RNA uridylyltransferase
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'> | <StructureSection load='' size='350' side='right' caption='RNA uridylyltransferase-4 complex with UTP, UMP and Mg+2 ions (green) (PDB entry [[2q0f]])' scene='53/536705/Cv/1'> | ||
== Function == | == Function == | ||
| - | '''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' or '''TUTase''' (TUT) catalyzes the addition of uridine to RNA. TUT acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on TUT-4 see [[Terminal Uridylyl Transferase]]. | + | '''RNA uridylyltransferase''' or '''terminal uridylyltransferase''' or '''TUTase''' (TUT) catalyzes the addition of uridine to RNA. TUT acts as a suppressor of microRNA synthesis by mediating its terminal uridylation<ref>PMID:17189640</ref>. For additional details on TUT-4 see [[Terminal Uridylyl Transferase]]. |
| + | * ''Drosophila melanogaster'' TUTase is called '''TUTase Tailor'''. It is forming the uridylation-mediated processing complex which degrades a variety ofncRNAs in the cytoplasm <ref>PMID:26145174</ref>,.<ref>PMID:27729457</ref> | ||
== Structural highlights == | == Structural highlights == | ||
Current revision
| |||||||||||
3D Structures of RNA uridylyltransferase
Updated on 11-August-2024
References
- ↑ Stagno J, Aphasizheva I, Rosengarth A, Luecke H, Aphasizhev R. UTP-bound and Apo structures of a minimal RNA uridylyltransferase. J Mol Biol. 2007 Feb 23;366(3):882-99. Epub 2006 Dec 2. PMID:17189640 doi:10.1016/j.jmb.2006.11.065
- ↑ Bortolamiol-Becet D, Hu F, Jee D, Wen J, Okamura K, Lin CJ, Ameres SL, Lai EC. Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor. Mol Cell. 2015 Jul 16;59(2):217-28. doi: 10.1016/j.molcel.2015.05.034. Epub 2015 , Jul 2. PMID:26145174 doi:http://dx.doi.org/10.1016/j.molcel.2015.05.034
- ↑ Reimão-Pinto MM, Manzenreither RA, Burkard TR, Sledz P, Jinek M, Mechtler K, Ameres SL. Molecular basis for cytoplasmic RNA surveillance by uridylation-triggered decay in Drosophila. EMBO J. 2016 Nov 15;35(22):2417-2434. PMID:27729457 doi:10.15252/embj.201695164
- ↑ Stagno J, Aphasizheva I, Aphasizhev R, Luecke H. Dual role of the RNA substrate in selectivity and catalysis by terminal uridylyl transferases. Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14634-9. Epub 2007 Sep 4. PMID:17785418
