Intercellular adhesion molecule

From Proteopedia

Revision as of 07:34, 4 July 2024

spinqualitylabelsall models Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Intercellular adhesion molecule (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation[1]. ICAM contains 5 Ig-like domains. ICAM-1 is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system. ICAM-2 mediates adhesive interactions important for antigen-specific immune response. Disease ICAM mutation is involved in multiple sclerosis[2].

3D structures of intercellular adhesion molecule

Updated on 04-July-2024

References

1. ↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
2. ↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979