Single-stranded DNA-binding protein - Proteopedia, life in 3D

Current revision

References

↑ Marceau AH. Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repair. Methods Mol Biol. 2012;922:1-21. doi: 10.1007/978-1-62703-032-8_1. PMID:22976174 doi:http://dx.doi.org/10.1007/978-1-62703-032-8_1
↑ Ishibashi T, Kimura S, Furukawa T, Hatanaka M, Hashimoto J, Sakaguchi K. Two types of replication protein A 70 kDa subunit in rice, Oryza sativa: molecular cloning, characterization, and cellular & tissue distribution. Gene. 2001 Jul 11;272(1-2):335-43. PMID:11470540 doi:10.1016/s0378-1119(01)00555-8

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-[[Image:1eqq.png|left|200px|thumb|Crystal structure of SSB complex with ssDNA [[1eqq]]]]
-{{STRUCTURE_1eqq|  PDB=1eqq  | SIZE=350| SCENE= |right|CAPTION=SSB complex with ssDNA and UMP (stick model) [[1eqq]] }}
+<StructureSection load='1eqq' size='350' side='right' scene='' caption='E. coli SSB complex with ssDNA (stick model) and UMP [[1eqq]]'>
+'''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion.  SSB binds to DNA in a sequence-independent manner.  The binding of SSB enables processes like replication, DNA repair and recombination to occur.  SSB can form complexes with specific genome maintenance proteins helping their activities<ref>PMID:22976174</ref>.<br />
+*  '''Viral SSB proteins''' are monomeric.<br />
+*    '''Eukaryotic SSB''' ('''Replication protein A''' – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14.  RPA has 6 DNA-binding domains (DBD).<br />
+*'''Replication protein A70''' is the eukaryotic SSB 70kDa subunit<ref>PMID:11470540</ref>.
+*   '''Mitochondrial human SSB (HsmtSSB)''' is a homotetramer.
+See also [[Single stranded binding protein]].
-'''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion.  SSB binds to DNA in a sequence-independent manner.  The binding of SSB enables processes like replication, DNA repair and recombination to occur.  SSB can form complexes with specific genome maintenance proteins helping their activities.  See also [[Single stranded binding protein]].
 == 3D Structures of single-stranded DNA-binding protein ==
+[[Single-stranded DNA-binding protein 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-[[1gpc]] – SSB gp32 – Enterobacteria phage T4 <br />
-[[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br />
-[[1je5]] – SSB – Enterobacteria phage T7 <br />
-[[1adu]], [[1adv]], [[1anv]] – SSB C terminal – human adenovirus 5 <br />
-[[1urj]] – SSB – human herpesvirus 1 <br />
-[[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br />
-[[3ull]], [[1s3o]], [[2dud]] – hSSB residues 16-148 – human <br />
-[[1fgu]] – hSSB central domain<br />
-[[2b29]] – hSSB N terminal domain<br />
-[[4ipc]], [[4ipd]], [[4ipg]] – hSSB N terminal domain (mutant)<br />
-[[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br />
-[[1qvc]], [[1sru]] – EcSSB  <br />
-[[1o7i]] – SSB residues 1-119 – ''Sulfolobus solfataricus''<br />
-[[1ue1]], [[1ue5]], [[1ue7]], [[1ue6]] – SSB – ''Mycobacterium tuberculosis'' <br />
-[[1x3e]], [[1x3f]], [[1x3g]] – MsSSB – ''Mycobacterium smegmatis'' <br />
-[[1se8]] – DrSSB – ''Deinococcus radiodurans'' <br />
-[[4exw]] – SSB DdrB – ''Deinococcus geothermalis'' <br />
-[[1z9f]] – SSB – ''Thermotoga maritima'' <br />
-[[2cwa]] – SSB – ''Thermus thermophilus'' <br />
-[[2fxq]], [[2ihe]] – TaSSB – ''Thermus aquaticus'' <br />
-[[2ihf]] – TaSSB (mutant) <br />
-[[2hql]] – SSB – ''Mycoplasma pneumoniae'' <br />
-[[3eiv]] – ScSSB – ''Streptomyces coelicolor''<br />
-[[4dam]] – ScSSB (mutant) <br />
-[[3lgj]], [[3pgz]] – SSB – ''Bartonella henselae'' <br />
-[[3afp]], [[3afq]] – SSB – ''Mycobacterium leprae'' <br />
-[[3tqy]] – SSB – ''Coxiella burnetii'' <br />
-[[3tek]] – SSB N terminal – ''Thermoproteus tenax''<br />
-[[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br />
-[[3dm3]] – SSB A domain – ''Methancaldococcus jannaschii''<br />
-===SSB complex with ssDNA===
-[[1eyg]] – EcSSB chymotryptic domain + ssDNA <br />
-[[1eqq]] – EcSSB + ssDNA <br />
-[[2vw9]] – HpSSB + ssDNA <br />
-[[3vdy]] – SSB + ssDNA – ''Bacillus subtilis''<br />
-[[3a5u]] – MsSSB chymotryptic domain + ssDNA <br />
-[[3udg]] – DrSSB + ssDNA <br />
-===SSB other complexes===
-[[3ufm]], [[3uf7]] – DrSSB C terminal + uracil-DNA glycosylase <br />
-[[2b3g]] – hSSB N terminal domain + tumor suppressor P53<br />
-[[4nb3]] – hSSB N terminal domain (mutant) + polypeptide<br />
-[[4ijh]], [[4ijl]], [[4iph]], [[4luo]], [[4luv]], [[4luz]], [[4lw1]], [[4lwc]], [[4o0a]] – hSSB N terminal domain (mutant) + inhibitor<br />
+== References ==
+<references/>
 [[Category:Topic Page]]