9fst
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 9fst is ON HOLD Authors: Maurits, E., Huber, E.M., Dekker, P.M., Wang, X., Heinemeyer, W., Florea, B.I., Groll, M., Overkleeft, H.S. Description: Y...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Yeast 20S proteasome with human beta1i (1-51) in complex with epoxyketone inhibitor LU-001i== | |
| - | + | <StructureSection load='9fst' size='340' side='right'caption='[[9fst]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[9fst]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9FST OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9FST FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1IF8:azanylidene-[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(1S)-2-cyclohexyl-1-[(2R,3S,6R,7S)-3-methanoyl-2,6-dimethyl-6,7-bis(oxidanyl)-1,4-oxazepan-7-yl]ethyl]amino]-1-oxidanylidene-hexan-2-yl]carbamoyl]-4,4-bis(fluoranyl)pyrrolidin-1-yl]-1-oxidanylidene-propan-2-yl]amino]-2-oxidanylidene-ethyl]imino-azanium'>A1IF8</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9fst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9fst OCA], [https://pdbe.org/9fst PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9fst RCSB], [https://www.ebi.ac.uk/pdbsum/9fst PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9fst ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Florea | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. |
| - | [[Category: Huber | + | __TOC__ |
| - | [[Category: Maurits | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae]] |
| + | [[Category: Dekker PM]] | ||
| + | [[Category: Florea BI]] | ||
| + | [[Category: Groll M]] | ||
| + | [[Category: Heinemeyer W]] | ||
| + | [[Category: Huber EM]] | ||
| + | [[Category: Maurits E]] | ||
| + | [[Category: Overkleeft HS]] | ||
| + | [[Category: Wang X]] | ||
Current revision
Yeast 20S proteasome with human beta1i (1-51) in complex with epoxyketone inhibitor LU-001i
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