxylase See Hydroxylase

Methane monooxygenase See Methane monooxygenase

Camphor 5-monooxygenase See Cytochrome P450

Luciferin 4-monooxygenase and Alkanal monooxygenase See Luciferase

Phenylalanine 4-monooxygenase or phenylalanine-4-hydroxylase See Hydroxylase

Squalene monooxygenase or squalene epoxidase See Epoxidase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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