Netrin receptor
From Proteopedia
(Difference between revisions)
| (8 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
<StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | <StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | ||
== Function == | == Function == | ||
| - | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>. | + | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. |
| + | *Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> . | ||
| + | *'''UNC-5B receptor''' or '''UNC-5H2''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>. | ||
| + | *'''UNC-5D receptor''' may mediate the effect of netrin-4 on cortical cell survival<ref>PMID:21216843</ref>. | ||
== Disease == | == Disease == | ||
| Line 16: | Line 19: | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *Netrin receptor DCC | + | *Netrin receptor DCC; domains – ectodomain 25-374; FN1 419-524; FN2 528-620; FN3 602-718; FN4 716-818; FN5 833-942; FN6 944-1044; P3 1390-1447. |
**[[2ed7]] – hDCC first fibronectin type III domain – human - NMR<BR /> | **[[2ed7]] – hDCC first fibronectin type III domain – human - NMR<BR /> | ||
| Line 25: | Line 28: | ||
**[[2ede]] – hDCC sixth fibronectin type III domain - NMR<BR /> | **[[2ede]] – hDCC sixth fibronectin type III domain - NMR<BR /> | ||
**[[3au4]] – hDCC P3 motif + myosin-X <BR /> | **[[3au4]] – hDCC P3 motif + myosin-X <BR /> | ||
| + | **[[6bz3]] – hDCC P3 motif + focal adhesion kinase FAT domain <BR /> | ||
**[[4urt]] – hDCC fibronectin type V-VI domains + neutrin-1 <BR /> | **[[4urt]] – hDCC fibronectin type V-VI domains + neutrin-1 <BR /> | ||
| + | **[[5x83]] – hDCC fibronectin 4-6 domains <BR /> | ||
**[[4plo]] – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse<BR /> | **[[4plo]] – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse<BR /> | ||
**[[3pzd]] – mDCC P3 motif + myosin-X <BR /> | **[[3pzd]] – mDCC P3 motif + myosin-X <BR /> | ||
**[[3laf]] – rDCC residues 39-421 - rat<BR /> | **[[3laf]] – rDCC residues 39-421 - rat<BR /> | ||
| + | **[[5z5k]] – rDCC residues 39-421 + draxin peptide <BR /> | ||
| + | |||
| + | *Netrin receptor UNC5 | ||
| + | |||
| + | **[[8edc]] – `CeUNC5D Ig1+Ig2 domains 29-228 – ''Caenorhabditis elegans''<BR /> | ||
| + | **[[8edi]] – `CeUNC5D Ig1+Ig2 domains + heparin<BR /> | ||
*Netrin receptor UNC5A | *Netrin receptor UNC5A | ||
| Line 34: | Line 45: | ||
**[[4v2a]] – hUNC5A ectodomain <BR /> | **[[4v2a]] – hUNC5A ectodomain <BR /> | ||
| - | *Netrin receptor UNC5B | + | *Netrin receptor UNC5B or UNC5H2 |
| - | **[[3g5b]] – rUNC5B cytoplasmic domain (mutant)<BR /> | + | **[[6ool]] – mUNC5B ectodomain<BR /> |
| + | **[[1wmg]] – mUNC5B death domain <BR /> | ||
| + | **[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | ||
*Netrin receptor UNC5D | *Netrin receptor UNC5D | ||
| Line 42: | Line 55: | ||
**[[4v2b]] – rUNC5D Ig1 domain <BR /> | **[[4v2b]] – rUNC5D Ig1 domain <BR /> | ||
**[[4v2c]] – rUNC5D Ig1 domain + FLRT2 LRR domain<BR /> | **[[4v2c]] – rUNC5D Ig1 domain + FLRT2 LRR domain<BR /> | ||
| + | **[[7za1]], [[7za2]], [[7za3]] – rUNC5D residues 46-307 + glypican-3<BR /> | ||
**[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | **[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | ||
| - | *Netrin receptor UNC5H2 | ||
| - | |||
| - | **[[1wmg]] – mUNC5H2 death domain <BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
3D Structures of netrin receptor
Updated on 16-July-2024
References
- ↑ Moore SW, Tessier-Lavigne M, Kennedy TE. Netrins and their receptors. Adv Exp Med Biol. 2007;621:17-31. doi: 10.1007/978-0-387-76715-4_2. PMID:18269208 doi:http://dx.doi.org/10.1007/978-0-387-76715-4_2
- ↑ Keleman K, Dickson BJ. Short Neuron. 2001 Nov 20;32(4):605-17. PMID:11719202 doi:10.1016/s0896-6273(01)00505-0
- ↑ Lu X, Le Noble F, Yuan L, Jiang Q, De Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004 Nov 11;432(7014):179-86. PMID:15510105 doi:10.1038/nature03080
- ↑ Takemoto M, Hattori Y, Zhao H, Sato H, Tamada A, Sasaki S, Nakajima K, Yamamoto N. Laminar and areal expression of unc5d and its role in cortical cell survival. Cereb Cortex. 2011 Aug;21(8):1925-34. PMID:21216843 doi:10.1093/cercor/bhq265
- ↑ Mehlen P, Llambi F. Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. Br J Cancer. 2005 Jul 11;93(1):1-6. PMID:15956977 doi:http://dx.doi.org/10.1038/sj.bjc.6602656
