Ficolin

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{{STRUCTURE_2j64| PDB=2j64 | SIZE=400| SCENE= |right|CAPTION=Human H-ficolin binding domain trimer complex with Ca+2 ion, [[2j64]] }}
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<StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '>
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'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.
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== Function ==
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'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''.
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*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>.
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== Disease ==
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Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>.
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== Structural highlights ==
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<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>.
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<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres.
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</StructureSection>
== 3D Structures of Ficolin ==
== 3D Structures of Ficolin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===H-ficolin===
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*H-ficolin
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[[2j64]] - hH-Fic binding domain - human<br />
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[[2j5z]] - hH-Fic binding domain + galactose<br />
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[[2j60]] - hH-Fic binding domain + fucose<br />
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[[2j61]] - hH-Fic binding domain + acetyl-glucosamine<br />
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===L-ficolin===
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**[[2j64]] - hH-Fic binding domain - human<br />
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**[[2j5z]] - hH-Fic binding domain + galactose<br />
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**[[2j60]] - hH-Fic binding domain + fucose<br />
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**[[2j61]] - hH-Fic binding domain + acetyl-glucosamine<br />
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[[2j3g]] - hL-Fic binding domain<br />
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*L-ficolin
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[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br />
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[[2j0h]] - hL-Fic binding domain + acetylcholine<br />
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[[2j0y]] - hL-Fic binding domain + glucan<br />
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[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br />
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[[2j3f]] - hL-Fic binding domain + galactosamine<br />
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[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br />
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[[2j3u]] - hL-Fic binding domain + galactose<br />
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===M-ficolin===
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**[[2j3g]], [[4r9t]] - hL-Fic binding domain<br />
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**[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br />
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**[[2j0h]] - hL-Fic binding domain + acetylcholine<br />
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**[[4nyt]] - hL-Fic binding domain + phosphocholine<br />
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**[[2j0y]] - hL-Fic binding domain + glucan<br />
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**[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br />
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**[[2j3f]] - hL-Fic binding domain + galactosamine<br />
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**[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br />
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**[[4r9j]] - hL-Fic binding domain + glucosamine sulfate<br />
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**[[2j3u]] - hL-Fic binding domain + galactose<br />
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[[2d39]] – hM-Fic fibrinogen-like domain<br />
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*M-ficolin
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[[2wnp]] - hM-Fic fibrinogen-like domain (mutant) <br />
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[[2jhh]], [[2jhm]] – hM-Fic C terminal<br />
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[[2jhi]] - hL-Mic C terminal + acetyl-galactosamine<br />
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[[2jhk]] - hL-Mic C terminal + acetyl-glucosamine<br />
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[[2jhl]] - hL-Mic C terminal + sialic acid
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**[[2d39]] – hM-Fic fibrinogen-like domain<br />
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**[[2wnp]] - hM-Fic fibrinogen-like domain (mutant) <br />
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**[[2jhh]], [[2jhm]] – hM-Fic C terminal<br />
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**[[2jhi]] - hL-Mic C terminal + acetyl-galactosamine<br />
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**[[2jhk]] - hL-Mic C terminal + acetyl-glucosamine<br />
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**[[2jhl]] - hL-Mic C terminal + sialic acid
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}}
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== References ==
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<references/>

Current revision

Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64)

Drag the structure with the mouse to rotate

3D Structures of Ficolin

Updated on 23-June-2024


References

  1. ↑ Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:http://dx.doi.org/10.1016/S0171-2985(98)80026-0
  2. ↑ Honoré C, Rørvig S, Munthe-Fog L, Hummelshøj T, Madsen HO, Borregaard N, Garred P. The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma. Mol Immunol. 2008 May;45(10):2782-9. PMID:18343499 doi:10.1016/j.molimm.2008.02.005
  3. ↑ Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118
  4. ↑ Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869

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Michal Harel, Alexander Berchansky

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