Single-stranded DNA-binding protein

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Current revision

References

↑ Marceau AH. Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repair. Methods Mol Biol. 2012;922:1-21. doi: 10.1007/978-1-62703-032-8_1. PMID:22976174 doi:http://dx.doi.org/10.1007/978-1-62703-032-8_1
↑ Ishibashi T, Kimura S, Furukawa T, Hatanaka M, Hashimoto J, Sakaguchi K. Two types of replication protein A 70 kDa subunit in rice, Oryza sativa: molecular cloning, characterization, and cellular & tissue distribution. Gene. 2001 Jul 11;272(1-2):335-43. PMID:11470540 doi:10.1016/s0378-1119(01)00555-8

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Michal Harel, Alexander Berchansky

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 *  '''Viral SSB proteins''' are monomeric.<br />
 *    '''Eukaryotic SSB''' ('''Replication protein A''' – RPA) is a heterotrimer composed of RPA70, RPA32 and RPA14.  RPA has 6 DNA-binding domains (DBD).<br />
+*'''Replication protein A70''' is the eukaryotic SSB 70kDa subunit<ref>PMID:11470540</ref>.
 *   '''Mitochondrial human SSB (HsmtSSB)''' is a homotetramer.
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 </StructureSection>
-== 3D Structures of single-stranded DNA-binding protein ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Single-stranded DNA-binding protein
-**[[3ull]], [[1s3o]], [[2dud]] – HsmtSSB residues 16-148 – human <br />
-**[[5d8e]], [[5d8f]] – hSSB residues 1-109 (mutant) <br />
-**[[6iwv]] – hSSB 2 residues 10-77 <br />
-**[[6s9r]] – SSB – ''Drosophila melanogaster'' <br />
-**[[6cqk]], [[6cqm]], [[6cqo]] – ySSB N terminal domain - yeast<br />
-**[[5m1x]] – ySSB N-OB domain (mutant)<br />
-**[[1gpc]] – SSB gp32 – Enterobacteria phage T4 <br />
-**[[2a1k]] – SSB gp32 – Enterobacteria phage RB69 <br />
-**[[1je5]] – SSB – Enterobacteria phage T7 <br />
-**[[5odk]], [[5odj]] – Enc34SSB – Enterobacteria phage Enc34 <br />
-**[[1vqe]], [[1yha]], [[1vqb]] – F1SSB – Enterobacteria phage F1<br />
-**[[1vqa]], [[1vqc]], [[1vqd]], [[1vqe]], [[1vqf]], [[1vqg]], [[1vqh]], [[1vqi]], [[1vqj]], [[1ae2]], [[1ae3]], [[1gkh]] – F1SSB (mutant) <br />
-**[[2gn5]] – M13SSB – Enterobacteria phage M13<br />
-**[[2gva]], [[2gvb]] – M13SSB (mutant) - NMR<br />
-**[[1adu]], [[1adv]], [[1anv]], [[2waz]], [[2wb0]] – SSB C terminal – human adenovirus 5 <br />
-**[[1urj]] – SSB – human herpesvirus 1 <br />
-**[[1pfs]] – SSB (mutant) – Pseudomonas phage PF3 - NMR<br />
-**[[1kaw]] – EcSSB chymotryptic domain – ''Escherichia coli'' <br />
-**[[1qvc]], [[1sru]] – EcSSB  <br />
-**[[1o7i]] – SsSSB residues 1-119 – ''Sulfolobus solfataricus''<br />
-**[[1ue1]], [[1ue5]], [[1ue7]], [[1ue6]] – SSB – ''Mycobacterium tuberculosis'' <br />
-**[[1x3e]], [[1x3f]], [[1x3g]], [[5gqo]] – MsSSB – ''Mycobacterium smegmatis'' <br />
-**[[1se8]] – DrSSB – ''Deinococcus radiodurans'' <br />
-**[[4exw]] – SSB DdrB – ''Deinococcus geothermalis'' <br />
-**[[1z9f]] – SSB – ''Thermotoga maritima'' <br />
-**[[2cwa]] – SSB – ''Thermus thermophilus'' <br />
-**[[2fxq]], [[2ihe]] – TaSSB – ''Thermus aquaticus'' <br />
-**[[2ihf]] – TaSSB (mutant) <br />
-**[[2hql]] – SSB – ''Mycoplasma pneumoniae'' <br />
-**[[3eiv]] – ScSSB – ''Streptomyces coelicolor''<br />
-**[[4dam]] – ScSSB (mutant) <br />
-**[[3lgj]], [[3pgz]] – SSB – ''Bartonella henselae'' <br />
-**[[3afp]], [[3afq]] – SSB – ''Mycobacterium leprae'' <br />
-**[[3tqy]] – SSB – ''Coxiella burnetii'' <br />
-**[[3tek]] – SSB N terminal – ''Thermoproteus tenax''<br />
-**[[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br />
-**[[3dm3]] – SSB A domain – ''Methancaldococcus jannaschii''<br />
-**[[5xgt]], [[5yyu]] – SSB N-terminal – ''Staphylococcus aureus''<br />
-**[[6bhw]] – BsSSB – ''Bacillus subtilis''<br />
-**[[5yuo]] – PaSSB – ''Pseudomonas aeruginosa''<br />
-*Single-stranded DNA-binding protein complex with ssDNA
-**[[1eyg]] – EcSSB chymotryptic domain + ssDNA <br />
-**[[1eqq]] – EcSSB + ssDNA <br />
-**[[2vw9]] – HpSSB + ssDNA <br />
-**[[3vdy]], [[6bhx]] – BsSSB + ssDNA <br />
-**[[3a5u]] – MsSSB chymotryptic domain + ssDNA <br />
-**[[3udg]] – DrSSB + ssDNA <br />
-**[[2mna]] – SsSSB + ssDNA - NMR<br />
-**[[6jdg]], [[6irq]] – PaSSB + ssDNA  <br />
-**[[5odn]] – SrSSB + ssDNA - ''Salinibacter ruber'' <br />
-**[[5odp]] – SrSSB (mutant) + ssDNA <br />
-**[[5odl]] – Enc34SSB + ssDNA <br />
-*Other single-stranded DNA-binding protein complexes
-**[[6rup]] – hSSB residues 16-148 + peptide<br />
-**[[6tyd]] – hSSB 2 residues 1-94 + LDB1 <br />
-**[[3ufm]], [[3uf7]] – DrSSB C terminal + uracil-DNA glycosylase <br />
-**[[5yun]] – PaSSB + myricetin <br />
-*Replication protein A70
-**[[1l1o]] – hRPA14 + hRPA32 central domain + hRPA70 C terminal <br />
-**[[1ewi]], [[2b29]] - hRPA70 N terminal - NMR<br />
-**[[4ipc]], [[4ipd]], [[4ipg]] - hRPA70 N terminal (mutant) <br />
-**[[1fgu]] – hRPA70 central domain  <br />
-**[[1jmc]] – hRPA70 central domain + DNA <br />
-**[[2b3g]] - hRPA70 N terminal + p53 peptide<br />
-**[[5eay]] - hRPA70 N terminal + DNA2 peptide<br />
-**[[4nb3]], [[5n85]] - hRPA70 N terminal (mutant) + peptide<br />
-**[[5n8a]] - hRPA70 N terminal (mutant) + PrimPol<br />
-**[[4ijh]], [[4ijl]], [[4iph]], [[4luo]], [[4luv]], [[4luz]], [[4lw1]], [[4lwc]], [[4o0a]], [[4r4c]], [[4r4i]], [[4r4o]], [[4r4q]], [[4r4t]], [[5e7n]] - hRPA70 N terminal (mutant) + inhibitor<br />
-**[[1ynx]] – yRPA69 DBD-A – NMR<br />
-**[[6i52]] – yRPA1 + yRPA2 + yRPA3 + ssDNA – Cryo EM <br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]