Penicillopepsin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:56, 18 July 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_1ppm| PDB=1ppm | SIZE=400| SCENE= |right| CAPTION=Penicillopepsin complex with peptide analog, [[1ppm]] }}
+
<StructureSection load='1ppm' size='400' side='right' scene='49/493723/Cv/1' caption='Glycosylated penicillopepsin complex with peptide analog and sulfate, [[1ppm]]' pspeed='8'>
-
<!--
+
-
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+
-
Or use the four-green-boxes-button to insert scrollable text adjacent
+
-
to a Jmol applet. Check out the other buttons as well!
+
-
-->
+
-
'''Penicillopepsin''' (PP) is a proteinase with a broad spectrum of substrates. PP prefers hydrophobic residues at P1 and P1’ sites. PP causes clotting in milk and activates trypsinogen. PP is a member of the aspartic proteinase family. Its extended binding site cleft can bind at least 7 amino acids.
+
 +
== Function ==
 +
'''Penicillopepsin''' (PP) is a proteinase with a broad spectrum of substrates. PP prefers hydrophobic residues at P1 and P1’ sites. PP is a member of the aspartic proteinase family. Its extended binding site cleft can bind at least 7 amino acids<ref>PMID:1172664</ref>.
 +
 +
== Relevance ==
 +
PP causes clotting in milk and activates trypsinogen.
 +
 +
== Structural highlights ==
 +
*<scene name='49/493723/Cv/3'>Binding site</scene>.
 +
*<scene name='49/493723/Cv/4'>Binding site cleft</scene>.
 +
</StructureSection>
==3D structures of penicillopepsin==
==3D structures of penicillopepsin==
 +
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[3app]] – PjPP – ''Penicillium janthinellum''<br />
[[3app]] – PjPP – ''Penicillium janthinellum''<br />
[[1ppl]], [[1ppm]], [[1ppk]] – PjPP + peptide analog<br />
[[1ppl]], [[1ppm]], [[1ppk]] – PjPP + peptide analog<br />
[[1apt]], [[1apu]], [[1apv]], [[1apw]] - PjPP + pepstatin analog<br />
[[1apt]], [[1apu]], [[1apv]], [[1apw]] - PjPP + pepstatin analog<br />
-
[[2wea]], [[2web]], [[2wec]], [[2wed]], [[1bxo]], [[1bxq]] - PjPP + peptidyl inhibitor
+
[[2wea]], [[2web]], [[2wec]], [[2wed]], [[1bxo]], [[1bxq]] - PjPP + peptidyl inhibitor<br />
 +
== References ==
 +
<references/>
 +
[[Category:Topic Page]]

Current revision

Glycosylated penicillopepsin complex with peptide analog and sulfate, 1ppm

Drag the structure with the mouse to rotate

3D structures of penicillopepsin

Updated on 18-July-2024

3app – PjPP – Penicillium janthinellum
1ppl, 1ppm, 1ppk – PjPP + peptide analog
1apt, 1apu, 1apv, 1apw - PjPP + pepstatin analog
2wea, 2web, 2wec, 2wed, 1bxo, 1bxq - PjPP + peptidyl inhibitor

References

  1. ↑ Takahashi M, Hofmann T. Acyl intermediates in penicillopepsin-catalysed reactions and a discussion of the mechanism of action of pepsins. Biochem J. 1975 Jun;147(3):549-63. PMID:1172664

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Penicillopepsin"
Personal tools