Intercellular adhesion molecule

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<StructureSection load='1mq8' size='340' side='right' caption='Structure of human ICAM-1 domains 1-2 (grey and pink) complex with LFA-1 (yellow and green) and Mg+2 ion (green) (PDB code [[1mq8]]).' scene=''>
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<StructureSection load='1mq8' size='340' side='right' caption='Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code [[1mq8]]).' scene=''>
== Function ==
== Function ==
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'''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily. ICAM binds to LFA-1 and macrophage-1 antigen during inflammation. ICAM contains 5 Ig-like domains.
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'''Intercellular adhesion molecule''' (ICAM) is part of the immunoglobulin superfamily. ICAM binds to leukocyte function associated molecule 1 (LFA-1) and macrophage-1 antigen during inflammation<ref>PMID:8834767</ref>. ICAM contains 5 Ig-like domains.
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*'''ICAM-1''' is Ig-like cell adhesion molecule which has a role in inflammatory processes and in T-cell mediated host defines system.
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*'''ICAM-2''' mediates adhesive interactions important for antigen-specific immune response.
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*'''ICAM-3''' acts as recognition receptor in the phagocytosis of macrophages in engulfment of apoptotic neutrophils<ref>PMID:23775590</ref>.
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*'''ICAM-5''' has 2 types of binding activities: binding between neutrons and binding between neuron and leukocytes.
== Disease ==
== Disease ==
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ICAM mutation is involved in multiple sclerosis<ref>PMID:12590979</ref>.
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== Relevance ==
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</StructureSection>
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== Structural highlights ==
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==3D structures of intercellular adhesion molecule==
==3D structures of intercellular adhesion molecule==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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===ICAM-1 (CD54)===
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*ICAM-1 (CD54)
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[[1iam]], [[1ic1]], [[1d3l]] – hICAM N terminal domain – human<br />
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[[1p53]] – hICAM domain 3-5<br />
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''ICAM-1 complexes''
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**[[1iam]], [[1ic1]], [[1d3l]] – hICAM N terminal domain – human<br />
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**[[1p53]] – hICAM domain 3-5<br />
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[[1d3e]], [[1d3i]] – hICAM N terminal domain + rhinovirus coat proteins - CryoEM<br />
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*ICAM-1 complexes
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[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
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[[3tcx]] – hICAM domain 1 + LFA-1<br />
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[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
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[[2qz4]] – hICAM domain 4 + antibody<br />
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===ICAM-2===
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**[[1d3e]], [[1d3i]] – hICAM N terminal domain + rhinovirus coat proteins - CryoEM<br />
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**[[7bg7]] – hICAM + rhinovirus polyproteins - CryoEM<br />
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**[[1mq8]] – hICAM domain 1-2 + LFA-1<br />
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**[[3tcx]] – hICAM domain 1 + LFA-1<br />
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**[[6eit]] – hICAM domain 1-2 + coxsakievirus coat proteins - CryoEM<br />
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**[[1z7z]] – hICAM domain 1-5 + coxsakievirus coat proteins - CryoEM<br />
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**[[2oz4]] – hICAM domain 4 + antibody<br />
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**[[5mza]], [[6s8u]] – hICAM residues 28-212 + erythrocyte membrane protein 1<br />
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[[1zxq]] – hICAM extracellular domain <br />
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*ICAM-2
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===ICAM-3===
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**[[1zxq]] – hICAM extracellular domain <br />
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[[1t0p]] – hICAM N terminal domain + LFA-1<br />
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*ICAM-3
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===ICAM-5===
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**[[1t0p]] – hICAM N terminal domain + LFA-1<br />
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[[3bn3]] – hICAM N terminal domain + LFA-1<br />
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*ICAM-5
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**[[3bn3]] – hICAM N terminal domain + LFA-1<br />
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**[[4oi9]], [[4oia]], [[4oib]] – hICAM domain D1-D4<br />
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}}
== References ==
== References ==

Current revision

Structure of glycosylated human ICAM-1 domains 1-2 (grey) complex with LFA-1 (green) and Mg+2 ion (green) (PDB code 1mq8).

Drag the structure with the mouse to rotate

3D structures of intercellular adhesion molecule

Updated on 04-July-2024

References

  1. ↑ van de Stolpe A, van der Saag PT. Intercellular adhesion molecule-1. J Mol Med (Berl). 1996 Jan;74(1):13-33. PMID:8834767
  2. ↑ Kristóf E, Zahuczky G, Katona K, Doró Z, Nagy É, Fésüs L. Novel role of ICAM3 and LFA-1 in the clearance of apoptotic neutrophils by human macrophages. Apoptosis. 2013 Oct;18(10):1235-51. PMID:23775590 doi:10.1007/s10495-013-0873-z
  3. ↑ Nejentsev S, Laaksonen M, Tienari PJ, Fernandez O, Cordell H, Ruutiainen J, Wikstrom J, Pastinen T, Kuokkanen S, Hillert J, Ilonen J. Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. Hum Immunol. 2003 Mar;64(3):345-9. PMID:12590979

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Michal Harel

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