Thiamin phosphate synthase

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-...)
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<StructureSection load='2tps' size='400' side='right' caption='Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code [[2tps]])' scene='80/801260/Cv/1'>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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__TOC__
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== Function ==
== Function ==
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'''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>
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'''Thiamin phosphate synthase''' (TPS) or '''thiamin-phosphate pyrophosphorylase''' catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>.
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== Disease ==
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== Relevance ==
== Relevance ==
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Thiamin is an essential component of human diet. Thiamin deficiency is associated with neurodegenerative diseases<ref>PMID:19087359</ref>, delirium<ref>PMID:23696956</ref>, obesity<ref>PMID:25770253</ref> and results in beriberi<ref>PMID:25781926</ref> and in the alcoholic brain disease Korsakoff's syndrome<ref>PMID:10487391</ref>. TPS is involved in thiamin biosynthesis.
== Structural highlights ==
== Structural highlights ==
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</StructureSection>
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The <scene name='80/801260/Cv/11'>active site pocket of TPS is formed by three loop regions</scene>. TPS reaction products thiamin phosphate and pyrophosphate interact with various residues of the protein as well as with each other<ref>PMID:10350464</ref>.
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*<scene name='80/801260/Cv/12'>Active site pocket</scene>.
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*<scene name='80/801260/Cv/13'>Mg coordination site</scene>. Water molecules are shown as red spheres.
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*<scene name='80/801260/Cv/14'>Pyrophosphate binding site</scene>.
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*<scene name='80/801260/Cv/15'>Thiamin phosphate binding site</scene>.
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*<scene name='80/801260/Cv/16'>Whole active site</scene>.
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[[1g4e]], [[3o16]] - BsTPS (mutant) - Bacillus subtilis<br />
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==3D structures of thiamin phosphate synthase==
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[[1g4p]] - BsTPS (mutant) + pyrimidine derivative<br />
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[[1g67]], [[1g69]], [[1g6c]] - BsTPS (mutant) + pyrimidine derivative + PPi<br />
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1g4e]], [[3o16]] - BsTPS (mutant) - ''Bacillus subtilis''<br />
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[[1g4p]] - BsTPS (mutant) + Thz-P<br />
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[[1g67]], [[1g69]], [[1g6c]] - BsTPS (mutant) + Thz-P + PPi<br />
[[1g4t]] - BsTPS + thiamine phosphate derivative<br />
[[1g4t]] - BsTPS + thiamine phosphate derivative<br />
[[1g4s]] - BsTPS (mutant) + thiamine phosphate derivative<br />
[[1g4s]] - BsTPS (mutant) + thiamine phosphate derivative<br />
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[[2tps]] - BsTPS + thiamine phosphate derivative + PPi<br />
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[[2tps]] - BsTPS + thiamine phosphate + PPi<br />
[[3o15]] - BsTPS + thiazole phosphate derivative + PPi<br />
[[3o15]] - BsTPS + thiazole phosphate derivative + PPi<br />
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[[3o63]] - TPS + Pi - Mycobacterium tuberculosis<br />
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[[3o63]] - TPS + Pi - ''Mycobacterium tuberculosis''<br />
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[[1xi3]] - TPS - Pyrococcus furiosus<br />
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[[1xi3]] - TPS - ''Pyrococcus furiosus''<br />
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[[3ceu]] - TPS - ''Bacterioides thetaiotamicron''<br />
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
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[[Category:Topic Page]]

Current revision

Thiamin phosphate synthase complex with reaction products thiamin phosphate, pyrophosphate and Mg+2 ion (green) (PDB code 2tps)

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Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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