Glycoproteins B and D
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 6: | Line 6: | ||
'''Glycoproteins B, D''' (gB, gD) are components of the cell-entry complex of herpes viruses<ref>PMID:16840698</ref><ref>PMID:21980294</ref>. | '''Glycoproteins B, D''' (gB, gD) are components of the cell-entry complex of herpes viruses<ref>PMID:16840698</ref><ref>PMID:21980294</ref>. | ||
| + | *'''Glycoprotein B''' is required after herpes simplex virus attachment but before the expression of viral proteins<ref>PMID:2839688</ref>. | ||
| + | *'''Glycoprotein D''' determines which cells can be infected by herpes simplex virus by binding to the cell receptors which mediate the viral entry<ref>PMID:15273289</ref>. | ||
| Line 23: | Line 25: | ||
**[[2gum]], [[4bom]] - Hhv1gB extracellular domain<br /> | **[[2gum]], [[4bom]] - Hhv1gB extracellular domain<br /> | ||
**[[3nw8]], [[3nwa]], [[3nwd]], [[3nwf]], [[4hsi]], [[4l1r]] – Hhv1gB extracellular domain 30-730 (mutant) <br /> | **[[3nw8]], [[3nwa]], [[3nwd]], [[3nwf]], [[4hsi]], [[4l1r]] – Hhv1gB extracellular domain 30-730 (mutant) <br /> | ||
| + | **[[7uhz]], [[7ui0]] – Hhv1gB + antibody – Human alphaherpesvirus 1 – Cryo EM<br /> | ||
**[[6vn1]] – Hhv3gB + antibody – Human alphaherpesvirus 3 – Cryo EM<br /> | **[[6vn1]] – Hhv3gB + antibody – Human alphaherpesvirus 3 – Cryo EM<br /> | ||
**[[7k1s]] – Hhv3gB – Cryo EM<br /> | **[[7k1s]] – Hhv3gB – Cryo EM<br /> | ||
| Line 36: | Line 39: | ||
**[[4ot1]], [[5c6t]] – hCVgB + antibody<br /> | **[[4ot1]], [[5c6t]] – hCVgB + antibody<br /> | ||
**[[6vlk]] – gB – varicella-zoster virus<br /> | **[[6vlk]] – gB – varicella-zoster virus<br /> | ||
| + | **[[3fvc]] – EbvgB – Epstein-Barr virus <br /> | ||
| + | **[[7fbi]] – EbvgB + antibody - Cryo EM<br /> | ||
*Glycoprotein D | *Glycoprotein D | ||
Current revision
| |||||||||||
3D Structures of Glycoproteins B and D
Updated on 01-July-2024
References
- ↑ Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC. Crystal structure of glycoprotein B from herpes simplex virus 1. Science. 2006 Jul 14;313(5784):217-20. PMID:16840698 doi:313/5784/217
- ↑ Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A. Structure of herpes simplex virus glycoprotein d bound to the human receptor nectin-1. PLoS Pathog. 2011 Sep;7(9):e1002277. Epub 2011 Sep 29. PMID:21980294 doi:10.1371/journal.ppat.1002277
- ↑ Cai WH, Gu B, Person S. Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. J Virol. 1988 Aug;62(8):2596-604. PMID:2839688 doi:10.1128/JVI.62.8.2596-2604.1988
- ↑ Manoj S, Jogger CR, Myscofski D, Yoon M, Spear PG. Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12414-21. PMID:15273289 doi:10.1073/pnas.0404211101
