Spindlin
From Proteopedia
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| - | <StructureSection load='4mzg' size=' | + | <StructureSection load='4mzg' size='350' side='right' caption='Human spindlin-1 (skyblue) complex with histone H3 peptide (wheat) containing trimethyl lysine, MPD, Mg+2 (green) and Cl- (green) ions (PDB code [[4mzg]])' scene='77/778344/Cv/1'> |
| - | + | __TOC__ | |
== Function == | == Function == | ||
| - | '''Spindlin-1''' (SPIN1) is a Tudor-like domain-containing protein is a histone methylation effector protein and facilitates the expression of rRNA genes<ref>PMID:21960006</ref>. SPIN1 senses a cis-tail histone H3 methylation pattern. '''Spindlin-2B''' is involved in the regulation of cell cycle progression. | + | '''Spindlin-1''' (SPIN1) is a Tudor-like domain-containing protein which is a histone methylation effector protein and facilitates the expression of rRNA genes<ref>PMID:21960006</ref>. SPIN1 senses a cis-tail histone H3 methylation pattern. |
| + | *'''Spindlin-2B''' is involved in the regulation of cell cycle progression. | ||
| + | *'''Spindlin-4''' binds trimethylated histone H3K4<ref>PMID:33636084</ref>. | ||
== Relevance == | == Relevance == | ||
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== Structural highlights == | == Structural highlights == | ||
| - | The crystal complex of SPIN1 and histone H3 peptide shows the encapsulation of the histone trimethyllysine and its Arg in hydrophobic pockets of SPIN1<ref>PMID:24589551</ref>. | + | The crystal complex of SPIN1 and histone H3 peptide shows the <scene name='77/778344/Cv/4'>encapsulation of the histone trimethyllysine</scene> and <scene name='77/778344/Cv/5'>its Arg</scene> in hydrophobic pockets of SPIN1<ref>PMID:24589551</ref>. |
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== 3D Structures of spindlin == | == 3D Structures of spindlin == | ||
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**[[2ns2]] – hSPIN1 – human <br /> | **[[2ns2]] – hSPIN1 – human <br /> | ||
| - | **[[4mzg]], [[4mzh]], [[4mzf]], [[4h75]], [[5y5w]] – hSPIN1 + histone peptide <br /> | + | **[[4mzg]], [[4mzh]], [[4mzf]], [[4h75]], [[5y5w]], [[7bqz]], [[7bu9]] – hSPIN1 + histone peptide <br /> |
| - | **[[ | + | **[[5jsg]], [[5jsj]], [[6i8b]], [[6i8l]], [[6i8y]], [[6qpl]], [[7ocb]] – hSPIN1 + inhibitor <br /> |
| + | **[[7e9m]], [[7ea1]] – hSPIN1 + SPIN-DOC <br /> | ||
| + | **[[7cna]] – hSPIN1 + SPIN-DOC + inhibitor <br /> | ||
| + | **[[8gtx]] – hSPIN1 + HBx <br /> | ||
*Spindlin-2B | *Spindlin-2B | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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