Plasminogen activator

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**[[1bqy]] – PLA – Pit viper
**[[1bqy]] – PLA – Pit viper
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*Tissue plasminogen activator
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*Tissue plasminogen activator; Domains – fibrin-binding 36-85; kringle 1 69-153; kringle 2 209-298; catalytic 311-561
**[[1a5h]] – hTPA HC+LC + benzamidine – human<br />
**[[1a5h]] – hTPA HC+LC + benzamidine – human<br />
**[[1rtf]] - hTPA HC+LC<br />
**[[1rtf]] - hTPA HC+LC<br />
**[[1tpg]] – hTPA F1-G - NMR<br />
**[[1tpg]] – hTPA F1-G - NMR<br />
-
**[[1bda]] – hTPA catalytic domain (mutant) + EGR-CMK<br />
 
**[[1pk2]] – hTPA kringle 2 domain + 6-aminohexanoic acid – NMR<br />
**[[1pk2]] – hTPA kringle 2 domain + 6-aminohexanoic acid – NMR<br />
**[[1tpk]], [[1pml]] - hTPA kringle 2 domain<br />
**[[1tpk]], [[1pml]] - hTPA kringle 2 domain<br />
-
**[[1kdu]] - hTPA kringle domain – NMR<br />
+
**[[1kdu]] - hTPA kringle 1 domain – NMR<br />
**[[1tpm]], [[1tpn]] - hTPA fibrin-binding domain – NMR<br />
**[[1tpm]], [[1tpn]] - hTPA fibrin-binding domain – NMR<br />
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**[[5brr]] - hTPA catalytic domain (mutant) + plasminogen activator inhibitor 1<br />
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**[[1bda]] – hTPA catalytic domain (mutant) + EGR-CMK<br />
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**[[5brr]], [[5zlz]] - hTPA catalytic domain (mutant) + plasminogen activator inhibitor 1<br />
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*Urokinase-type plasminogen activator
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+
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**[[4xsk]] - hUPA catalytic domain (mutant) <br />
+
-
**[[5xg4]] - hUPA + quercetin<br />
+
-
**[[5lhs]] - mUPA catalytic domain - mouse<br />
+
-
**[[5lhn]], [[5lhp]], [[5lhq]], [[5lhr]], [[5hgg]] - mUPA catalytic domain (mutant) + antibody<br />
+
-
**[[4zks]], [[4zkn]], [[4zko]], [[4zkr]] - hUPA catalytic domain (mutant) + UPAIN-1-W3A<br />
+
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**[[4zhl]], [[4x1s]], [[4x1r]], [[4x1q]], [[4x1p]], [[4x1n]], [[4x0w]] - hUPA catalytic domain (mutant) + MUPAIN-1-IG<br />
+
-
**[[4zhm]] - hUPA catalytic domain (mutant) + MUPAIN-1-16-IG<br />
+
-
**[[4os7]], [[4os6]], [[4os5]], [[4os4]], [[4os2]], [[4os1]], [[4mny]], [[4mnx]], [[4mnw]], [[4mnv]] - hUPA catalytic domain (mutant) + bicyclic peptide<br />
+
*Coagulase/fibrinolysin
*Coagulase/fibrinolysin

Current revision

Human tissue plasminogen activator light chain catalytic domain (sky blue and green), heavy chain catalytic domain fragment (yellow and pink) complex with benzamidine, 1a5h

Drag the structure with the mouse to rotate

3D structures of plasminogen activator

Updated on 21-July-2024


References

  1. ↑ Sodeinde OA, Sample AK, Brubaker RR, Goguen JD. Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins. Infect Immun. 1988 Oct;56(10):2749-52. PMID:2843471
  2. ↑ . Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995 Dec 14;333(24):1581-7. PMID:7477192 doi:http://dx.doi.org/10.1056/NEJM199512143332401

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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