Sodium-hydrogen exchange regulatory factor

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Sodium-hydrogen exchange regulatory factors''' (NHERF) are multif...)
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<StructureSection load='4q3h' size='340' side='right' caption='Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod [[4q3h]])' scene=''>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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'''Sodium-hydrogen exchange regulatory factors''' (NHERF) are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>.
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'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>.
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* '''NHERF-1''' is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>. It transduces cyclic AMP signals that inhibit the sodium-hydrogen exchanger present at the surface of kidney and gut<ref>PMID:12586353</ref>. NHERF-1 contains 2 PDZ domains and one erm domain.
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== Disease ==
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* '''NHERF-2''' is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling<ref>PMID:22343917</ref>. NHERF-2 contains 2 PDZ domains and one erm domain.
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*'''NHERF-3''' contains 4 PDZ domains no erm domain<ref>PMID:15905209</ref>.
== Relevance ==
== Relevance ==
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NHERF-1 inhibitors represent a potentially effective therapeutic approach to the treatment of hear failure<ref>PMID:12223070</ref>. NHERF-1 has a vital role in kidney cell survival<ref>PMID:25680790</ref>. NHERF are known to be involved in pathophysiologies of many brain diseases like epilepsy, Alzhheimer's disease, neuropathic pain and stroke.
== Structural highlights ==
== Structural highlights ==
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NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal.
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NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft<ref>PMID:26010555</ref>.
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</StructureSection>
 
== 3D Structures of sodium-hydrogen exchange regulatory factor ==
== 3D Structures of sodium-hydrogen exchange regulatory factor ==
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[[Sodium-hydrogen exchange regulatory factor 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Sodium-hydrogen exchange regulatory factor 1
 
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**[[4jl7]], [[4lmm]], [[4mpa]], [[4n6x]], [[4pqw]], [[1i92]], [[1g9o]], [[1gq5]] – hNHERF-1 PDZ 1 domain – human <br />
 
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**[[2m0t]] – hNHERF-1 PDZ 1 domain - NMR <br />
 
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**[[2m0u]] – hNHERF-1 PDZ 1 domain + CFTR C-terminal peptide - NMR <br />
 
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**[[2ozf]], [[4q3h]] – hNHERF-1 PDZ 2 domain <br />
 
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**[[2jxo]], [[2kjd]] – hNHERF-1 PDZ 2 domain - NMR <br />
 
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**[[2m0w]] – hNHERF-1 PDZ 2 domain + CFTR C-terminal peptide - NMR <br />
 
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**[[2krg]] – hNHERF-1 residues 150-358 - NMR <br />
 
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*Sodium-hydrogen exchange regulatory factor 2
 
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**[[2ocs]] – hNHERF-2 PDZ 1 domain <br />
 
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**[[2he4]] – hNHERF-2 PDZ 2 domain (mutant)<br />
 
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*Sodium-hydrogen exchange regulatory factor 3
 
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**[[3ngh]] – mNHERF-3 PDZ 1 domain - mouse<br />
 
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**[[4f8k]] – mNHERF-3 PDZ 1 domain (mutant)<br />
 
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**[[4q2p]] – hNHERF-3 PDZ 2 domain <br />
 
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**[[3r68]], [[3r69]] – mNHERF-3 PDZ 3 domain<br />
 
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**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
 
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**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod 4q3h)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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