1svc

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[[Image:1svc.gif|left|200px]]
[[Image:1svc.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1svc |SIZE=350|CAPTION= <scene name='initialview01'>1svc</scene>, resolution 2.600&Aring;
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The line below this paragraph, containing "STRUCTURE_1svc", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1svc| PDB=1svc | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1svc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1svc OCA], [http://www.ebi.ac.uk/pdbsum/1svc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1svc RCSB]</span>
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}}
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'''NFKB P50 HOMODIMER BOUND TO DNA'''
'''NFKB P50 HOMODIMER BOUND TO DNA'''
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[[Category: Harrison, S C.]]
[[Category: Harrison, S C.]]
[[Category: Mueller, C W.]]
[[Category: Mueller, C W.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: dna]]
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[[Category: Dna]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: nuclear protein]]
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[[Category: Nuclear protein]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: repeat]]
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[[Category: Repeat]]
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[[Category: transcription regulation]]
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[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 09:10:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:47:25 2008''
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Revision as of 06:10, 3 May 2008

Image:1svc.gif

Template:STRUCTURE 1svc

NFKB P50 HOMODIMER BOUND TO DNA


Overview

The structure of a large fragment of the p50 subunit of the human transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-kappa B interaction. The folds of these domains are related to immunoglobulin-like modules. The amino-terminal domain also resembles the core domain of p53.

About this Structure

1SVC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the NF-kappa B p50 homodimer bound to DNA., Muller CW, Rey FA, Sodeoka M, Verdine GL, Harrison SC, Nature. 1995 Jan 26;373(6512):311-7. PMID:7830764 Page seeded by OCA on Sat May 3 09:10:33 2008

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