Latrophilin

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== Function ==
== Function ==
'''Latrophilin''' (LAT) or '''adhesion G protein-coupled receptor''' is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates<ref>PMID:21618826</ref>. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter.
'''Latrophilin''' (LAT) or '''adhesion G protein-coupled receptor''' is the major brain receptor for α-latroxin - a black widow spidertoxin which stimulates strong neuronal exocytosis in vertebrates<ref>PMID:21618826</ref>. LAT is cleaved proteolitically into 2 fragments which reassociate upon binding an agonist and upon reassociation cause release of calcium from intracellular stores and massive release of neurotransmitter.
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*Latrophilin-3" mediates synapse formation in the hypoccampus<ref>PMID:38233523</ref>.
== Disease ==
== Disease ==

Revision as of 08:13, 10 July 2024

Human latrophilin-3 olfactomedin domain (magenta) complex with leucine-rich repeat transmembrane protein 3 (blue) and Ca+2 ion (green) (PDB code 5cmn)

Drag the structure with the mouse to rotate

3D structures of latrophilin

Updated on 10-July-2024

References

  1. ↑ Silva JP, Ushkaryov YA. The latrophilins, "split-personality" receptors. Adv Exp Med Biol. 2010;706:59-75. PMID:21618826
  2. ↑ Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Südhof TC. Alternative splicing of latrophilin-3 controls synapse formation. Nature. 2024 Feb;626(7997):128-135. PMID:38233523 doi:10.1038/s41586-023-06913-9
  3. ↑ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domene S, Velez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. doi: 10.1038/mp.2010.6. Epub 2010 Feb, 16. PMID:20157310 doi:http://dx.doi.org/10.1038/mp.2010.6
  4. ↑ Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Sudhof TC, Arac D. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure. 2015 Jul 28. pii: S0969-2126(15)00277-4. doi:, 10.1016/j.str.2015.06.024. PMID:26235030 doi:http://dx.doi.org/10.1016/j.str.2015.06.024

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