Netrin receptor

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*Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> .
*Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> .
*'''UNC-5B receptor''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>.
*'''UNC-5B receptor''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>.
 +
*'''UNC-5D receptor''' may mediate the effect of netrin-4 on cortical cell survival<ref>PMID:21216843</ref>.
== Disease ==
== Disease ==

Revision as of 10:19, 16 July 2024

Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code 4urt)

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3D Structures of netrin receptor

Updated on 16-July-2024

References

  1. ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
  2. ↑ Keleman K, Dickson BJ. Short Neuron. 2001 Nov 20;32(4):605-17. PMID:11719202 doi:10.1016/s0896-6273(01)00505-0
  3. ↑ Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86. PMID:15510105 doi:10.1038/nature03080
  4. ↑ Takemoto M, Hattori Y, Zhao H, Sato H, Tamada A, Sasaki S, Nakajima K, Yamamoto N. Laminar and areal expression of unc5d and its role in cortical cell survival. Cereb Cortex. 2011 Aug;21(8):1925-34. PMID:21216843 doi:10.1093/cercor/bhq265
  5. ↑ Mehlen P, Llambi F. Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer. 2005 Jul 11;93(1):1-6. PMID:15956977 doi:http://dx.doi.org/10.1038/sj.bjc.6602656

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Michal Harel

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