Nuclear receptor coactivator
From Proteopedia
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| - | + | <StructureSection load='' size='350' side='right' scene='49/494427/Cv/1' caption='Mouse nuclear receptor activator (green) complex with STAT6 transactivator domain LXXLL peptide (sky blue) and I-1 ions, [[1oj5]]'> | |
'''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br /> | '''Nuclear receptor coactivator''' (NCOA) is a protein recruited by nuclear receptors in order to enhance or repress DNA transcription. NCOA is involved in coactivation with transcription factors<ref>PMID:9121485</ref>.<br /> | ||
*'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br /> | *'''NCOA1''' shows histone acetyltransferase activity and is required for steroid hormone response.<br /> | ||
*'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br /> | *'''NCOA2''' is a DNA transcription coactivator with glucocorticoid receptor.<br /> | ||
| - | *'''NCOA3''' shows histone acetyltransferase activity. | + | *'''NCOA3''' shows histone acetyltransferase activity.<br /> |
| + | *'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | ||
| + | *'''NCOA7''' may be a driver for beast cancer metastasis<ref>PMID:38699661</ref><br /> | ||
| + | See also: [[Glucocorticoids]] and [[Steroid Hormones and their receptors]].<br />. | ||
| + | == Structural highlights == | ||
| + | *<scene name='49/494427/Cv/7'>NCOA/STAT6 transactivator domain LXXLL peptide interactions</scene>. | ||
| + | *<scene name='49/494427/Cv/8'>1st Iod coordination site</scene>. | ||
| + | *<scene name='49/494427/Cv/9'>2nd Iod coordination site</scene>. Water molecules are shown as red spheres. | ||
| + | *<scene name='49/494427/Cv/10'>3th and 4th Iod coordination sites</scene>. | ||
| + | *<scene name='49/494427/Cv/11'>5th Iod coordination site</scene>. | ||
| + | </StructureSection> | ||
==3D structures of nuclear receptor coactivator== | ==3D structures of nuclear receptor coactivator== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[ | + | [[2c52]] – hNCOA1 residues 920-970 + CREB-binding protein – human<br /> |
| - | [[1kbh]] – | + | [[1kbh]], [[6es7]], [[6sqc]] – hNCOA3 1040-1086 + CREB-binding protein – NMR<br /> |
| - | [[ | + | [[1v95]] – hNCOA5 anticodon binding domain 197-313 – human – NMR<br /> |
| - | [[1oj5]] – | + | [[8arp]] – hNCOA7 781-942 <br /> |
| + | [[1oj5]] – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse<br /> | ||
| + | [[5y7w]] - mNCOA1A Pas-B domain + YL-2 peptide<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of nuclear receptor coactivator
Updated on 17-July-2024
2c52 – hNCOA1 residues 920-970 + CREB-binding protein – human
1kbh, 6es7, 6sqc – hNCOA3 1040-1086 + CREB-binding protein – NMR
1v95 – hNCOA5 anticodon binding domain 197-313 – human – NMR
8arp – hNCOA7 781-942
1oj5 – mNCOA1A Pas-B domain 257-367 + signal transducer and activator of transcription peptide – mouse
5y7w - mNCOA1A Pas-B domain + YL-2 peptide
References
- ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
- ↑ Peng Z, Li Y, Xia S, Dai Q, Yin L, Chen M, Yang W, Shao G, Lin Q. Expression of nuclear receptor co‑activator 7 protein is associated with poor prognosis of breast cancer. Oncol Lett. 2024 Apr 23;27(6):278. PMID:38699661 doi:10.3892/ol.2024.14411
