Syntaxin

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Syntaxin''' (Stx) are membrane-integrated proteins that are instru...)
Current revision (07:04, 18 August 2024) (edit) (undo)
 
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<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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__TOC__
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== Function ==
== Function ==
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'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vescicles. Sts-1 is essential in the fusion machinery in the brain. It forms a 4-helical bundle comples with proteins SNAP-25 and VAMP2d which drives fusion of vescicles with the plasma membrane<ref>PMID:26903802</ref>.
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'''Syntaxin''' (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles.
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*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>.
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== Disease ==
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*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>.
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*'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events.
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*'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>.
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*'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>.
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*'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>.
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*'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>.
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*'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>.
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*'''Stx-VAM3P''' is involved invacuolar assembly<ref>PMID:9202390</ref>.
== Relevance ==
== Relevance ==
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The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor<ref>PMID:26903802</ref>.
== Structural highlights ==
== Structural highlights ==
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<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).
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</StructureSection>
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==3D structures of syntaxin==
==3D structures of syntaxin==
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[[Syntaxin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Syntaxin 1
 
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**[[2xhe]] – Stx1 + Unc18 – Monosiga brevicollis<br />
 
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*Syntaxin 1A
 
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**[[1ez3]] – rStx1a N-terminal – rat<br />
 
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**[[1br0]] – rStx1a N-terminal (mutant) – NMR<br />
 
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**[[1hvv]] – rStx1a SNARE motif<br />
 
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**[[2m8r]] – rStx1a SNARE motif - NMR<br />
 
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**[[1jth]] – rStx1a SNARE motif + SNAP25<br />
 
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**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
 
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**[[1n7s]], [[3h7d]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
 
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**[[3rk3]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
 
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**[[5ccg]], [[5cch]], [[5cci]], [[5kj7]], [[5kj8]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
 
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**[[2n1t]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 - NMR<br />
 
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**[[3c98]], [[4jeh]], [[4jeu]] – rStx1a + Unc18 <br />
 
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*Syntaxin 6
 
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**[[1lvf]] – rStx6 N-terminal <br />
 
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**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
 
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*Syntaxin 7
 
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**[[1gl2]] – mStx7 core fragment + VAMP8 + rStx8 core fragment + VTI1-RP2 - mouse <br />
 
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*Syntaxin 10
 
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**[[4dnd]] – hStx10 <br />
 
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*Syntaxin 12
 
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**[[2dnx]] – hStx12 N-terminal - NMR<br />
 
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*Syntaxin 13
 
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**[[2nps]] – rStx13 SNARE motif + VAMP2 + hStx6 SNARE motif + VTI1-RP2 <br />
 
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*Syntaxin 17
 
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**[[4wy4]] – rStx17 SNARE motif + SNAP25 + VAMP2<br />
 
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*s-syntaxin
 
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**[[1s94]] – LpStx Habc domain – Loligo pealei<br />
 
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**[[1l4a]] – LpStx1a SNARE motif + SNAP25 + synaptobrevin + synaphin A<br />
 
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*Syntaxin VAM3
 
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**[[1hs7]] – Stx N-terminal – yeast - NMR<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd)

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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