Syntaxin
From Proteopedia
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<StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'> | <StructureSection load='3ipd' size='450' side='right' caption='Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code [[3ipd]])' scene='80/801795/Cv/5'> | ||
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== Function == | == Function == | ||
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*'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>. | *'''Stx-1''' is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane<ref>PMID:26903802</ref>. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs<ref>PMID:24218570</ref>. | ||
*'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>. | *'''Stx-1A''' regulates the function of transmembrane proteins like ion channels and neurotransmitter transporters<ref>PMID:18617632</ref>. | ||
| + | *'''Stx-6''' is a SNARE protein involved in a variety of internal membrane fusion events. | ||
| + | *'''Stx-7''' is involved in endosomal membrane fusion<ref>PMID:34408265</ref>. | ||
| + | *'''Stx-10''' is a SNARE protein localised to the trans-Golgi network<ref>PMID:16154903</ref>. | ||
| + | *'''Stx-12''' is a SNARE protein localised to the endosome<ref>PMID:9507000</ref>. | ||
| + | *'''Stx-13''' has a role in membrane expansion during neuronal development <ref>PMID:10886332</ref>. | ||
| + | *'''Stx-17''' is required for autophagosome-lysosome fusion<ref>PMID:23466629</ref>. | ||
| + | *'''Stx-VAM3P''' is involved invacuolar assembly<ref>PMID:9202390</ref>. | ||
== Relevance == | == Relevance == | ||
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==3D structures of syntaxin== | ==3D structures of syntaxin== | ||
[[Syntaxin 3D structures]] | [[Syntaxin 3D structures]] | ||
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| - | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| - | + | </StructureSection> | |
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
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