Netrin receptor
From Proteopedia
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<StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | <StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>. | + | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. |
| + | *Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> . | ||
== Disease == | == Disease == | ||
Revision as of 10:11, 16 July 2024
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3D Structures of netrin receptor
Updated on 16-July-2024
References
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Keleman K, Dickson BJ. Short Neuron. 2001 Nov 20;32(4):605-17. PMID:11719202 doi:10.1016/s0896-6273(01)00505-0
- ↑ Mehlen P, Llambi F. Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer. 2005 Jul 11;93(1):1-6. PMID:15956977 doi:http://dx.doi.org/10.1038/sj.bjc.6602656
